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Vaccination: Malaria Vaccine
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Total 511 results found since Jan 2013.
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Preliminary studies on the immunogenicity of a prime-and-trap malaria vaccine in nonhuman primates
Vaccine. 2023 Aug 8:S0264-410X(23)00913-1. doi: 10.1016/j.vaccine.2023.07.067. Online ahead of print.ABSTRACTDevelopment of next-generation vaccines against Plasmodium falciparum (Pf) is a priority. Many malaria vaccines target the pre-erythrocytic sporozoite (SPZ) and liver stages. These include subunit vaccines based on the Pf circumsporozoite protein (CSP) and attenuated PfSPZ vaccines. However, these strategies require 3-4 doses and have not achieved optimal efficacy against field-transmitted malaria. Prime-and-trap is a recently developed two-step heterologous vaccine strategy that combines priming with DNA encoding C...
Source: Vaccine - August 10, 2023 Category: Allergy & Immunology Authors: Melanie J Shears Felicia N Watson Brad C Stone Irene Cruz Talavera Chaitra Parthiban Jokichi Matsubara Natasha Kc B Kim Lee Sim Stephen L Hoffman Sean C Murphy Source Type: research
Malaria vaccines to moderate the impact of antibiotic resistance in endemic countries
J Med Microbiol. 2023 Jul;72(7). doi: 10.1099/jmm.0.001734.ABSTRACTSwift and widespread deployment of an efficient malaria vaccine in Pakistan, together with basic control and preventive measures, could significantly decrease the economic and healthcare burden caused by drug-resistant malaria. Moreover, the RTS,S/AS01 vaccine has provided a much needed breakthrough after decades of growth, as an innovative vaccine for malaria in phase 3 clinical trials and currently undergoing implementation studies. Vaccination is a potentially critical component of efforts to arrest the development and dissemination of antimicrobial resi...
Source: Journal of Medical Microbiology - July 26, 2023 Category: Microbiology Authors: Maria Khan Saba Khan Source Type: research
HBV Infection Is an Intermediate-Risk Disease, Whereas Anaemia Is a Mild-to-Moderate Public Health Problem in Young Ghanaian Adults: A Four-Year Retrospective Analysis of Students' Medical Records
CONCLUSION: Intentional preventative public health campaigns regarding anaemia, HBV, and HCV infection should, respectively, target females and young adult males to increase chances of making real change in behavioural attitudes in these at-risk groups.PMID:37475793 | PMC:PMC10356218 | DOI:10.1155/2023/9318984
Source: Biomed Res - July 21, 2023 Category: Research Authors: Samuel Amoah Andrew Nicholas Yartey Praise Fosu Adjei Margaret Owusu-Akyaw Joseph Boachie David Larbi Simpong Patrick Adu Source Type: research
The immunity modulation of transforming growth factor- β in malaria and other pathological process
Int Immunopharmacol. 2023 Jul 17;122:110658. doi: 10.1016/j.intimp.2023.110658. Online ahead of print.ABSTRACTThe main causative agent of malaria in humans is Plasmodium falciparum, which is spread through biting Anopheles mosquitoes. Immunoregulation in the host involving the pleiotropic cytokine transforming growth factor-β (TGF-β) has a vital role in controlling the immune response to P. falciparum infection. Based on a search of the published literature, this study investigated the correlation between malaria and immune cells, specifically the role of TGF-β in the immune response. The studies analyzed showed that, w...
Source: International Immunopharmacology - July 19, 2023 Category: Allergy & Immunology Authors: Shuang Wu Qing Nie Shuang Tan Guoyan Liao Yinyi Lv Caohua Lv Guang Chen Shuangchun Liu Source Type: research
Plasmodium knowlesi circumsporozoite protein: genetic characterisation and predicted antigenicity of the central repeat region
This study aims to characterise the CSP repeat motifs of P. knowlesi isolates in Peninsular Malaysia. CSP repeat motifs of 64 P. knowlesi isolates were identified using Rapid Automatic Detection and Alignment of Repeats (RADAR). Antigenicity of the repeat motifs and linear B cell epitopes were predicted using VaxiJen 2.0, BepiPred-2.0 and BCPred, respectively. A total of 35 dominant repeat motifs were identified. The repeat motif "AGQPQAQGDGANAGQPQAQGDGAN" has the highest repeat frequency (n=15) and antigenicity index of 1.7986. All the repeat regions were predicted as B cell epitopes. In silico approaches revealed that al...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: J H Tan F W Cheong Y L Lau M Y Fong Source Type: research
