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Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Plasma proteomics show altered inflammatory and mitochondrial proteins in patients with neurologic symptoms of post-acute sequelae of SARS-CoV-2 infection
Brain Behav Immun. 2023 Sep 11:S0889-1591(23)00253-2. doi: 10.1016/j.bbi.2023.08.022. Online ahead of print.ABSTRACTPersistent symptoms of COVID-19 survivors constitute long COVID syndrome, also called post-acute sequelae of SARS-CoV-2 infection (PASC). Neurologic manifestations of PASC (Neuro-PASC) are particularly debilitating, long lasting, and poorly understood. To gain insight into the pathogenesis of PASC, we leveraged a well-characterized group of Neuro-PASC (NP) patients seen at our Neuro-COVID-19 clinic who had mild acute COVID-19 and never required hospitalization, to investigate their plasma proteome. Using the ...
Source: Brain, Behavior, and Immunity - September 13, 2023 Category: Neurology Authors: Barbara A Hanson Lavanya Visvabharathy Zachary S Orban Millenia Jimenez Ayush Batra Eric M Liotta Robert K DeLisle Jeffrey D Klausner Pinchas Cohen Advait S Padhye George Tachas Igor J Koralnik Source Type: research

Mast cell-mediated immune regulation in health and disease
Front Med (Lausanne). 2023 Aug 17;10:1213320. doi: 10.3389/fmed.2023.1213320. eCollection 2023.ABSTRACTMast cells are important components of the immune system, and they perform pro-inflammatory as well as anti-inflammatory roles in the complex process of immune regulation in health and disease. Because of their strategic perivascular localization, sensitivity and adaptability to the microenvironment, and ability to release a variety of preformed and newly synthesized effector molecules, mast cells perform unique functions in almost all organs. Additionally, Mast cells express a wide range of surface and cytoplasmic recept...
Source: Atherosclerosis - September 4, 2023 Category: Cardiology Authors: Kottarappat N Dileepan Vineesh V Raveendran Rishi Sharma Harita Abraham Rajat Barua Vikas Singh Ram Sharma Mukut Sharma Source Type: research

Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer
CONCLUSION: This study elucidated the functional mechanisms of LAYN from a pan-cancer perspective and provided novel insights into cancer prognosis, metastasis, and immunotherapy. LAYN has the potential to become a new target of mRNA vaccines and molecular therapies in tumors.PMID:37335337 | DOI:10.1007/s00432-023-04986-7
Source: Cell Research - June 19, 2023 Category: Cytology Authors: Wang Jiawen Wang Jinfu Liu Jianyong Zhang Yaoguang Wang Jianye Source Type: research

Lung Pericytes as Mediators of Inflammation
Am J Physiol Lung Cell Mol Physiol. 2023 May 2. doi: 10.1152/ajplung.00354.2022. Online ahead of print.ABSTRACTPericytes are microvascular mural cells that directly contact endothelial cells. They have long been recognized for their roles in vascular development and homeostasis, but more recently have been identified as key mediators of the host response to injury. In this context, pericytes possess a surprising degree of cellular plasticity, behaving dynamically when activated and potentially participating in a range of divergent host responses to injury. While there has been much interest in the role of pericytes in fibr...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - May 2, 2023 Category: Cytology Authors: Samuel G Rayner Chi F Hung W Conrad Liles William A Altemeier Source Type: research

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