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Microvascular decompression for elderly patients with trigeminal neuralgia
Publication date: Available online 2 March 2016 Source:Journal of Clinical Neuroscience Author(s): Kevin Phan, Prashanth J. Rao, Mark Dexter Microvascular decompression (MVD) has been demonstrated to be an excellent surgical treatment approach in younger patients with trigeminal neuralgia (TN). However, it is not clear whether there are additional morbidity and mortality risks for MVD in the elderly population. We performed a systematic literature review using six electronic databases for studies that compared outcomes for MVD for TN in elderly (cut-off ⩾60, 65, 70years) versus younger populations. Outcomes examined...
Source: Journal of Clinical Neuroscience - March 2, 2016 Category: Neuroscience Source Type: research

The Expression and Significance of the Plasma Let-7 Family in Anti- N -methyl- d -aspartate Receptor Encephalitis
Abstract The study aimed to investigate the expression and significance of the plasma let-7 family in anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Blood samples from 5 anti-NMDAR encephalitis patients and 5 negative controls were collected for microarray analysis. Blood samples from10 anti-NMDAR encephalitis patients, 10 anti-NMDAR encephalitis patients whose physical conditions have improved after 3 months of immunotherapy, 20 virus (meningitis) encephalitis patients, 20 tuberculosis (meningitis) encephalitis patients, 10 purulent (meningitis) encephalitis patients, 20 cerebral cysticercosis patient...
Source: Journal of Molecular Neuroscience - June 23, 2015 Category: Neuroscience Source Type: research

In-depth performance analysis of an EEG based neonatal seizure detection algorithm
Full term neonates with neurological conditions such as hypoxic-ischaemic encephalopathy (HIE), stroke and meningitis are at high risk of developing seizures. There is accumulating evidence from animal models (Wirrell et al., 2001) and human studies (Glass et al., 2009) that neonatal seizures impose additional damage to the brain above and beyond the underlying aetiology. Prompt detection and treatment of seizures is therefore of paramount importance to optimize developmental outcome.
Source: Clinical Neurophysiology - February 20, 2016 Category: Neuroscience Authors: S. Mathieson, J. Rennie, V. Livingstone, A. Temko, E. Low, R.M. Pressler, G.B. Boylan Source Type: research

Pituitary aspergillus infection
We report a case of Aspergillus infection involving the pituitary gland and sellar region discovered in a 74-year-old man. The patient had a history of hypertension, chronic renal disease, autoimmune hemolytic anemia and presented with right eye pain, headaches and worsening hemiparesis. Imaging studies revealed a right internal carotid artery occlusion and an acute right pontine stroke along with smaller infarcts in the right middle cerebral artery distribution. Clinically, the patient was thought to have vasculitis. An infectious etiology was not identified. He developed respiratory distress and died. At autopsy, necroti...
Source: Journal of Clinical Neuroscience - May 29, 2016 Category: Neuroscience Source Type: research

Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
CONCLUSION: Poldip2 inhibition alleviated brain edema and preserved the integrity of BBB partially by relieving the loss of AQP4 polarity via MMPs/β-DG pathway. PMID: 32790044 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - August 11, 2020 Category: Neuroscience Authors: Gao M, Lu W, Shu Y, Yang Z, Sun S, Xu J, Gan S, Zhu S, Qiu G, Zhuo F, Xu S, Wang Y, Chen J, Wu X, Huang J Tags: CNS Neurosci Ther Source Type: research

Cerebral venous sinus thrombosis in children: A study from a tertiary care hospital of eastern India
Conclusion: CVST is an underdiagnosed but important cause of stroke in childhood, occurring most often in the neonatal period. Mortality and morbidity are significant. Infections hyper coagulative disorders are the two primary associations. Magnetic resonance venography is the investigation of choice. Early diagnosis with management along with plan for secondary prevention can save from catastrophic consequences.
Source: Journal of Pediatric Neurosciences - January 19, 2021 Category: Neuroscience Authors: Shubhankar Mishra Ashok K Mallick Geeta Mohanty Priyabrata Nayak Source Type: research