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Total 299 results found since Jan 2013.

Early mother-infant relationships after cardiac surgery in infancy
Conclusions Most mothers report a positive relationship with their infant following cardiac surgery but almost a quarter have difficulties forming a strong emotional tie. Clinical care (including prenatal) of the infant with congenital heart disease requiring surgery should include screening, assessment and appropriate referral for early intervention if mothers are struggling to form a bond with their infant.
Source: Archives of Disease in Childhood - June 12, 2014 Category: Pediatrics Authors: Jordan, B., Franich-Ray, C., Albert, N., Anderson, V., Northam, E., Cochrane, A., Menahem, S. Tags: Congenital heart disease, Drugs: cardiovascular system, Stroke, Pregnancy, Reproductive medicine, Child and adolescent psychiatry (paedatrics), Mood disorders (including depression), Screening (epidemiology), Screening (public health) Original article Source Type: research

Trier social stress test in Indian adolescents.
CONCLUSIONS: The TSST-C produces stress responses in Indian adolescents of a sufficient magnitude to be a useful tool for examining stress physiology and its relationships to disease outcomes in this population. PMID: 24986282 [PubMed - in process]
Source: Indian Pediatrics - June 8, 2014 Category: Pediatrics Authors: Krishnaveni GV, Veena SR, Jones A, Bhat DS, Malathi MP, Hellhammer D, Srinivasan K, Upadya H, Kurpad AV, Fall CH Tags: Indian Pediatr Source Type: research

Hypothermia did not improve mortality or disability in severe traumatic brain injury
Study design Design: Randomised controlled trial (RCT). Allocation: Concealed web based algorithm to stratified by study site and age. Blinding: Treating doctors not masked—investigators assessing outcome were masked. Study question Setting: Multinational, multicentre paediatric intensive care unit—75% patients from three paediatric intensive care units (Davis, California; Dallas, Texas; Pittsburgh, Pennsylvania) in USA. Patients: Age 0–17 years non-penetrating brain injury; Glasgow coma scale (GCS) score 3–8 (motor score <6), available for randomisation within 6 h of injury. Excluded i...
Source: Archives of Disease in Childhood - Education and Practice - May 14, 2014 Category: Pediatrics Authors: Tasker, R. C. Tags: Clinical trials (epidemiology), Epidemiologic studies, Coma and raised intracranial pressure, Neurological injury, Stroke, Hypertension, Pregnancy, Reproductive medicine, Child health, Neonatal and paediatric intensive care, Neonatal health, Trauma, Injur Source Type: research

Headache does not equal stroke in sickle cell
Headache is a common complaint in children with sickle cell disease. Dowling et al conducted a planned secondary analysis from the Silent Infarct Transfusion Trial to determine whether recurrent headache or, more specifically, migraine were predictive of silent cerebral infarction in children with sickle cell disease. In a cross-sectional study of 872 children, about one-third had headaches and 15% had migraines. Asymptomatic cerebral infarcts were not more likely in patients with recurrent headaches or migraine. As a take-home point, the authors note that neuroimaging may not be needed for children with sickle cell diseas...
Source: The Journal of Pediatrics - April 16, 2014 Category: Pediatrics Authors: Paul G. Fisher Tags: The Editors' Perspectives Source Type: research

Patient-reported quality of life outcomes for children with serious congenital heart defects
Conclusions Children with serious CHDs experience lower QoL than unaffected classmates. This appears related to the burden of clinical intervention rather than underlying cardiac diagnosis. Participation in sports activities is positively associated with increased emotional well-being. Child self-report measures of QoL would be a valuable addition to clinical outcome audit in this age group.
Source: Archives of Disease in Childhood - April 9, 2014 Category: Pediatrics Authors: Knowles, R. L., Day, T., Wade, A., Bull, C., Wren, C., Dezateux, C., On behalf of the UK Collaborative Study of Congenital Heart Defects (UKCSCHD), Adwani, Bu'Lock, Craig, Daubeney, Derrick, Elliott, Franklin, Gibbs, Knight, Lim, Magee, Martin, Miller, Qu Tags: Epidemiologic studies, Open access, Congenital heart disease, Stroke Original article Source Type: research

What Causes Ataxia?
Discussion Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy wal...
Source: PediatricEducation.org - March 31, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Cerebral vasculopathy in pediatric sickle-cell anemia.
Abstract In children with sickle-cell anemia, cerebral vasculopathy is a frequent and severe complication. It is attributed not only to erythrocyte sickling but also to multiple physiological modifications associated with sickle-cell anemia: platelet and leukocyte activation, endothelial injury and remodeling, coagulation activation, hemolysis and subsequent chronic inflammation, impaired vasomotricity, etc. Intracranial large-vessel remodeling leads to clinical cerebral infarction, whereas microvascular injury and impaired vasoreactivity lead to so-called silent infarcts, which are actually associated with impair...
Source: Archives de Pediatrie - March 12, 2014 Category: Pediatrics Authors: Kossorotoff M, Grevent D, de Montalembert M Tags: Arch Pediatr Source Type: research

Headache and Migraine in Children with Sickle Cell Disease Are Associated with Lower Hemoglobin and Higher Pain Event Rates But Not Silent Cerebral Infarction
Objective: To identify risk factors for headache and migraine in children with sickle cell disease and test the hypothesis that either or both are independently associated with silent cerebral infarcts.Study design: In this cross-sectional study, we evaluated the health history, laboratory values, and brain magnetic resonance imaging findings of participants with sickle cell disease (hemoglobinSS or hemoglobinSβ°-thalassemia) with no history of overt stroke or seizures. Participants characterized headache severity and quality. Migraine was defined by International Headache Society criteria modified for increased sensitiv...
Source: The Journal of Pediatrics - February 19, 2014 Category: Pediatrics Authors: Michael M. Dowling, Michael J. Noetzel, Mark J. Rodeghier, Charles T. Quinn, Deborah G. Hirtz, Rebecca N. Ichord, Janet L. Kwiatkowski, E. Steven Roach, Fenella J. Kirkham, James F. Casella, Michael R. DeBaun Tags: Original Articles Source Type: research

Stroke: Extreme Weather May Boost Risk
SAN DIEGO (MedPage Today) -- Dramatic weather changes boost stroke risk, whereas childhood vaccinations and exercise may reduce it, a series of studies showed.
Source: MedPage Today Pediatrics - February 18, 2014 Category: Pediatrics Source Type: news

Neonatal Seizures: Magnetic Resonance Imaging adds value in the diagnosis and prediction of neurodisability
ConclusionWe report the first cohort of term infants with seizures fully investigated by MRI. The universal use of MRI enabled a cause to be identified in 95% of cases. The probability of having NDI or recurrence of seizures was extremely low with absence of major cerebral lesions on MRI. This study demonstrates the added value of MRI for diagnosis of aetiology and the prediction of neurological outcome.This article is protected by copyright. All rights reserved.
Source: Acta Paediatrica - February 3, 2014 Category: Pediatrics Authors: Elizabeth Osmond, Amiel Billetop, Sally Jary, Marcus Likeman, Marianne Thoresen, Karen Luyt Tags: Regular Article Source Type: research

Fitting and flailing: recognition of paediatric antiphospholipid syndrome
We present two cases of paediatric APS, who presented with primary neurological events, and discuss approaches to diagnosis, interpretation of screening investigations, including antinuclear antibodies (ANA), anti-extractable nuclear antigen (ENA) antibodies and lupus anticoagulant. Possible approaches to the management of paediatric APS are discussed.
Source: Archives of Disease in Childhood - Education and Practice - January 13, 2014 Category: Pediatrics Authors: Freeman, H., Patel, J., Fernandez, D., Sharples, P., Ramanan, A. V. Tags: Immunology (including allergy), Drugs: cardiovascular system, Stroke, Screening (epidemiology), Screening (public health) Problem solving in clinical practice Source Type: research

Feasibility and Safety of Erythropoietin for Neuroprotection after Perinatal Arterial Ischemic Stroke
Conclusions: rhEPO in neonates with perinatal arterial ischemic stroke had no adverse effects on red blood cells, white blood cells, platelets counts, or coagulation. rhEPO, 3000 IU/kg in total, given during a 3-day period, appears to be a safe therapy. The beneficial effects remains to be demonstrated in a larger, randomized, double-blind, placebo-controlled trial.
Source: The Journal of Pediatrics - December 9, 2013 Category: Pediatrics Authors: Manon J. Benders, Niek E. van der Aa, Maurice Roks, Henrica L. van Straaten, Ivana Isgum, Max A. Viergever, Floris Groenendaal, Linda S. de Vries, Frank van Bel Tags: Original Articles Source Type: research

Cardiovascular risks and management during Attention Deficit Hyperactivity Disorder treatment with methylphenidate.
Abstract Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common of the pediatric neuropsychiatric disorders. Methylphenidate is an important element of therapeutic strategies for ADHD. Clinicians are interested in the safety of methylphenidate. Because this drug raises heart rate and blood pressure, concerns have been raised about its cardiovascular safety. Concerns were based on case reports of sudden cardiac death in methylphenidate users, plausible pharmacological pathways involving well-established stimulant effects on heart rate and blood pressure. Until recently, data were limited to a num...
Source: Archives de Pediatrie - December 2, 2013 Category: Pediatrics Authors: Bange F, Le Heuzey MF, Acquaviva E, Delorme R, Mouren MC Tags: Arch Pediatr Source Type: research

Chickenpox and stroke in children: case studies and literature review
Conclusion: Chickenpox should be considered in differential diagnosis of ischemic stroke in healthy children who fit the clinical and radiological typical profile of PVCA. This article is protected by copyright. All rights reserved.
Source: Acta Paediatrica - December 1, 2013 Category: Pediatrics Authors: Filipa Reis, Patrícia Pais, José Paulo Monteiro Tags: Clinical Overview Source Type: research

Changes in Cardiac Function and Cerebral Blood Flow in Relation to Peri/Intraventricular Hemorrhage in Extremely Preterm Infants
Conclusions: Cardiac function and CBF remain stable in very preterm neonates who do not develop P/IVH during the first 3 postnatal days. In very preterm neonates developing P/IVH during this period, lower systemic perfusion and CBF followed by an increase in these variables precede the development of P/IVH. Monitoring cardiac function and cerebral rSO2 may identify infants at higher risk for developing P/IVH before the bleeding occurs.
Source: The Journal of Pediatrics - November 1, 2013 Category: Pediatrics Authors: Shahab Noori, Michael McCoy, Michael P. Anderson, Faridali Ramji, Istvan Seri Tags: Original Articles Source Type: research