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Infectious Disease: Zika Virus
Therapy: Stem Cell Therapy
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Total 90 results found since Jan 2013.
Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment
Int J Mol Sci. 2023 Aug 31;24(17):13550. doi: 10.3390/ijms241713550.ABSTRACTNeural stem cells (NSCs) were described for the first time more than two decades ago for their ability to differentiate into all neural cell lineages. The isolation of NSCs from adults and embryos was carried out by various laboratories and in different species, from mice to humans. Similarly, no more than two decades ago, cancer stem cells were described. Cancer stem cells, previously identified in hematological malignancies, have now been isolated from several solid tumors (breast, brain, and gastrointestinal compartment). Though the origin of th...
Source: Molecular Medicine - September 9, 2023 Category: Molecular Biology Authors: Rosaria Tinnirello Cinzia Maria Chinnici Vitale Miceli Rosalia Bus à Matteo Bulati Alessia Gallo Giovanni Zito Pier Giulio Conaldi Gioacchin Iannolo Source Type: research
Inhibiting immunoregulatory amidase NAAA blocks ZIKV maturation in Human Neural Stem Cells
Antiviral Res. 2023 Jul 4:105664. doi: 10.1016/j.antiviral.2023.105664. Online ahead of print.ABSTRACTRecent evidence suggests that lipids play a crucial role in viral infections beyond their traditional functions of supplying envelope and energy, and creating protected niches for viral replication. In the case of Zika virus (ZIKV), it alters host lipids by enhancing lipogenesis and suppressing β-oxidation to generate viral factories at the endoplasmic reticulum (ER) interface. This discovery prompted us to hypothesize that interference with lipogenesis could serve as a dual antiviral and anti-inflammatory strategy to com...
Source: Antiviral Research - July 6, 2023 Category: Virology Authors: Michele Lai Veronica La Rocca Elena Iacono Carolina Filipponi Alessandro De Carli Domenico Favaro Rossella Fonnesu Fabio Filippini Pietro Giorgio Spezia Rachele Amato Elisa Catelli Baggiani Matteo Giulia Lottini Marco Onorati Nicola Clementi Giulia Freer Source Type: research
Human brain microphysiological systems in the study of neuroinfectious disorders
Exp Neurol. 2023 Apr 13:114409. doi: 10.1016/j.expneurol.2023.114409. Online ahead of print.ABSTRACTMicrophysiological systems (MPS) are 2D or 3D multicellular constructs able to mimic tissue microenvironments. The latest models encompass a range of techniques, including co-culturing of various cell types, utilization of scaffolds and extracellular matrix materials, perfusion systems, 3D culture methods, 3D bioprinting, organ-on-a-chip technology, and examination of tissue structures. Several human brain 3D cultures or brain MPS (BMPS) have emerged in the last decade. These organoids or spheroids are 3D culture systems der...
Source: Experimental Neurology - April 15, 2023 Category: Neurology Authors: Paula Barreras David Pamies Thomas Hartung Carlos A Pardo Source Type: research
Endemic or regionally limited bacterial and viral infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review
Lancet Haematol. 2023 Apr;10(4):e284-e294. doi: 10.1016/S2352-3026(23)00032-7.ABSTRACTLiterature discussing endemic and regionally limited infections in recipients of haematopoietic stem-cell transplantation (HSCT) outside western Europe and North America is scarce. This Worldwide Network for Blood and Marrow Transplantation (WBMT) article is part one of two papers aiming to provide guidance to transplantation centres around the globe regarding infection prevention and treatment, and considerations for transplantation based on current evidence and expert opinion. These recommendations were initially formulated by a core wr...
Source: Cancer Control - March 29, 2023 Category: Cancer & Oncology Authors: Ibrahim N Muhsen Sebastian Galeano Dietger Niederwieser Mickey B C Koh Per Ljungman Clarisse M Machado Mohamed A Kharfan-Dabaja Rafael de la Camara Yoshihisa Kodera Jeff Szer Walid Rasheed Simone Cesaro Shahrukh K Hashmi Adriana Seber Yoshiko Atsuta Mosta Source Type: research
Human microglial models to study host-virus interactions
Exp Neurol. 2023 Mar 10:114375. doi: 10.1016/j.expneurol.2023.114375. Online ahead of print.ABSTRACTMicroglia, the resident macrophage of the central nervous system, are increasingly recognized as contributing to diverse aspects of human development, health, and disease. In recent years, numerous studies in both mouse and human models have identified microglia as a "double edged sword" in the progression of neurotropic viral infections: protecting against viral replication and cell death in some contexts, while acting as viral reservoirs and promoting excess cellular stress and cytotoxicity in others. It is imperative to u...
Source: Herpes - March 12, 2023 Category: Infectious Diseases Authors: Rachel McMillan Ellen Wang Aaron Carlin Nicole G Coufal Source Type: research
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain
Cell Stem Cell. 2023 Mar 2;30(3):239-241. doi: 10.1016/j.stem.2023.02.002.ABSTRACTIn this issue, Wells et al. combine genetic multiplexing ("village-in-a-dish") and Stem-cell-derived NGN2-accelerated Progenitors (SNaPs) to evaluate genotype-phenotype relationships across 100 donors in the context of Zika virus infection in the developing brain. This resource will be broadly applicable in uncovering how genetic variation underlies risk for neurodevelopmental disorders.PMID:36868190 | DOI:10.1016/j.stem.2023.02.002
Source: Cell Stem Cell - March 3, 2023 Category: Stem Cells Authors: Carina Seah Kristen J Brennand Source Type: research
