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Total 838 results found since Jan 2013.

Intravenous Recombinant Tissue Plasminogen Activator and Ischemic Stroke: Focused Update of 2010 Clinical Practice Advisory From the American Academy of Emergency Medicine
Stroke treatment is a continuum that begins with the rapid identification of symptoms and treatment with transition to successful rehabilitation. Therapies for acute ischemic stroke (AIS) may vary based on anatomic location, interval from symptom onset, and coexisting health conditions. Successful therapy requires a seamless systematic approach with coordination from prehospital environment through acute management at medical facilities to disposition and long-term care of the patient. The emergency physician must balance the benefits and risks of alteplase recombinant tissue plasminogen activator (rtPA) for AIS management.
Source: The Journal of Emergency Medicine - March 12, 2018 Category: Emergency Medicine Authors: William J. Meurer, Bradley Barth, Michael Abraham, Jerome R. Hoffman, Gary M. Vilke, Gerard DeMers Tags: AAEM Clinical Practice Source Type: research

Elastic coupling power stroke mechanism of the F1-ATPase molecular motor Biochemistry
The angular velocity profile of the 120° F1-ATPase power stroke was resolved as a function of temperature from 16.3 to 44.6 °C using a ΔμATP = −31.25 kBT at a time resolution of 10 μs. Angular velocities during the first 60° of the power stroke (phase 1) varied inversely with...
Source: Proceedings of the National Academy of Sciences - May 29, 2018 Category: Science Authors: James L. Martin, Robert Ishmukhametov, David Spetzler, Tassilo Hornung, Wayne D. Frasch Tags: Biological Sciences Source Type: research

Comparison of best medical management with carotid intervention procedures in the prevention of stroke recurrence in patients with symptomatic internal carotid artery stenosis
Conclusions: Overall, there was no statistically significant difference in the rate of recurrence between the best medical management and the carotid interventional procedures.
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: BV Deepa Rani Sandeep Gampa Deepika Sirineni KR Harshavardhana Satya Rama Krishna Subhash Kaul Source Type: research

Full-dose thrombolysis for a right middle cerebral artery stroke after an acute aortic dissection
We report a case of a patient with an acute right middle cerebral artery stroke due to an acute aortic dissection (Stanford Type A) who was treated with full dose IV r-tpa resulting in a good outcome.
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: Syed Omar Kazmi Oliver Achi Rahul Damani Source Type: research

Hemorrhagic stroke and cerebral venous thrombosis: rare neurological sequelae of chickenpox infection
Anuradha Mehta, Aanchal Arora, Manoj Sharma, Rupali Malik, Yogesh Chandra PorwalAnnals of Indian Academy of Neurology 2018 21(3):228-232 Chickenpox (varicella) is primarily a disease of childhood which occurs due to infection with varicella-zoster virus (VZV). Primary VZV infection is rare in adults due to exposure in early childhood in our country. In adults, it is associated with some serious systemic and neurological complications which can follow both primary infection and reactivation of VZV. Neurological sequelae caused by primary VZV infection are rare and include encephalitis, aseptic meningitis, myelitis, acute c...
Source: Annals of Indian Academy of Neurology - September 4, 2018 Category: Neurology Authors: Anuradha Mehta Aanchal Arora Manoj Sharma Rupali Malik Yogesh Chandra Porwal Source Type: research

Stroke Transitions of Care.
Authors: Ross SY, Roberts S, Taggart H, Patronas C Abstract This quality improvement project focused on improving patient education and patient satisfaction, and reducing all-cause 30-day readmissions. A 72-hour discharge follow-up telephone call was completed in patients discharged home with diagnosis of stroke. PMID: 30304593 [PubMed]
Source: Medsurg Nursing : Official Journal of the Academy of Medical-Surgical Nurses - October 14, 2018 Category: Nursing Tags: Medsurg Nurs Source Type: research

The role of interventional neuroradiology in treatment of hemorrhagic stroke.
Abstract Treatment of hemorrhagic strokes necessitates hospitalization in an accommodated hospital offering the possibility of a multidisciplinary approach. In this setting, over recent years interventional radiology has become increasingly important from the diagnostic as well as the therapeutic standpoint. In the context of subarachnoid hemorrhage by intracranial aneurysm rupture, the NICE (National Institute for Health and Clinical Excellence) and ASA (American Stroke Academy) recommendations suggest that endovascular coiling should be considered as an alternative to surgical clipping (class I, level of evidenc...
Source: Presse Medicale - May 29, 2019 Category: General Medicine Authors: Michelozzi C, Cognard C Tags: Presse Med Source Type: research

Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke Neuroscience
Stroke is the leading cause of adult disability. Neurogenesis after stroke is associated with repair; however, the mechanisms regulating poststroke neurogenesis and its functional effect remain unclear. Here, we investigate multiple mechanistic routes of induced neurogenesis in the poststroke brain, using both a forelimb overuse manipulation that models a clinical...
Source: Proceedings of the National Academy of Sciences - July 1, 2019 Category: Science Authors: Huixuan Liang, Handi Zhao, Amy Gleichman, Michal Machnicki, Sagar Telang, Sydney Tang, Mary Rshtouni, Jack Ruddell, S. Thomas Carmichael Tags: PNAS Plus Source Type: research

Epidemiologic features, risk factors, and outcomes of respiratory infection in patients with acute stroke
Conclusions: Pneumonia seems to be a major complication in stroke patients. A better understanding of its risk factors is important for prevention and early recognition. Further studies are needed to clarify the optimal preventive treatment for SAP patients.
Source: Annals of Indian Academy of Neurology - October 24, 2019 Category: Neurology Authors: Lunlin Mao Xiaobo Liu Peng Zheng Saiping Wu Source Type: research

Metabolic Stroke: A Novel Presentation in a Child with Succinic Semialdehyde Dehydrogenase Deficiency
Sangeetha Yoganathan, Gautham Arunachal, Lisa Kratz, Mugil Varman, Maya Thomas, Sniya Valsa Sudhakar, Samuel Philip Oommen, Sumita DandaAnnals of Indian Academy of Neurology 2020 23(1):113-117 Succinic semialdehyde dehydrogenase (SSADH) deficiency is an autosomal recessive disorder of gamma-aminobutyric acid metabolism. Children with SSADH deficiency usually manifest with developmental delay, behavioral symptoms, language dysfunction, seizures, hypotonia, extrapyramidal symptoms, and ataxia. Diagnosis of SSADH deficiency is established by an abnormal urine organic acid pattern, including increased excretion of 4-hydroxybu...
Source: Annals of Indian Academy of Neurology - January 20, 2020 Category: Neurology Authors: Sangeetha Yoganathan Gautham Arunachal Lisa Kratz Mugil Varman Maya Thomas Sniya Valsa Sudhakar Samuel Philip Oommen Sumita Danda Source Type: research

Effect of age on arterial recanalization and clinical outcome in thrombolyzed acute ischemic stroke in CLOTBUST cohort
Conclusion: Elderly AIS patients achieve relatively poor functional outcome after IV-tPA despite similar rates of arterial recanalization. However, there is no increase in the hemorrhagic risk. Perhaps, decision for IV thrombolysis in elderly patients should be made cautiously.
Source: Annals of Indian Academy of Neurology - February 25, 2020 Category: Neurology Authors: Arvind Sharma Vijay K Sharma Aftab Ahmad Deepak Gupta Khursheed Khan Ashfaq Shuaib Andrei V Alexandrov Maher Saqqur Source Type: research

Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-inȷured rat brain regulates motor behavior Neuroscience
Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell–derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell–derived cortical neurons send widespread axonal projections to both hemispheres of rats...
Source: Proceedings of the National Academy of Sciences - April 20, 2020 Category: Science Authors: Sara Palma–Tortosa, Daniel Tornero, Marita Gronning Hansen, Emanuela Monni, Mazin Haȷy, Sopiko Kartsivadze, Sibel Aktay, Oleg Tsupykov, Malin Parmar, Karl Deisseroth, Galyna Skibo, Olle Lindvall, Zaal Kokaia Tags: Biological Sciences Source Type: research

Where are we now with aphasia after stroke ?
Pam Enderby, Laura SuttonAnnals of Indian Academy of Neurology 2020 23(8):57-62 Objective: To provide a brief review of research literature relating to the current state of knowledge regarding speech and language therapy for people with aphasia and place these research findings within the context of outcome data of non-selected patients receiving usual therapy in the UK. Methods: Part 1 presents a literature search aimed at exploring up-to-date information related to the nature and evolution of aphasia, the impact of therapy and the changing nature of therapy. This provides the context of what may be achieved in rehabilit...
Source: Annals of Indian Academy of Neurology - September 24, 2020 Category: Neurology Authors: Pam Enderby Laura Sutton Source Type: research

16834 Risk of hemorrhagic and ischemic stroke subsequent to diagnosis for hidradenitis suppurativa: Real-world data from a large urban Midwestern US patient population
Background: Although hidradenitis suppurativa (HS) has been reported to be associated with cardiovascular events, the risk for stroke has been inconsistently reported. The aim of this study is to determine the incidence of stroke in HS patients from real world data within a large urban midwestern US dermatology patient population.
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Jennifer Parker, Eran Gwillim, Yasmeen Ali, David Randall Pease, Anne E. Laumann, Dennis P. West, Beatrice Nardone Source Type: research