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Clinical Characteristics and Outcomes of Chagas Disease in the United States: A Multicenter Retrospective Analysis
Am J Trop Med Hyg. 2023 Sep 11:tpmd230361. doi: 10.4269/ajtmh.23-0361. Online ahead of print.ABSTRACTChagas disease affects approximately 300,000 patients in the United States. We evaluated a multicenter U.S.-based network to obtain clinical characteristics and outcomes of chronic Chagas disease by disease forms. This was a U.S.-based, multicenter, population-based, retrospective cohort study. We queried TriNetX, a global research network, to identify patients with dual-positive IgG serology for Trypanosoma cruzi. We captured outcomes of interest for up to 5 years. We found 429 patients with evidence of dual-positive T. cr...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Andr és F Henao-Martínez Christian Olivo-Freites Nelson I Agudelo Higuita Carolina Ferraz Carlos Franco-Paredes Jose Tuells Laila Woc-Colburn Salvador Villalpando-Carri ón Daniel B Chastain Anis Rassi Source Type: research

Safety of Temporary Interruption of Antiplatelet Therapy in Dengue Fever with Thrombocytopenia
Dengue fever, caused by a flavivirus transmitted by Aedes mosquitoes, is endemic in more than 100 countries with 2.5 billion people at risk.1 With climate change and globalization causing geographical expansion of Aedes mosquitoes, increased exposure especially in dengue-na ïve populations is predicted.2,3 Thrombocytopenia commonly occurs with dengue 4 and may be associated with bleeding. Avoidance of intramuscular injections, bed rest and measures to reduce risk of falls are usually advised. Increasingly, dengue occurs in older adults,5–7 and adult patients with de ngue fever may have comorbidities such as ischemic hea...
Source: Journal of Infection - November 30, 2020 Category: Infectious Diseases Authors: Po Ying Chia, Htet Lin Htun, Yee Sin Leo, David Chien Lye Source Type: research

Multiple neurocysticercosis and aneurismal subarachnoid hemorrhage: case presentation and systematic literature review.
Authors: Meregildo ED Abstract Neurocysticercosis (NCC) is a global health problem. In more developed countries, NCC is mainly a disease affecting immigrants. In developing countries, NCC is the most common parasitic disease of the nervous system and the main cause of acquired epilepsy. NCC is also an unrecognized cause of strokes and could account for 4%-12% of strokes. Here, I report a case of a 58-year-old woman who presented to the emergency department (ED) with severe headache, vomiting, and sudden loss of consciousness. Multiple NCC and Fisher grade 4 aneurysmal subarachnoid hemorrhage (SAH) were demonstrated...
Source: Infezioni in Medicina - June 4, 2020 Category: Infectious Diseases Tags: Infez Med Source Type: research

The Interaction Between Sickle Cell Disease and HIV Infection: A Systematic Review
Human immunodeficiency virus (HIV) and sickle cell disease (SCD) are regarded as endemic in overlapping geographic areas; however, for most countries only scarce data on the interaction between HIV and SCD and disease burden exist. HIV prevalence in SCD patients varies between 0% and 11.5% in published studies. SCD has been suggested to reduce disease progression of HIV into AIDS. Various interactions of antiretroviral therapy with SCD exist. Both SCD and HIV act as common risk factors for stroke, avascular necrosis, severe splenic dysfunction, pulmonary arterial hypertension, and sepsis, which may result in synergistic in...
Source: Clinical Infectious Diseases - January 23, 2015 Category: Infectious Diseases Authors: Owusu, E. D. A., Visser, B. J., Nagel, I. M., Mens, P. F., Grobusch, M. P. Tags: HIV/AIDS Source Type: research

Neurological melioidosis in Norway presenting with a cerebral abscess
We present a case of neurological melioidosis, presenting with a cerebral abscess in a returning traveler from an endemic area. While traveling in Cambodia on holiday, the patient was admitted to local hospital for pneumonia. Her condition improved after antimicrobial treatment, and she returned to Norway when discharged. The patient had several contacts with the health care system after returning to Norway, due to recurrent fever and deterioration. Short-term antimicrobial treatment was given with temporary improvement in her condition. Eventually she developed stroke-like symptoms, and a cerebral abscess was found. Cultu...
Source: IDCases - December 3, 2014 Category: Infectious Diseases Source Type: research

Neurological Melioidosis in Norway- presenting with a Cerebral Abscess
We present a case of neurological meliodosis, presenting with a cerebral abscess in a returning traveler from an endemic area. While travelling in Cambodia on holiday, the patient was admitted to local hospital for pneumonia. Her condition improved after antimicrobial treatment, and she returned to Norway when discharged. The patient had several contacts with the health care system after returning to Norway, due to recurrent fever and deterioration. Short term antimicrobial treatment was given with temporary improvement in her condition. Eventually she developed stroke-like symptoms, and a cerebral abscess was found. Cultu...
Source: IDCases - November 24, 2014 Category: Infectious Diseases Source Type: research