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Total 299 results found since Jan 2013.

Cardiac Preload Responsiveness in Children With Cardiovascular Dysfunction or Dilated Cardiomyopathy: A Multicenter Observational Study*
Conclusions: This study provides “normal” values for global end-diastolic volume index and limits of cardiac preload responsiveness in pediatric patients with cardiovascular dysfunction and dilated cardiomyopathy: 1.33 times normal global end-diastolic volume index represents the upper limit of patent cardiac preload responsiveness, with the highest expected responsiveness being below 0.67 times normal global end-diastolic volume index. The maximum response of the Frank-Starling relationship and therefore the level of no additional preload reserve is 1.33 to 1.51 times normal global end-diastolic volume index. Above 1....
Source: Pediatric Critical Care Medicine - January 1, 2015 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility
Conclusions Management among respondents is broadly in line with national guidance, although with possible overuse of brain imaging and underuse of EEG and neuropsychological assessments. A large proportion of patients in the UK remains untreated, and clinicians seem amenable to a range of RCT designs, with carbamazepine and levetiracetam the preferred active drugs.
Source: Archives of Disease in Childhood - December 15, 2014 Category: Pediatrics Authors: Mellish, L. C., Dunkley, C., Ferrie, C. D., Pal, D. K. Tags: Clinical trials (epidemiology), Open access, Epilepsy and seizures, Neuroimaging, Stroke, Child health, Drugs: psychiatry Review Source Type: research

West Virginia University Pediatric Stroke Registry: Clinical Description and Risk Factors Identification in Patients From a Rural Area
Conclusion. Patients with the most common risk factors for stroke (cardiac disease) were overrepresented. This suggests that in children receiving medical attention in rural areas less common risk factors for stroke might not be identified, increasing the risk recurrence. Increased index of suspicion is needed about pediatric stroke in rural areas, and early transfer to a tertiary care center for identification of risk factors is mandatory.
Source: Clinical Pediatrics - December 2, 2014 Category: Pediatrics Authors: Pergami, P., Thayapararajah, S. W., Seemaladinne, N. Tags: Articles Source Type: research

Z‐values of tricuspid annular plane systolic excursion in Japanese children
ConclusionsGrowth‐related normal TAPSE was studied in healthy Japanese children to obtain the TAPSE z‐value. TAPSE z‐value is one of the parameters that can be used to assess RV systolic function independent of body size.
Source: Pediatrics International - November 25, 2014 Category: Pediatrics Authors: Ikuo Hashimoto, Kazuhiro Watanabe, Hisashi Kaneda Tags: Original Article Source Type: research

Hyperbaric oxygen for neurologic indications. Action plan for multicenter trials in: stroke, traumatic brain injury, radiation encephalopathy and status migrainosus
Publication date: September–October 2012 Source:Pediatria Polska, Volume 87, Issue 5 Author(s): Harry T. Whelan , Ann K. Helms Introduction: There is great interest in using hyperbaric oxygen (HBO) to treat neurological disease. The exquisite sensitivity of neural tissue to hypoxia makes increased oxygenation attractive as a therapy for disease processes that induce ischemia, edema, and, more recently, apoptosis. Four things specifically exist as targets for future projects and clinical trials: (1) stroke (2) traumatic brain injury (3) radiation induced necrosis and (4) status migrainosus. Methods: Specific aims: Strok...
Source: Pediatria Polska - November 6, 2014 Category: Pediatrics Source Type: research

Neighborhood Poverty and Allostatic Load in African American Youth
Allostatic load (AL), a biomarker of cardiometabolic risk, predicts the onset of the chronic diseases of aging including cardiac disease, diabetes, hypertension, and stroke. Socioeconomic-related stressors, such as low family income, are associated with AL. African American youth who grow up in neighborhoods in which poverty levels increase across adolescence evince high AL. The study also highlights the benefits of emotional support in ameliorating this association. (Read the full article)
Source: PEDIATRICS - October 31, 2014 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Management and 2-year follow-up of children aged 29days to 17years hospitalized for a first stroke in France (2009-2010).
CONCLUSION: This is the first study to report the epidemiology of childhood stroke in France. The validity of this study is supported by the fact that it demonstrated homogeneous descriptive indicators to those obtained by means of various methodologies in other populations. The high mortality, recurrence, and disability rates observed during the year following the initial stroke encourage continuation of the ongoing process of standardizing the management of childhood stroke in France. PMID: 25287139 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - October 3, 2014 Category: Pediatrics Authors: Tuppin P, Samson S, Woimant F, Chabrier S Tags: Arch Pediatr Source Type: research

Pharmacological interventions for hypertension in children
Abstract BackgroundHypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data on the long‐term sequelae of persistent hypertension in children, but it is known that children with hypertension have evidence of end organ damage and are at risk of hypertension into adulthood. The prevalence of hypertension in children is rising, most likely due to a concurrent rise in obesity rates. In children with hypertension, non‐pharmacological measures are often recommended as first‐line therapy, but a significant proportion of children will eventually require ph...
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 19, 2014 Category: Pediatrics Authors: Swasti Chaturvedi, Deborah H Lipszyc, Christoph Licht, Jonathan C Craig, Rulan Parekh Tags: Intervention Review Source Type: research

Question 2: Should children who have a febrile seizure be screened for iron deficiency?
Clinical scenario You are a senior house officer working in a busy district general hospital in the UK. A 2-year-old child presents following a generalised tonic-clonic seizure that lasted around 1 min. He had recently been unwell with a cough and runny nose and was febrile at the time of the seizure. He now appears well and is running around the ward. You diagnose a simple febrile seizure secondary to a viral upper respiratory tract infection and, as it his first episode, admit him for observation. The local hospital protocol on the management of febrile seizures states no investigations are required. However, your r...
Source: Archives of Disease in Childhood - September 11, 2014 Category: Pediatrics Authors: King, D., King, A. Tags: ADC Archimedes, Epidemiologic studies, TB and other respiratory infections, Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Stroke, Malnutrition, Child and adolescent psychiatry (paedatrics), Child health Source Type: research

The z‐values of the tricuspid annular plane systolic excursion in Japanese children
ConclusionsWe studied the growth‐related normal values of the TAPSE in healthy Japanese children to obtain the z‐values of the TAPSE. We consider the z‐value of the TAPSE to be one of parameters that can be used to assess the RV systolic function independent of the body size.
Source: Pediatrics International - September 9, 2014 Category: Pediatrics Authors: Ikuo Hashimoto, Kazuhiro Watanabe, Hisashi Kaneda Tags: Original Article Source Type: research

Children Prescribed Growth Hormone May Face Stroke Risk Later: Study
Title: Children Prescribed Growth Hormone May Face Stroke Risk Later: StudyCategory: Health NewsCreated: 8/13/2014 4:35:00 PMLast Editorial Review: 8/14/2014 12:00:00 AM
Source: MedicineNet Kids Health General - August 14, 2014 Category: Pediatrics Source Type: news

Central Nervous System Complications of Varicella-Zoster Virus
Conclusion: Neurologic complications of VZV infection continue to occur despite the availability of an effective vaccine. Neurologic symptom onset can predate the appearance of the VZV exanthem and in rare cases may occur in the absence of an exanthem.
Source: The Journal of Pediatrics - July 24, 2014 Category: Pediatrics Authors: Michelle Science, Daune MacGregor, Susan E. Richardson, Sanjay Mahant, Dat Tran, Ari Bitnun Tags: Original Articles Source Type: research

Antithrombotic Therapy for Secondary Stroke Prevention in Bacterial Meningitis in Children
Conclusion: In this small sample, heparin and ASA appeared to be safe in childhood bacterial meningitis complicated by stroke and may be effective in improving outcome. Heparin may be more effective than aspirin in preventing recurrent infarction.
Source: The Journal of Pediatrics - July 24, 2014 Category: Pediatrics Authors: Cyrus Boelman, Manohar Shroff, Ivanna Yau, Bruce Bjornson, Susan Richrdson, Gabrielle deVeber, Daune MacGregor, Mahendranathn Moharir, Rand Askalan Tags: Original Articles Source Type: research

Highlights from the literature
Breastfeeding and CRP in adulthood None of us need further convincing of the benefits of breastfeeding to children's health. But can this extend long into adult life? The adult literature is full of studies demonstrating convincingly that chronic minor elevations of blood C-reactive protein (CRP) levels are an excellent predictor of major health problems such as atheroma, ischaemic heart disease and stroke. A massive longitudinal cohort study from the US related breastfeeding history to CRP levels at age 24–32 years (McDade T. Proc R Soc B 2014; doi:10.1098/rspb.2013.3116). The National Longitudinal Study of Adolesce...
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Tags: Miscellanea Source Type: research

Cerebral ultrasound abnormalities in offspring of women with C677T homozygous mutation in the MTHFR gene: a prospective study.
CONCLUSIONS: Our data confirmed a high incidence of cerebral abnormalities in neonates born to women with C677T homozygous mutation in the MTHFR gene. cUS at birth proved to be an effective screening tool or a diagnostic test, that should be routinely performed in babies born to mothers with known thrombotic predisposition. PMID: 24974211 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - June 28, 2014 Category: Pediatrics Authors: Pogliani L, Cerini C, Penagini F, Duca P, Mameli C, Zuccotti GV Tags: World J Pediatr Source Type: research