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Endovascular Thrombectomy in Acute Ischemic Stroke Advances in Interventional Cardiology
Despite several effective strategies of stroke prevention, the stroke epidemic still constitutes the leading cause of permanent disability. The recent series of well-designed, convincingly-positive randomized controlled trials of endovascular thrombectomy in stroke patients with large vessel occlusion launched a paradigm shift and a new era in acute stroke management. The present review provides an overview of the technical aspects of the procedure, discusses patient selection criteria, summarizes the current evidence from randomized trials about its efficacy and safety, and explores its implications in the organization of acute stroke care.
Source: Circulation: Cardiovascular Interventions - January 8, 2018 Category: Cardiology Authors: Papanagiotou, P., Ntaios, G. Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Advances in Interventional Cardiology Source Type: research

The Need to Evaluate Net Clinical Effect of Stroke Prevention Therapy in Patients with End Stage Renal Disease and Atrial Fibrillation.
Abstract Chronic kidney disease (CKD) and atrial fibrillation (AF) are both emerging health epidemics worldwide. Atrial fibrillation is the most common heart rhythm disorder and the burden of this dysrhythmia is expected to increase as the population ages(1). Similarly, chronic kidney disease is a disease of the elderly that is estimated to affect 40-50% of US adults over 65 in the near future(2,3). This is likely due to manifestations of common risk factors and pathology that eventually lead to high cardiovascular and stroke risk in patients with CKD, especially patients with AF and CKD(4,5). Unfortunately, the f...
Source: Circulation - December 17, 2015 Category: Cardiology Authors: Patel MR, Piccini JP Tags: Circulation Source Type: research

Rivaroxaban and other novel anticoagulants for stroke prevention in atrial fibrillation: time to embrace the future
Atrial fibrillation (AF) is now said to be at epidemic proportions.1 Although symptoms and heart failure are two of the main reasons that patients with AF suffer from reduced quality of life, thromboembolic complications, particularly stroke, remain the major determinant of significant morbidity and mortality.2 Importantly, the risk of thromboembolism (TE) is completely irrespective of symptoms, and hence the sad fact that people continue to present with catastrophic stroke in AF with no prior history of its detection.3 Appropriate anticoagulation is imperative to reduce the TE/stroke risk. Numerous large scale studies hav...
Source: Heart - February 18, 2013 Category: Cardiology Authors: Rajappan, K. Tags: Drugs: cardiovascular system, Epidemiology Editorials Source Type: research

The “know your numbers” program in Atahualpa — A pilot study aimed to reduce cardiovascular diseases and stroke burden in rural communities of developing countries
The burden of cardiovascular diseases and stroke is steadily increasing in many low- and middle-income countries, to the point that these conditions have been considered as the new epidemics of the developing world . The World Health Organization has set a global goal of reducing deaths from non-communicable diseases (including stroke and ischemic heart disease) by 25% by 2025 . It seems that people living in rural communities are most vulnerable to these “new epidemics”. There, a process of epidemiologic transition is aggravated by poor access to medical care and by income issues that preclude people to afford the cos...
Source: International Journal of Cardiology - May 6, 2013 Category: Cardiology Authors: Oscar H. Del Brutto, Martha Montalván, Daniel Tettamanti, Ernesto Peñaherrera, Rocío Santibáñez, Freddy Pow-Chon-Long, Victor J. Del Brutto Tags: Letters to the Editor Source Type: research

Smoking, atrial fibrillation, and ischemic stroke: a confluence of epidemics
Purpose of review: Smoking and atrial fibrillation are major contemporary health concerns. They commonly coexist and are frequent causes of ischemic stroke. The purpose of this article is to describe recent scientific investigations about smoking, atrial fibrillation, and ischemic stroke, with a primary focus on prevention. Recent findings: Smoking predisposes to atrial fibrillation and is useful for the prediction of future atrial fibrillation. Several recent risk prediction models for adverse events associated with atrial fibrillation include smoking as a component. Smoking status identifies patients at high risk of inci...
Source: Current Opinion in Cardiology - August 11, 2015 Category: Cardiology Tags: PREVENTION: Edited by Andrew Pipe Source Type: research

Atrial Cardiopathy: Redefining Stroke Risk Beyond Atrial Fibrillation
Atrial fibrillation (AF) and ischemic stroke are dual epidemics in society, both associated with poor clinical outcomes, patient disability, and significant healthcare expenditure. The conditions are interrelated and share complex causal pathways. Risk stratification algorithms such as the CHADS2 and CHA2DS2-VASc score offer predictive value in stroke and systemic embolism risk in the AF population, however, have limitations. Recent evidence suggests that an intrinsically prothrombotic atrial substrate may precede and promote AF and lead to thromboembolic events independent of the arrhythmia, allowing for a window of inter...
Source: The American Journal of Cardiology - June 28, 2023 Category: Cardiology Authors: Jessica Chu Zhang, Aditya Bhat Source Type: research

Recent advances in the epidemiology, outcome, and prevention of myocardial infarction and stroke in sub-Saharan Africa
The early part of the new millennium witnessed reports of a growing burden of cardiovascular disease in Sub-Saharan Africa (SSA). However the contribution of ischemic heart disease and stroke to this increasing burden relative to that caused by hypertensive heart disease, cardiomyopathy and rheumatic heart disease was not clear. Over the last decade, data from the continent has begun to clarify this issue and suggests three main points. The burden of ischemic heart disease relative to other causes of heart disease remains low particularly in the black Africans majority. Stroke caused predominantly by hypertension is now a ...
Source: Heart - August 2, 2013 Category: Cardiology Authors: Ntsekhe, M., Damasceno, A. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Global burden of cardiovascular disease Source Type: research

Prevalence and Outcomes of Acute Ischemic Stroke Among Patients ≤ 50 Years of Age with Laboratory Confirmed COVID-19 Infection
The COVID-19 epidemic has led to an unpreceded disruption in health care systems worldwide. Concerns have been recently raised about young patients with COVID-19 presenting with large ischemic strokes.1 Data on stroke in COVID-19 patients remain limited to a few case reports.1 In this focused analysis, we investigated the incidence and outcomes of acute ischemic stroke in young adults using a multinational database.
Source: The American Journal of Cardiology - June 13, 2020 Category: Cardiology Authors: Frank Annie, Mark C. Bates, Aravinda Nanjundappa, Deepak L. Bhatt, Mohamad Alkhouli Source Type: research

Prevalence and Outcomes of Acute Ischemic Stroke Among Patients ≤50 Years of Age With Laboratory Confirmed COVID-19 Infection
The COVID-19 epidemic has led to an unpreceded disruption in health care systems worldwide. Concerns have been recently raised about young patients with COVID-19 presenting with large ischemic strokes.1 Data on stroke in COVID-19 patients remain limited to a few case reports.1 In this focused analysis, we investigated the incidence and outcomes of acute ischemic stroke in young adults using a multinational database.
Source: The American Journal of Cardiology - June 13, 2020 Category: Cardiology Authors: Frank Annie, Mark C. Bates, Aravinda Nanjundappa, Deepak L. Bhatt, Mohamad Alkhouli Source Type: research

The Metabolic Syndrome, Atrial Fibrillation and Stroke: Tackling An Emerging Epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of metabolic syndrome. Metabolic syndrome describes an association between diabetes, hypertension, obesity, dyslipidaemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory YH Lip Tags: CRV Source Type: research

The metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

Metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

‘Pill-in-the-pocket’ Oral Anticoagulation Guided by Daily Rhythm Monitoring for Stroke Prevention in Patients with AF: A Systematic Review and Meta-analysis
AF is the most common sustained cardiac arrhythmia and is seen as a health epidemic.1 In Europe, one in three individua ls aged ≥55 years will develop AF at some point in the future.2 AF-related strokes account for approximately one-quarter of all strokes.3,4 Lifelong oral anticoagulation (OAC) remains the cornerstone of...
Source: Radcliffe Cardiology - March 2, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research

Why should we screen for atrial fibrillation?
Atrial fibrillation (AF) constitutes an increasing challenge to the medical community and healthcare providers. With a prevalence of almost 3% in the adult Swedish population1 and a forecasted twofold or threefold increase by 2050 in the USA, we are facing a diagnosis with epidemic proportions. Apart from increased mortality, AF also increases the risk of heart failure, hospitalisations and ischaemic stroke.2 Of these complications, ischaemic stroke gives a particularly heavy burden on patients, their family and society. Ischaemic stroke is the most common reason for permanent neurological disability in the adult Western p...
Source: Heart - December 8, 2016 Category: Cardiology Authors: Svennberg, E., Engdahl, J. Tags: Press releases, Drugs: cardiovascular system, Epidemiology Editorials Source Type: research

Quantitative assessment of atrial conduit function: a new index of diastolic dysfunction
Conclusions Our study confirms that LACV contribution to stroke volume increases along with worsening DD, as assessed in the context of (near) constant-volume four-chamber heart physiology. Thus, LACV can serve as new parameter for DD grading severity in HF patients.
Source: Clinical Research in Cardiology - June 30, 2015 Category: Cardiology Source Type: research

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