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Neuronal AR regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess
Endocrinology. 2023 Sep 21:bqad141. doi: 10.1210/endocr/bqad141. Online ahead of print.ABSTRACTHyperandrogenemia and polycystic ovarian syndrome are a result of the imbalance of androgen levels in females. Androgen receptor (Ar) mediates the effect of androgen, and this study examines how neuronal Ar in the central nervous system (CNS) mediates metabolism under normal and increased androgen conditions in female mice. The neuron specific ARKO mouse (SynARKO) was created from female (Ar fl/wt; synapsin promoter driven Cre) and male (Ar fl/y) mice. Glucose tolerance test revealed impaired glucose tolerance that was partially ...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Vaibhave Ubba Serene Joseph Olubusayo Awe Dustin Jones Milan K Dsilva Mingxiao Feng Junjiang Wang Xiaomin Fu Razeen J Akbar Brittany H Bodnar Wenhui Hu Hong Wang Xiaofeng Yang Ling Yang Peixin Yang Rexford Ahima Sara Divall Sheng Wu Source Type: research
Adipocyte glucocorticoid receptor inhibits immune regulatory genes to maintain immune cell homeostasis in adipose tissue
Endocrinology. 2023 Sep 20:bqad143. doi: 10.1210/endocr/bqad143. Online ahead of print.ABSTRACTGlucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood. We performed in vivo studies using adipocyte sp...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Shripa Amatya Dylan Tietje-Mckinney Schaefer Mueller Maria G Petrillo Matthew D Woolard Sushma Bharrhan A Wayne Orr Christopher G Kevil John A Cidlowski Diana Cruz-Topete Source Type: research
Development and psychometric validation of the gum health experience questionnaire
CONCLUSIONS: The gum health experience questionnaire holds substantial promise as a measure of gum-related quality of life in people across the gum health-disease continuum. Further face validity, refining and reducing the number of items and longitudinal studies to test evaluative properties are required before the measure can be used with confidence.PMID:37735867 | DOI:10.1111/jcpe.13878
Source: Journal of Clinical Periodontology - September 22, 2023 Category: Dentistry Authors: T Broomhead B J Gibson C Parkinson P G Robinson M V Vettore S R Baker Source Type: research
Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
Evaluating the dosimetric effect of intra-fractional variations in deep inspiration breath-hold radiotherapy - a proof-of-concept study
Acta Oncol. 2023 Sep 22:1-5. doi: 10.1080/0284186X.2023.2259084. Online ahead of print.NO ABSTRACTPMID:37738385 | DOI:10.1080/0284186X.2023.2259084
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: K H åkansson M Josipovic W Ottosson C P Behrens I R Vogelius G Persson Source Type: research
ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
CONCLUSION: Our results showed that the transcriptional expression of EphA7 was increased by activated STAT3, and the STAT3 signaling may act through EphA7 to promote the development of ESCC.PMID:37738252 | DOI:10.1080/0284186X.2023.2259601
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Li Wang Qiao-Feng Zhao Bing-Bing Yang Hui-Jie Liang Xian-E Zhang Xiao-Yan Zhang Wan-Jing Yang Zhi-Yu Guo Xin Xu Fang Tian Qing-Hua Wu Source Type: research
METTL5-mediated 18S rRNA m < sup > 6 < /sup > A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression
Mol Ther. 2023 Sep 20:S1525-0016(23)00501-4. doi: 10.1016/j.ymthe.2023.09.014. Online ahead of print.ABSTRACTIntrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression. While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications promotes ICC development, the role of rRNA modifications remains elusive. Here, we found that 18S rRNA m6A modification and its methyltransferase METTL5 were aberrantly upregulated in ICC and associated with poorer survival (Log rank test, p<0.05). We further revealed the critical role of METTL5-mediated 18S rRNA m6A modification in regulation...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zihao Dai Wanjie Zhu Yingdong Hou Xinyue Zhang Xuxin Ren Kai Lei Junbin Liao Haining Liu Zhihang Chen Sui Peng Shaoqiang Li Shuibin Lin Ming Kuang Source Type: research
The long non-coding RNA BBOX1 antisense RNA 1 is upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian granulose cells : Short title: BBOX1 antisense RNA 1 in cell proliferation
CONCLUSION: BBOX1-AS1 is highly upregulated in PCOS, and it may serve as an endogenous competing RNA for miR-19b to suppress its role in inhibiting granulosa cell proliferation. Our study suggested the role of BBOX1-AS1 as a potential target to treat PCOS.PMID:37735639 | DOI:10.1186/s12905-023-02632-5
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zhi Zhou Yong Zhang Can Tan Juan Zhang Guohui Yi Bangbei Wang Yejuan Li Hui Lu Weiying Lu Xiaopo Zhang Source Type: research
Preoperative treatment with mFOLFIRINOX or Gemcitabine/Nab-paclitaxel +/- isotoxic high-dose stereotactic body Radiation Therapy (iHD-SBRT) for borderline resectable pancreatic adenocarcinoma (the STEREOPAC trial): study protocol for a randomised comparative multicenter phase II trial
DISCUSSION: This trial will help define the best neoadjuvant treatment sequence for borderline resectable PDAC and aims to evaluate if a total neoadjuvant treatment integrating iHD-SBRT improves the patients' oncological outcomes.TRIAL REGISTRATION: The study was registered at ClinicalTrails.gov (NCT05083247) on October 19th, 2021, and in the Clinical Trials Information System (CTIS) EU CT database (2022-501181-22-01) on July 2022.PMID:37735634 | DOI:10.1186/s12885-023-11327-x
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Christelle Bouchart Julie Navez Ivan Borbath Karen Geboes Timon Vandamme Jean Closset Luigi Moretti Pieter Demetter Marianne Paesmans Jean-Luc Van Laethem Source Type: research
ORM1 promotes tumor progression of kidney renal clear cell carcinoma (KIRC) through CALR-mediated apoptosis
This study provides us a new way to recognize the development and progression in KIRC.PMID:37735575 | DOI:10.1038/s41598-023-42962-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Gang Yu Juan Gao Weifeng Hu Dayong Hu Weibing Wang Shiquan Yang Jing Gao Source Type: research
Spatiotemporal, optogenetic control of gene expression in organoids
Nat Methods. 2023 Sep 21. doi: 10.1038/s41592-023-01986-w. Online ahead of print.ABSTRACTOrganoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of gene expression in organoids. Here we combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns. To illustrate the usefulness of our approach, we locally activated Sonic Hedgehog (SHH) signaling in an organoid model for human neurodevelopment. ...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ivano Legnini Lisa Emmenegger Alessandra Zappulo Agnieszka Rybak-Wolf Ricardo Wurmus Anna Oliveras Martinez Cledi Cerda Jara Anastasiya Boltengagen Tal é Hessler Guido Mastrobuoni Stefan Kempa Robert Zinzen Andrew Woehler Nikolaus Rajewsky Source Type: research
A H3K27M-targeted vaccine in adults with diffuse midline glioma
Nat Med. 2023 Sep 21. doi: 10.1038/s41591-023-02555-6. Online ahead of print.ABSTRACTSubstitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses that control H3K27M+ tumors in major histocompatibility complex-humanized mice. Here we describe a first-in-human treatment with H3K27M-vac of eight adult patients with progressive H3K27M+ diffuse midline glioma on a compassionate use basis. Five patients received H3K27M-vac combined with anti-PD-1 treat...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Niklas Grassl Isabel Poschke Katharina Lindner Lukas Bunse Iris Mildenberger Tamara Boschert Kristine J ähne Edward W Green Ingrid H ülsmeyer Simone J ünger Tobias Kessler Abigail K Suwala Philipp Eisele Michael O Breckwoldt Peter Vajkoczy Oliver M Gra Source Type: research
Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis
ConclusionsThe low pooled prevalence of secondary surgical intervention and high pooled prevalence of resolution may support the current non-surgical management in children with non-refluxing primary megaureter. However, these results should be interpreted cautiously due to the limited available body of evidence. Future studies should overcome existing limitations of imaging methods by using standardized, comparable criteria and report outcome parameters in a quantitative manner. This would allow more sufficient data synthesis to provide evidence-based recommendations for clinical decision-making and counseling.Systematic ...
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research
Sleep in marathon and ultra-marathon runners: A brief narrative review
Conclusions: In summary, the longer the distance of a running race, the greater the importance of an optimal sleep for race performance as well as the impact of a race on sleep.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
