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Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation. "Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Leading the hunt for a COVID-19 vaccine
 Paul Stoffels, J&J ’s Chief Scientific Officer, has given delegates ateyeforpharma ’s Barcelona Virtual conference exclusive insights into its rapid progress in the search for a vaccine to the COVID-19 virus. Speaking to Reuters News on day two of the five-day conference, Stoffels said J&J ’s potential vaccine, which has just been chosen as a lead candidate to help tackle the pandemic, could be ready for clinical trials as soon as early September with evidence of its safety and efficacy expected by the end of the year.  This means that the first vaccinations could be given in the first quarter of 2021. ...
Source: EyeForPharma - April 1, 2020 Category: Pharmaceuticals Authors: Andrew Stone Source Type: news

Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial
Conclusions: These finding suggest that Poly-ICLC could be safely used for inducing transient innate immune responses in treated HIV+ subjects indicating promise as an adjuvant for HIV therapeutic vaccines. Trial Registration: www.ClinicalTrials.gov, identifier: NCT02071095. Introduction Innate immune dysregulation during HIV infection hinders the formation of anti-HIV adaptive immunity (1–6) resulting in rampant viral dissemination and progression to AIDS. Adherence to combination anti-retroviral therapy (cART) regimens controls viremia, restores CD4+T cell counts and reverses immune dysfunction to ...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Fight Aging! Newsletter, May 28th 2018
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impact on...
Source: Fight Aging! - May 27, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bill Gates Commits $12 Million To Help Find A Universal Flu Vaccine
BOSTON (CBS Local) – After a devastating flu season around the world, Bill Gates is joining the search for a universal vaccine for the potentially deadly virus. The Details: Bill Gates is offering $12 million in grants to help create a universal flu vaccine Gates made the announcement on April 27 while warning about the risk of a global pandemic The CDC says the 2017-18 flu season has killed 160 children, the most in the U.S. since 2013  In a conference at the Seaport Hotel & World Trade Center in Boston on April 27, Gates stressed the need for new treatments and a better global response to future pandemics....
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 4, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Bill Gates Chris Melore Flu Flu Vaccine Local TV Medicine talkers Source Type: news

Fight Aging! Newsletter, February 12th 2018
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - February 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

To Cure Aging as Though it Were a Disease
Aging and cancer are conceptually similar in many ways, and by this I mean that they are both collections of processes that are fundamental to the way in which the biology of complex organisms works. They are not states that can be cured or eliminated through medicine as we presently understand it, but the aspiration is instead to bring these undesirable outcomes under control - to continually cut back the offshoots, to suppress the causes, and nip in the bud the results of those causes in their earliest stages. To actually cure either aging or cancer, to remove it from the human condition, would require a radical reworkin...
Source: Fight Aging! - February 6, 2018 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, August 7th 2017
Discussions of radical life extension, technological acceleration, and artificial general intelligence were far more fringe concerns back then than is now the case, but this growth in awareness isn't a coincidence. Visions slowly become reality because people work to make that happen. Technological progress is not accidental: it is led by our desires. I should say that de Magalhães is here generous in not passing judgement on the value (or lack thereof) of most of the various ventures and classes of approach he surveys. But some approaches are definitely better than others, and to my eyes one the principal challeng...
Source: Fight Aging! - August 6, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Most Exciting Health Stories Of 2014
While 2014 will forever be known as the year of the world's biggest Ebola outbreak -- and the first cases of Ebola contracted in the United States -- the virus is just one of several impactful changes in our medical and personal health landscape. From cancer research breakthroughs to innovative food policies to strides in the search for an HIV vaccine, we're quite a bit further in our understanding of medicine than we were last year. Thanks to research in 2014... Your Fitness Tracker Data Could Lead To The Next Big Medical Discovery Your FitBit, Jawbone and other personal tracking devices and apps are logging every s...
Source: Science - The Huffington Post - December 16, 2014 Category: Science Source Type: news