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Infectious Disease: Bacterial Pneumonia
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A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with < b > < i > Streptococcus pneumoniae < /i > < /b >
Conclusions: In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome.Cerebrovasc Dis 2017;43:99-109
Source: Cerebrovascular Diseases - January 3, 2017 Category: Neurology Source Type: research
A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae
Conclusions: In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome.Cerebrovasc Dis 2017;43:99-109
Source: Cerebrovascular Diseases - January 4, 2017 Category: Neurology Source Type: research
Treatment with IgM-enriched intravenous immunoglobulins (IgM-IVIg) enhances clearance of stroke-associated bacterial lung infection
Immunology. 2022 Jul 26. doi: 10.1111/imm.13553. Online ahead of print.ABSTRACTPost-stroke infection is a common complication of stroke that is associated with poor outcome. We previously reported that stroke induces an ablation of multiple sub-populations of B cells and reduces levels of IgM antibody, which coincides with the development of spontaneous bacterial pneumonia. The loss of IgM after stroke could be an important determinant of infection susceptibility and highlights this pathway as a target for intervention. We treated mice with a replacement dose of IgM-enriched intravenous immunoglobulin (IgM-IVIg) prior to a...
Source: Immunology - July 26, 2022 Category: Allergy & Immunology Authors: Laura McCulloch Alison J Harris Alexandra Malbon Michael J D Daniels Mehwish Younas John R Grainger Stuart M Allan Craig J Smith Barry W McColl Source Type: research
Get the flu vaccine, reduce your risk of death
Last year was a lousy year for the flu vaccine. Hospitalizations for flu hit a nine-year high, and the vaccine prevented flu in only 23% of all recipients, compared with 50% to 60% of recipients in prior years.
Why does the flu vaccine work well in some winters and not others? The flu vaccine primes the immune system to attack two proteins on the surface of the influenza A virus, hemagglutinin (H) and neuraminidase (N). Different flu strains have different combinations of these proteins — for example, the strains targeted by recent flu vaccines are H3N2 and H1N1.
Unfortunately, the influenza virus is microbiology’s ans...
Source: New Harvard Health Information - September 15, 2015 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Cold and Flu Vaccines Flu Shot flu vaccine Source Type: news
Outcomes of extracorporeal membrane oxygenation in acute respiratory distress syndrome due to COVID ‐19: The lessons learned from the first wave of COVID‐19
ConclusionsBased on our experience, ECMO can improve refractory ARDS due to COVID ‐19 in select patients. Proper control of bacterial infections during COVID‐19 immunomodulation therapy may be critical to improving survival.
Source: Journal of Cardiac Surgery - March 19, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Cameron Blazoski,
Michael Baram,
Hitoshi Hirose Tags: ORIGINAL ARTICLE Source Type: research
Pneumonia: When Antibiotics Are Not the Answer
We present the case of an 88-year-old bedridden man, with hypertension, multiple myeloma, coronary artery disease, ischemic stroke, seizures, dysphagia, and constipation under treatment with mineral oil. He was brought to the emergency department after 3 days of cough, dysphagia, and dyspnea, following a recent hospitalization, due to a health care–associated pneumonia. A chest computed tomography scan obtained showed bilateral multifocal opacities with consolidates described as Hounsfield units of −62, consistent with fat. A diagnosis of lipoid pneumonia was done, and mineral oil was discontinued. Given the patient’...
Source: Infectious Diseases in Clinical Practice - October 31, 2014 Category: Infectious Diseases Tags: Case Reports Source Type: research
A True Hematologic Emergency
BY GREGORY TAYLOR, DO, & JACKLYN MCPARLANE, DOA 33-year-old woman with a past medical history of sickle cell SS presented to the emergency department with chest pain, difficulty breathing, and a cough for two days. Her chest pain was diffuse, without radiation, and partially reproducible. Her cough was nonproductive, and she also reported fever and chills.The patient noted this was different from her normal back and leg pain from past sickle cell crises. She was following up with a sickle cell specialist, and was compliant with her hydroxyurea treatment.Her temperature was 102.8°F, blood pressure was 94/60 mm...
Source: The Case Files - June 26, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Prevalence of COVID-19 Mimics in the Emergency Department
Conclusion Several potentially fatal diseases remain masked among the wave of COVID-19 mimics. It is imperative that a thorough differential diagnostic panel be considered prior to the rendering of a COVID-19 diagnosis.PMID:34334560 | DOI:10.2169/internalmedicine.6434-20
Source: Internal Medicine - August 2, 2021 Category: Internal Medicine Authors: Satoshi Kurihara Mikio Nakajima Richard H Kaszynski Yasuhiro Yamamoto Koichiro Santo Ryo Takane Hayato Tokuno Ayaka Ishihata Hitoshi Ando Maki Miwa Shoichiro Hamada Tomotsugu Nakano Masamitsu Shirokawa Hideaki Goto Yoshihiro Yamaguchi Source Type: research
