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Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
Antiviral Res. 2023 Sep 8:105716. doi: 10.1016/j.antiviral.2023.105716. Online ahead of print.ABSTRACTSangivamycin (S) is an adenosine (A) nucleoside analog with low nanomolar antiviral activity against SARS-CoV-2 in vitro. Previously, low nanomolar antiviral efficacy was revealed when tested against multiple viral variants in several cell types. SARS-CoV-2 RNA isolated from live virus infected cells and the virions released from these cells was analyzed by mass spectrometry (MS) for S incorporation. Dose-dependent incorporation occurred up to 1.8 S per 1,000 nucleotides (49 S per genome) throughout the viral genomes isola...
Source: Antiviral Research - September 10, 2023 Category: Virology Authors: Ryan P Bennett Yasemin Yolu ç Jason D Salter Alexander Ripp Henning J Jessen Stefanie M Kaiser Harold C Smith Source Type: research
An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1 & amp;2 and its' most variants
This study provides an effective weapon combating SARS-CoV-2, proposes a new strategy overcoming the virus escape, and lays strategic reserves for rapid response to potential future outbreaks of "SARS-CoV-3".PMID:37690653 | DOI:10.1016/j.ijbiomac.2023.126817
Source: International Journal of Biological Macromolecules - September 10, 2023 Category: Biochemistry Authors: Weihong Zeng Xiaoying Jia Xiangyang Chi Xinghai Zhang Entao Li Yan Wu Yang Liu Jin Han Kang Ni Xiaodong Ye Xiaowen Hu Huan Ma Changming Yu Sandra Chiu Tengchuan Jin Source Type: research
Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
Antiviral Res. 2023 Sep 8:105716. doi: 10.1016/j.antiviral.2023.105716. Online ahead of print.ABSTRACTSangivamycin (S) is an adenosine (A) nucleoside analog with low nanomolar antiviral activity against SARS-CoV-2 in vitro. Previously, low nanomolar antiviral efficacy was revealed when tested against multiple viral variants in several cell types. SARS-CoV-2 RNA isolated from live virus infected cells and the virions released from these cells was analyzed by mass spectrometry (MS) for S incorporation. Dose-dependent incorporation occurred up to 1.8 S per 1,000 nucleotides (49 S per genome) throughout the viral genomes isola...
Source: Antiviral Research - September 10, 2023 Category: Virology Authors: Ryan P Bennett Yasemin Yolu ç Jason D Salter Alexander Ripp Henning J Jessen Stefanie M Kaiser Harold C Smith Source Type: research
Importance of screening severe COVID-19 patients for IFN- λ1, IL-6 and anti-S1 IgG levels
The objective of this study is to screen IFN-λ1, IL-6 and antibody levels in consecutive serum sample sets of COVID-19 patients. A total of 365 serum samples collected from 208 hospitalized COVID-19 patients were analyzed for IFN-λ1 and IL-6 levels as well as SARS-CoV-2 neutralizing antibodies and anti-S1 IgG antibodies. Analyses of serum samples for cytokine levels showed that IFN-λ1 (>8 pg/mL) and IL-6 (>2 pg/mL) were detected in approximately 64% and 21% patients, respectively. A decrement in IFN-λ1 levels and IL-6 levels above 35 pg/mL can be sign of clinical severity and upcoming dead. An increment in IL-6 l...
Source: Cytokine - September 10, 2023 Category: Molecular Biology Authors: Olcay Buse Kenano ğlu Ayt ül Gül H üseyin Can Muhammet Karakavuk Sedef Erkunt Alak G ülay Korukluoğlu Ay şe Başak Altaş H üsnü Pullukçu Aysu De ğirmenci Döşkaya Tu ğba Karakavuk Ceren G ül Candan Çiçek Mehmet Sezai Ta şbakan Ak ın Çi Source Type: research
Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2 Omicron BA.2 variant infection: a randomized controlled trial
CONCLUSION: PSNI can reduce the DVS of patients with mild and asymptomatic infection with SARS-CoV-2 Omicron BA.2 variant.PMID:37691090 | DOI:10.1007/s12519-023-00749-z
Source: World Journal of Pediatrics : WJP - September 10, 2023 Category: Pediatrics Authors: Ji-Lei Lin Fen Zhang Yan-Bo Li Shu-Hua Yuan Jin-Hong Wu Jing Zhang Lei Zhang Yi He Jie Chen Yong Yin Source Type: research
Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
Antiviral Res. 2023 Sep 8:105716. doi: 10.1016/j.antiviral.2023.105716. Online ahead of print.ABSTRACTSangivamycin (S) is an adenosine (A) nucleoside analog with low nanomolar antiviral activity against SARS-CoV-2 in vitro. Previously, low nanomolar antiviral efficacy was revealed when tested against multiple viral variants in several cell types. SARS-CoV-2 RNA isolated from live virus infected cells and the virions released from these cells was analyzed by mass spectrometry (MS) for S incorporation. Dose-dependent incorporation occurred up to 1.8 S per 1,000 nucleotides (49 S per genome) throughout the viral genomes isola...
Source: Antiviral Research - September 10, 2023 Category: Virology Authors: Ryan P Bennett Yasemin Yolu ç Jason D Salter Alexander Ripp Henning J Jessen Stefanie M Kaiser Harold C Smith Source Type: research
Importance of screening severe COVID-19 patients for IFN- λ1, IL-6 and anti-S1 IgG levels
The objective of this study is to screen IFN-λ1, IL-6 and antibody levels in consecutive serum sample sets of COVID-19 patients. A total of 365 serum samples collected from 208 hospitalized COVID-19 patients were analyzed for IFN-λ1 and IL-6 levels as well as SARS-CoV-2 neutralizing antibodies and anti-S1 IgG antibodies. Analyses of serum samples for cytokine levels showed that IFN-λ1 (>8 pg/mL) and IL-6 (>2 pg/mL) were detected in approximately 64% and 21% patients, respectively. A decrement in IFN-λ1 levels and IL-6 levels above 35 pg/mL can be sign of clinical severity and upcoming dead. An increment in IL-6 l...
Source: Cytokine - September 10, 2023 Category: Molecular Biology Authors: Olcay Buse Kenano ğlu Ayt ül Gül H üseyin Can Muhammet Karakavuk Sedef Erkunt Alak G ülay Korukluoğlu Ay şe Başak Altaş H üsnü Pullukçu Aysu De ğirmenci Döşkaya Tu ğba Karakavuk Ceren G ül Candan Çiçek Mehmet Sezai Ta şbakan Ak ın Çi Source Type: research
Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
Antiviral Res. 2023 Sep 8:105716. doi: 10.1016/j.antiviral.2023.105716. Online ahead of print.ABSTRACTSangivamycin (S) is an adenosine (A) nucleoside analog with low nanomolar antiviral activity against SARS-CoV-2 in vitro. Previously, low nanomolar antiviral efficacy was revealed when tested against multiple viral variants in several cell types. SARS-CoV-2 RNA isolated from live virus infected cells and the virions released from these cells was analyzed by mass spectrometry (MS) for S incorporation. Dose-dependent incorporation occurred up to 1.8 S per 1,000 nucleotides (49 S per genome) throughout the viral genomes isola...
Source: Antiviral Research - September 10, 2023 Category: Virology Authors: Ryan P Bennett Yasemin Yolu ç Jason D Salter Alexander Ripp Henning J Jessen Stefanie M Kaiser Harold C Smith Source Type: research
Importance of screening severe COVID-19 patients for IFN- λ1, IL-6 and anti-S1 IgG levels
The objective of this study is to screen IFN-λ1, IL-6 and antibody levels in consecutive serum sample sets of COVID-19 patients. A total of 365 serum samples collected from 208 hospitalized COVID-19 patients were analyzed for IFN-λ1 and IL-6 levels as well as SARS-CoV-2 neutralizing antibodies and anti-S1 IgG antibodies. Analyses of serum samples for cytokine levels showed that IFN-λ1 (>8 pg/mL) and IL-6 (>2 pg/mL) were detected in approximately 64% and 21% patients, respectively. A decrement in IFN-λ1 levels and IL-6 levels above 35 pg/mL can be sign of clinical severity and upcoming dead. An increment in IL-6 l...
Source: Cytokine - September 10, 2023 Category: Molecular Biology Authors: Olcay Buse Kenano ğlu Ayt ül Gül H üseyin Can Muhammet Karakavuk Sedef Erkunt Alak G ülay Korukluoğlu Ay şe Başak Altaş H üsnü Pullukçu Aysu De ğirmenci Döşkaya Tu ğba Karakavuk Ceren G ül Candan Çiçek Mehmet Sezai Ta şbakan Ak ın Çi Source Type: research
Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
Antiviral Res. 2023 Sep 9;218:105716. doi: 10.1016/j.antiviral.2023.105716. Online ahead of print.ABSTRACTSangivamycin (S) is an adenosine (A) nucleoside analog with low nanomolar antiviral activity against SARS-CoV-2 in vitro. Previously, low nanomolar antiviral efficacy was revealed when tested against multiple viral variants in several cell types. SARS-CoV-2 RNA isolated from live virus infected cells and the virions released from these cells was analyzed by mass spectrometry (MS) for S incorporation. Dose-dependent incorporation occurred up to 1.8 S per 1,000 nucleotides (49 S per genome) throughout the viral genomes i...
Source: Antiviral Research - September 10, 2023 Category: Virology Authors: Ryan P Bennett Yasemin Yolu ç Jason D Salter Alexander Ripp Henning J Jessen Stefanie M Kaiser Harold C Smith Source Type: research
Importance of screening severe COVID-19 patients for IFN- λ1, IL-6 and anti-S1 IgG levels
The objective of this study is to screen IFN-λ1, IL-6 and antibody levels in consecutive serum sample sets of COVID-19 patients. A total of 365 serum samples collected from 208 hospitalized COVID-19 patients were analyzed for IFN-λ1 and IL-6 levels as well as SARS-CoV-2 neutralizing antibodies and anti-S1 IgG antibodies. Analyses of serum samples for cytokine levels showed that IFN-λ1 (>8 pg/mL) and IL-6 (>2 pg/mL) were detected in approximately 64% and 21% patients, respectively. A decrement in IFN-λ1 levels and IL-6 levels above 35 pg/mL can be sign of clinical severity and upcoming dead. An increment in IL-6 l...
Source: Cytokine - September 10, 2023 Category: Molecular Biology Authors: Olcay Buse Kenano ğlu Ayt ül Gül H üseyin Can Muhammet Karakavuk Sedef Erkunt Alak G ülay Korukluoğlu Ay şe Başak Altaş H üsnü Pullukçu Aysu De ğirmenci Döşkaya Tu ğba Karakavuk Ceren G ül Candan Çiçek Mehmet Sezai Ta şbakan Ak ın Çi Source Type: research
Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2 Omicron BA.2 variant infection: a randomized controlled trial
CONCLUSION: PSNI can reduce the DVS of patients with mild and asymptomatic infection with SARS-CoV-2 Omicron BA.2 variant.PMID:37691090 | DOI:10.1007/s12519-023-00749-z
Source: World Journal of Pediatrics : WJP - September 10, 2023 Category: Pediatrics Authors: Ji-Lei Lin Fen Zhang Yan-Bo Li Shu-Hua Yuan Jin-Hong Wu Jing Zhang Lei Zhang Yi He Jie Chen Yong Yin Source Type: research
Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
Antiviral Res. 2023 Sep 8:105716. doi: 10.1016/j.antiviral.2023.105716. Online ahead of print.ABSTRACTSangivamycin (S) is an adenosine (A) nucleoside analog with low nanomolar antiviral activity against SARS-CoV-2 in vitro. Previously, low nanomolar antiviral efficacy was revealed when tested against multiple viral variants in several cell types. SARS-CoV-2 RNA isolated from live virus infected cells and the virions released from these cells was analyzed by mass spectrometry (MS) for S incorporation. Dose-dependent incorporation occurred up to 1.8 S per 1,000 nucleotides (49 S per genome) throughout the viral genomes isola...
Source: Antiviral Research - September 10, 2023 Category: Virology Authors: Ryan P Bennett Yasemin Yolu ç Jason D Salter Alexander Ripp Henning J Jessen Stefanie M Kaiser Harold C Smith Source Type: research
TWiV 1043: Marion Koopmans on COVID-19, Mpox, H5N1, polio and One Health
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics. Host: Vincent Racaniello Guest: Marion Koopmans Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) SARS-CoV-2 variants in Rotterdam wastewater (Sci Tot Envi...
Source: This Week in Virology - MP3 Edition - September 10, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
