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Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
CONCLUSION: From these results, it was observed that CD treatment could reduce neuronal necrosis and create anti-inflammatory, anti-edema, anti-oxidant, anti-apoptotic, and anti-autophagic effects in hypoxia/reperfusion injury in rats.PMID:36548871 | DOI:10.1080/01616412.2022.2159109
Source: Neurological Research - December 22, 2022 Category: Neurology Authors: Alemiddin Ozdemir Mustafa Ogden Bahar Kartal Asli Fahriye Ceylan Ulas Yuksel Bulent Bakar Source Type: research

Neuroprotective Potency of Safranal Against Neurological Disorders
Curr Mol Med. 2022 Nov 17. doi: 10.2174/1566524023666221117104612. Online ahead of print.ABSTRACTA great number of research has been focused on plants as a source of medicine against many diseases to overcome the many side effects of chemical drugs. Safranal, one of the main constituents of saffron [Crocus sativus], has a broad spectrum of pharmacological effects, including anti-inflammatory, antioxidant, and antiapoptotic effects. The present review elaborates on the current understanding of the neuroprotective effects of safranal. According to data published so far, safranal has the potential to exert neuroprotective eff...
Source: Epilepsy Curr - November 18, 2022 Category: Neurology Authors: Elham Fazeli Mohammad Hossein Eshaghi Ghalibaf Fatemeh Forouzanfar Source Type: research

Salidroside attenuates cerebral ischemia/reperfusion injury by regulating TSC2-induced autophagy
In conclusion, SAL reduces the inflammatory response and oxidative stress in a concentration-dependent manner, and protects against cerebral I/R injury by modulating TSC2-induced autophagy. These findings suggest SAL may prove to be a potential therapeutic agent for ischemic stroke.PMID:36374318 | DOI:10.1007/s00221-022-06493-6
Source: Brain Research - November 14, 2022 Category: Neurology Authors: Chunli Li Jiejun Chi Hongyan Dai Ming Liang Yangyang Wang Songxin Tian Huiyan Zhu Hai Xu Source Type: research

Protective Effect of Ergothioneine Against Stroke in Rodent Models
AbstractErgothioneine (ET) is a naturally occurring antioxidant and cytoprotective agent that is synthesized by fungi and certain bacteria. Recent studies have shown a beneficial effect of ET on neurological functions, including cognition and animal models of depression. The aim of this study is to elucidate a possible effect of ET in rodent models of stroke. Post-ischemic intracerebroventricular (i.c.v.) infusion of ET significantly reduced brain infarct volume by as early as 1  day after infusion in rats, as shown by triphenyltetrazolium chloride (TTC) assay. There was a dose-dependent increase in protection, from 50 to...
Source: NeuroMolecular Medicine - October 19, 2022 Category: Neurology Source Type: research

The effects of the superoxide dismutase mimetic, MnTMPyP, post hypoxia and oxygen glucose deprivation, in isolated rat hippocampal slices
We report a novel modulatory effect of MnTMPyP on synaptic transmission post hypoxia and OGD, an effect specific to the CA1 region of the hippocampus. This reduction of the fEPSP by MnTMPyP post hypoxia in the CA1 was attenuated through the co-application of the adenosine A1 receptor antagonist, DPCPX (200nM), and the NMDA receptor antagonists, AP-5 (10µM) and DCKA (5µM). These effects were not observed in the OGD model. Our organotypic data demonstrated a protective role for MnTMPyP, where slices had significantly less cell death in the CA1 region post hypoxia and OGD, compared to controls. Taken together, our results s...
Source: Brain Research Bulletin - October 2, 2022 Category: Neurology Authors: Niamh Moreton Martina Puzio John J O'Connor Source Type: research

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