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Specialty: Neuroscience
Education: Study
Procedure: Transplants

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Total 26 results found since Jan 2013.

ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke
In this study, we transplanted exogenous NSCs into the ipsilateral hemisphere of male rats in combination with ZL006 treatment after ischemic stroke. We show that ZL006 treatment facilitates the migration of transplanted NSCs into the ischemia‐injured area and promotes neuronal differentiation of these cells, which is not due to a direct effect of ZL006 on exogenous NSCs but is associated with increased phosphorylation of cAMP response element–binding protein (CREB) in neurons and favorable microenvironment. Moreover, improved functional outcome in the ZL006‐treated group was also found. Taken together, our data indi...
Source: Journal of Neuroscience Research - May 17, 2017 Category: Neuroscience Authors: Dong ‐Liang Wang, Xiao‐Dan Qian, Yu‐Hui Lin, Bin‐Bin Tian, Hai‐Ying Liang, Lei Chang, Hai‐Yin Wu, Dong‐Ya Zhu, Chun‐Xia Luo Tags: RESEARCH ARTICLE Source Type: research

Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.
CONCLUSION: These findings highlight the therapeutic effects of EPI-NCSCs transplantation, probably through simultaneous induction of neuronal and glial formation, as well as Bdnf over-expression in a rat model of ischemic stroke. PMID: 32281225 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - April 11, 2020 Category: Neuroscience Authors: Salehi MS, Pandamooz S, Safari A, Jurek B, Tamadon A, Namavar MR, Dianatpour M, Dargahi L, Azarpira N, Fattahi S, Shid Moosavi SM, Keshavarz S, Khodabandeh Z, Zare S, Nazari S, Heidari M, Izadi S, Poursadeghfard M, Borhani-Haghighi A Tags: CNS Neurosci Ther Source Type: research

Pifithrin-α Enhances the Survival of Transplanted Neural Stem Cells in Stroke Rats by Inhibiting p53 Nuclear Translocation.
CONCLUSION: Our results indicate that PFT-α enhances the survival of grafted NSCs through the inhibition of p53 translocation into the nucleus. PMID: 23253187 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 18, 2012 Category: Neuroscience Authors: Lei XH, Zhao D, Li YL, Li XF, Sun X, Du WZ, Sun Y, Hao ZF, Xin SY, Liu C, Zhang ZR, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats
CONCLUSIONS: FG-4592 pretreated BMSCs improve neurological function recovery after stroke and are likely to be a promising strategy for stroke management.PMID:35695696 | DOI:10.1111/cns.13890
Source: CNS Neuroscience and Therapeutics - June 13, 2022 Category: Neuroscience Authors: Jiayu Chen Xiao Lin Chaojie Yao Lebohang Anesu Bingwa Hao Wang Zhongxiao Lin Kunlin Jin Qichuan Zhuge Su Yang Source Type: research

Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice
CONCLUSION: The findings indicate that MSCs overexpressing HO-1 exhibited significant therapeutic effects against hyper-inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke.PMID:37592866 | DOI:10.1111/cns.14412
Source: CNS Neuroscience and Therapeutics - August 18, 2023 Category: Neuroscience Authors: Yu Yang Qianqian Liu Song Deng Qian Shao Long Peng Yuejuan Ling Yue Huang Siqi Zheng Qiaoji Jiang Dekang Nie Jian Chen Source Type: research

Cell based therapies for ischemic stroke: From basic science to bedside
Publication date: April 2014 Source:Progress in Neurobiology, Volume 115 Author(s): Xinfeng Liu , Ruidong Ye , Tao Yan , Shan Ping Yu , Ling Wei , Gelin Xu , Xinying Fan , Yongjun Jiang , R. Anne Stetler , George Liu , Jieli Chen Cell therapy is emerging as a viable therapy to restore neurological function after stroke. Many types of stem/progenitor cells from different sources have been explored for their feasibility and efficacy for the treatment of stroke. Transplanted cells not only have the potential to replace the lost circuitry, but also produce growth and trophic factors, or stimulate the release of such factors ...
Source: Progress in Neurobiology - November 9, 2014 Category: Neuroscience Source Type: research

Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke
Neurochem Res. 2022 Jun 6. doi: 10.1007/s11064-022-03638-5. Online ahead of print.ABSTRACTIschemic stroke leads to acute neuron death and forms an injured core, triggering delayed cell death at the penumbra. The impaired brain functions after ischemic stroke are hardly recovered because of the limited regenerative properties. However, recent rodent intervention studies manipulating the extracellular environments at the subacute phase shed new light on the regenerative potency of the injured brain. This review introduces the rational design of artificial extracellular matrix (ECM) mimics using supramolecular peptidic scaffo...
Source: Neurochemical Research - June 6, 2022 Category: Neuroscience Authors: Takahiro Muraoka Itsuki Ajioka Source Type: research

Intra ‐arterial transplantation of human bone marrow mesenchymal stem cells (hBMMSCs) improves behavioral deficits and alters gene expression in rodent stroke model
In conclusion, hBMMSCs administration significantly improves the behavioral deficits by improving motor and locomotor co‐ordination. The promoter of TSP1 and WNK1 genes was found to be hyper‐methylated in hBMMSCs group resulting in their decreased expression while the promoter of ANP and BDNF was found to be hypo‐methylated. This study might shed a light on how hBMMSCs affect the gene expression by modulating methylation status. This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - October 19, 2017 Category: Neuroscience Authors: Vibhuti, Rehan Khan, Alpana Sharma, Suman Jain, Sujata Mohanty, Kameshwar Prasad Tags: Original Article Source Type: research

Dose-dependent effects of tetramethylpyrazine on the characteristics of human umbilical cord mesenchymal stem cells for stroke therapy
This study determined the dose-dependent effects of tetramethylpyrazine (TMP) on the characteristics of ucMSCs in vitro. The effect on proliferation was determined with Cell Counting kit-8 assays. Cell migration was analyzed with Transwell assays and western blot analysis. Differentiation of ucMSCs was evaluated according to markers and the expression of relevant proteins and genes. Secretion capacity was detected by ELISA analysis. TMP protected ucMSCs against H2O2 induced-oxidative damage but had no influence on ucMSC activity at a low concentration. Furthermore, ucMSC migration was improved by TMP via the SDF-1/CXCR4 ax...
Source: Neuroscience Letters - February 15, 2020 Category: Neuroscience Source Type: research

Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury.
Abstract Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death and secondary cell death closely model disease progression and worsen outcomes. Mounting evidence indicates that long-term neuroinflammation extensively exacerbates the secondary deterioration of brain structure and function. Due to their immunomodulatory and regenerative properties, mesenchymal stem cell transplants have emerged as a promising approach to treating this facet of stroke and TBI pathology. In this review, we summ...
Source: CNS Neuroscience and Therapeutics - April 30, 2020 Category: Neuroscience Authors: Bonsack B, Corey S, Shear A, Heyck M, Cozene B, Sadanandan N, Zhang H, Gonzales-Portillo B, Sheyner M, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Transplantation of modified human bone marrow-derived stromal cells affords therapeutic effects on cerebral ischemia in rats
CONCLUSION: SB623 cells with or without encapsulation showed therapeutic effects on ischemic stroke. Encapsulated SB623 cells showed enhanced neurogenesis and increased viability inside the capsules. This study reveals the mechanism of secretory function of transplanted SB623 cells, but not cell-cell interaction as primarily mediating the cells' functional benefits in ischemic stroke.PMID:36000240 | DOI:10.1111/cns.13947
Source: CNS Neuroscience and Therapeutics - August 24, 2022 Category: Neuroscience Authors: Satoshi Kawauchi Takao Yasuhara Kyohei Kin Satoru Yabuno Chiaki Sugahara Takayuki Nagase Kakeru Hosomoto Yosuke Okazaki Yousuke Tomita Michiari Umakoshi Tatsuya Sasaki Masahiro Kameda Cesario V Borlongan Isao Date Source Type: research