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Specialty: Biochemistry
Infectious Disease: Pandemics
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Total 1075 results found since Jan 2013.
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research
Discovery of a potent inhibitor targeting the cap-binding domain of the PB2 subunit of influenza RNA-dependent RNA polymerase
Biochem Biophys Res Commun. 2023 Aug 12;678:97-101. doi: 10.1016/j.bbrc.2023.08.027. Online ahead of print.ABSTRACTInfluenza pandemics have emerged as a significant global public health and security concern. PB2, a crucial subunit of the influenza RNA-dependent RNA polymerase (RdRP), has been identified as a promising target for influenza treatment. We herein report the discovery of a potent novel PB2 inhibitor, 7-51A, with a KD value of 1.64 nM as determined by ITC. The high activity of 7-51A was elucidated by the co-crystal structure of the PB2-7-51A complex, and comparative analysis revealed unique interactions that had...
Source: Biochemical and Biophysical Research communications - August 25, 2023 Category: Biochemistry Authors: Weining Sun Ziling Zhang Mingxin Chen Xinlei Liu Yifei Wang Shaohua Yao Linli Li Source Type: research
Photodegradation of polylactic acid: Characterisation of glassy and melt behaviour as a function of molecular weight
In this study, we investigated the effects of long-term exposure to UV-C irradiation on the properties of PLA and interpreted the results at the molecular scale. We performed gel permeation chromatography, FTIR and UV-Vis spectroscopy to analyse changes in chemical structure induced by the UV-irradiation. Then, we carried out thermal, rheological and tensile tests to investigate mechanical and melting properties, and we investigated the applicability of these test results to estimate molecular weight loss. We have created a 3D irradiation map that can facilitate the design of disinfection devices. Based on our results, we ...
Source: International Journal of Biological Macromolecules - August 16, 2023 Category: Biochemistry Authors: Ábris Dávid Virág Csenge T óth Kolos Moln ár Source Type: research
An immune-enhanced multivalent DNA nanovaccine to prevent H7 and H9 avian influenza virus in mice
Int J Biol Macromol. 2023 Aug 12:126286. doi: 10.1016/j.ijbiomac.2023.126286. Online ahead of print.ABSTRACTH7 avian influenza virus has caused multiple human infections and poses a severe public health threat. In response to the highly variable nature of AIVs, a novel, easily regenerated DNA vaccine has great potential in treating or preventing avian influenza pandemics. Nevertheless, DNA vaccines have many disadvantages, such as weak immunogenicity and poor in vivo delivery. To further characterize and solve these issues and develop a novel H7 AIV DNA vaccine with enhanced stability and immunogenicity, we constructed nin...
Source: International Journal of Biological Macromolecules - August 14, 2023 Category: Biochemistry Authors: Shangen Xu Hailing Lan Qiaoyang Teng Xuesong Li Zheng Jin Yang Qu Jiawei Li Qihong Zhang Hong Kang Tan Hui Yin Zejun Li Kai Zhao Source Type: research
Conventional understanding of SARS-CoV-2 Mpro and common strategies for developing its inhibitors
Chembiochem. 2023 Aug 14:e202300301. doi: 10.1002/cbic.202300301. Online ahead of print.ABSTRACTThe COVID-19 pandemic has brought a widespread influence on the world, especially in the face of sudden coronavirus infections, and there is still an urgent need for specific small molecule therapies to cope with possible future pandemics. The pathogen responsible for this pandemic is SARS-CoV-2, and understanding its structure and lifecycle is beneficial for designing specific drugs of treatment for COVID-19. The main protease (Mpro) which has conservative and specific advantages is essential for viral replication and transcrip...
Source: Chembiochem - August 14, 2023 Category: Biochemistry Authors: Kun Zhou Daquan Chen Source Type: research
SARS-CoV-2 variants, its recombinants and epigenomic exploitation of host defenses
Biochim Biophys Acta Mol Basis Dis. 2023 Aug 5:166836. doi: 10.1016/j.bbadis.2023.166836. Online ahead of print.ABSTRACTSince 2003, we have seen the emergence of novel viruses, such as SARS-CoV-1, MERS, ZIKA, swine flu virus H1N1, Marburg, Monkeypox, Ebola, and SARS-CoV-2, but none of them gained pandemic proportions similar to SARS-CoV-2. This could be attributed to unique viral traits, allowing its rapid global dissemination following its emergence in October 2019 in Wuhan, China, which appears to be primarily driven by the emergence of highly transmissible and virulent variants that also associate, in some cases, with s...
Source: Biochimica et Biophysica Acta - August 7, 2023 Category: Biochemistry Authors: Nitin K Saksena Srinivas Bonam Reddy Monica Miranda-Saksena Thyago H S Cardoso Edson M A Silva Juliana C Fereira Wael M Rabeh Source Type: research
Aggregation induced nucleic acids recognition by homodimeric asymmetric monomethyne cyanine fluorochromes in mesenchymal stem cells
Int J Biol Macromol. 2023 Aug 4:126094. doi: 10.1016/j.ijbiomac.2023.126094. Online ahead of print.ABSTRACTIn the light of recent retrovirus pandemics, the issue of discovering new and diverse RNA-specific fluorochromes for research and diagnostics became of acute importance. The great majority of nucleic acid-specific probes either do not stain RNA or cannot distinguish between DNA and RNA. The versatility of polymethine dyes makes them suitable as stains for visualization, analysis, and detection of nucleic acids, proteins, and other biomolecules. We synthesized the asymmetric dicationic homodimeric monomethine cyanine d...
Source: International Journal of Biological Macromolecules - August 6, 2023 Category: Biochemistry Authors: Nikolay Ishkitiev Marina Miteva Maria Micheva Tanya Stoyanova Vesela V Lozanova Valentin S Lozanov Zornitsa Mihaylova Diana V Cheshmedzhieva Meglena Kandinska Miroslav Rangelov Nadezhda Todorova Sonia Ilieva Stanislav Baluschev Raimundo Gargallo Bogdan Ca Source Type: research
Towards the CSNK2 phosphoproteome - With lessons from the COVID-19 pandemic to revealing the secrets of CSNK2 and its promise as a therapeutic target
Biochim Biophys Acta Gen Subj. 2023 Aug 3:130441. doi: 10.1016/j.bbagen.2023.130441. Online ahead of print.ABSTRACTDramatic advances in phosphoproteomics and the development of a selective chemical probe have presented new opportunities for revealing the cellular landscape of substrates for CSNK2 (formerly known as CK2 or casein kinase II). In addition to deciphering the role(s) of CSNK2 in physiology and pathophysiology, the CSNK2 phosphoproteome offers the promise of instructing the development of CSNK2-targeted therapy.PMID:37543358 | DOI:10.1016/j.bbagen.2023.130441
Source: Biochimica et Biophysica Acta - August 5, 2023 Category: Biochemistry Authors: David W Litchfield Laszlo Gyenis Daniel Menyhart Scott E Roffey Source Type: research
Insights into the central role of N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU) in peptidoglycan metabolism and its potential as a therapeutic target
Biochem J. 2023 Jun 18;480(15):1147-1164. doi: 10.1042/BCJ20230173.ABSTRACTSeveral decades after the discovery of the first antibiotic (penicillin) microbes have evolved novel mechanisms of resistance; endangering not only our abilities to combat future bacterial pandemics but many other clinical challenges such as acquired infections during surgeries. Antimicrobial resistance (AMR) is attributed to the mismanagement and overuse of these medications and is complicated by a slower rate of the discovery of novel drugs and targets. Bacterial peptidoglycan (PG), a three-dimensional mesh of glycan units, is the foundation of th...
Source: The Biochemical Journal - July 27, 2023 Category: Biochemistry Authors: Vijay Soni Eric H Rosenn Ramya Venkataraman Source Type: research
