Filtered By:
Education: Lessons
Therapy: Stem Cell Therapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 289 results found since Jan 2013.
The two-step approach to allogeneic hematopoietic stem cell transplantation
Front Immunol. 2023 Sep 1;14:1237782. doi: 10.3389/fimmu.2023.1237782. eCollection 2023.ABSTRACTAllogeneic hematopoietic stem cell transplantation (HSCT) provides the only potentially curative option for multiple hematological conditions. However, allogeneic HSCT outcomes rely on an optimal balance of effective immune recovery, minimal graft-versus-host disease (GVHD), and lasting control of disease. The quest to attain this balance has proven challenging over the past few decades. The two-step approach to HSCT was conceptualized and pioneered at Thomas Jefferson University in 2005 and remains the main platform for allogra...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Sikemi Ibikunle Dolores Grosso Usama Gergis Source Type: research
Advances in acute myeloid leukemia differentiation therapy: A critical review
Biochem Pharmacol. 2023 Jul 26:115709. doi: 10.1016/j.bcp.2023.115709. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML) is characterized by impaired differentiation and indefinite proliferation of abnormal myeloid progenitors. Although differentiating agents were deemed to revolutionize AML therapy, most treated non-APL AML patients are refractory or relapse. According to cancer stem cell model, leukemia-initiating cells are the root cause of relapse given their unidirectional potential to generate differentiated AML blasts. Nonetheless, accumulating evidences emphasize the de-differentiation plasticity and leuke...
Source: Biochemical Pharmacology - July 28, 2023 Category: Drugs & Pharmacology Authors: Amal Kamal Abdel-Aziz Source Type: research
Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report
This report provides a synthesis of the key points discussed at the Town Hall and highlights needs and opportunities in ocular regenerative medicine.PMID:36978104 | DOI:10.1186/s13287-023-03282-y
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Ashley M Fortress Kiyoharu J Miyagishima Amberlynn A Reed Sally Temple Dennis O Clegg Budd A Tucker Timothy A Blenkinsop George Harb Thomas N Greenwell Tenneille E Ludwig Kapil Bharti Source Type: research
Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article
Biologics. 2023 Mar 20;17:33-40. doi: 10.2147/BTT.S401289. eCollection 2023.ABSTRACTEthiopia is attempting to reduce cancer-related morbidity and mortality through a strategic national cancer control plan but according to Globocan 2020, hematologic malignancies particularly leukemia and non-Hodgkin's lymphoma rank among the top five leading causes of new cancer incidence and cause of death among all age groups in both sexes. Hematopoietic stem-cell transplantation (HSCT) is an advanced treatment modality that makes the only effective treatment for cancer and non-cancer-related hematologic diseases unresponsive to conventio...
Source: Cancer Control - March 27, 2023 Category: Cancer & Oncology Authors: Sintayehu Mekonnen Hawi Farris Source Type: research
Lessons learned: a look back at the performance of nine COVID-19 serologic assays and their proposed utility
CONCLUSIONS: Our data suggests against the use of anti-SARS-CoV-2 assays to aid in acute diagnosis. RN TOT and RS TOT can readily identify past-resolved infection and vaccine response in the absence of native infection. We provide an estimate of expected antibody response in healthy VD over the time course of vaccination for which to compare antibody responses in immunosuppressed patients.PMID:36878344 | PMC:PMC9985916 | DOI:10.1016/j.clinbiochem.2023.03.003
Source: Clinical Biochemistry - March 6, 2023 Category: Biochemistry Authors: Nicole V Tolan Mia DeSimone Maria Fernandes Joshua E Lewis Daimon Simmons Peter Schur Manfred Brigl Milenko Tanasijevic Micha ël Desjardins Amy Sherman Lindsey Badenx Marion Snyder Stacy Melanson Source Type: research
A Short History of the Consideration of Sex Differences in Biomedical Research - Lessons for the < em > In Vitro < /em > Community from Animal Models and Human Clinical Trials
Altern Lab Anim. 2023 Feb 7:2611929231156720. doi: 10.1177/02611929231156720. Online ahead of print.ABSTRACTIn recent decades, it has become clear that in many fields - such as drug development, particularly with regard to drug dosage and specific disease treatment - the sex of a patient must be taken into consideration, in view of the fact that male and female physiology and pathophysiology show many differences of practical concern. While, in the last decade or so, considerable efforts have been undertaken to consider the sex of the animals during the planning of experiments, this topic has just started to be acknowledge...
Source: Alternatives to Laboratory Animals : ATLA - February 8, 2023 Category: Research Authors: Helena Niobe Renate Gutleb Arno Christian Gutleb Source Type: research
Lessons for the clinical nephrologist: lenalidomide-induced Fanconi syndrome in a patient with multiple myeloma post stem cell transplantation
J Nephrol. 2022 Sep 11. doi: 10.1007/s40620-022-01447-1. Online ahead of print.NO ABSTRACTPMID:36089632 | DOI:10.1007/s40620-022-01447-1
Source: Journal of Nephrology - September 11, 2022 Category: Urology & Nephrology Authors: Amit Kaushal Sri Harsha Boppana Jan Czyzyk Nattawat Klomjit Source Type: research
Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
CONCLUSIONS: Maturation strategies improve the metabolic characteristics of iPSC-CMs, but not to the level of the adult heart. Therefore, a combination of maturation strategies might prove to be more effective. Due to early onset hypertrophy, HCM iPSC-CMs may be less suitable to detect early disease modifiers in HCM and might prove more useful to examine the effects of gene editing and new drugs in advanced disease stages. With this review, we provide an overview of the assays used for characterization of cardiac metabolism in iPSC-CMs and advise on which metabolic assays to include in future maturation and disease modelin...
Source: Cell Research - July 23, 2022 Category: Cytology Authors: Sofija Vu čković Rafeeh Dinani Edgar E Nollet Diederik W D Kuster Jan Willem Buikema Riekelt H Houtkooper Miranda Nabben Jolanda van der Velden Birgit Goversen Source Type: research
Prediction of venous thromboembolism in patients with multiple myeloma treated with lenalidomide, bortezomib, dexamethasone, and transplantation: lessons from the substudy of IFM/DFCI 2009 cohort
CONCLUSIONS: Prospective studies are warranted in light of these results to improve VTE risk stratification and to design adapted thromboprophylaxis in terms of timing and dose.PMID:35557490 | DOI:10.1111/jth.15758
Source: Thrombosis and Haemostasis - May 13, 2022 Category: Hematology Authors: Emilie Chalayer Alexis Talbot Laurent Frenzel Lionel Karlin Philippe Collet Denis Guyotat Michel Attal Xavier Leleu Bernard Tardy Source Type: research
