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Distribution of serotypes causing invasive pneumococcal disease in older adults from high-income countries and impact of pediatric and adult vaccination policies
CONCLUSIONS: Vaccinating older adults with higher-valency PCVs, especially PCV20, could substantially reduce the remaining IPD burden in high-income countries, regardless of current PCV use in pediatric NIPs and adult PPSV23 policies.PMID:37544825 | DOI:10.1016/j.vaccine.2023.08.001
Source: Vaccine - August 6, 2023 Category: Allergy & Immunology Authors: Lindsay R Grant Mary P E Slack Christian Theilacker Jelena Vojicic St éphane Dion Ralf-Rene Reinert Luis Jodar Bradford D Gessner Source Type: research

Addressing racial inequality and its effects on vaccination rate: A trial comparing a pharmacist and peer educational program (MOTIVATE) in diverse older adults
CONCLUSIONS: Both interventions significantly improved knowledge and trust toward vaccination and retained their effect 1 month after the program. The 2 effective community-based education models should be expanded to ensure timely and trusted information is available to educate older adults about vaccine-preventable diseases. Further research is encouraged to assess the long-term cost-effectiveness of these models' utilization on a larger scale. DISCLOSURES: Dr Schafer is an employee of Merck; however, at the time of the project, he was a professor at Thomas Jefferson University. The other authors have no conflicts of int...
Source: Herpes - July 31, 2023 Category: Infectious Diseases Authors: Katherine M Prioli Ayse Akincigil Tarlan Namvar Jocelyn Mitchell-Williams Jason J Schafer Renee C Cunningham Lynn Fields-Harris Megan McCoy Ronald Vertsman Ashley Guesnier Laura T Pizzi Source Type: research

Expert Review on Nonsurgical Management of Parapneumonic Effusion: Advances, Controversies, and New Directions
Semin Respir Crit Care Med. 2023 Aug;44(4):468-476. doi: 10.1055/s-0043-1769095. Epub 2023 Jul 10.ABSTRACTParapneumonic effusion and empyema are rising in incidence worldwide, particularly in association with comorbidities in an aging population. Also driving this change is the widespread uptake of pneumococcal vaccines, leading to the emergence of nonvaccine-type pneumococci and other bacteria. Early treatment with systemic antibiotics is essential but should be guided by local microbial guidelines and antimicrobial resistance patterns due to significant geographical variation. Thoracic ultrasound has emerged as a leading...
Source: Respiratory Care - July 10, 2023 Category: Respiratory Medicine Authors: Deirdre B Fitzgerald Eva Polverino Grant W Waterer Source Type: research

Pneumococcal Vaccination in Adults: What Can We Learn From Observational Studies That Evaluated PCV13 and PPV23 Effectiveness in the Same Population?
CONCLUSIONS: Overall, PCV13 demonstrated better protection than PPV23 against pneumococcal disease and all-cause respiratory outcomes in the included studies. Where evaluated, sequential PCV13/PPV23 vaccination showed little benefit over PCV13 alone. Results support the use of PCVs to protect against pneumococcal disease and respiratory infections in adults.PMID:36681604 | DOI:10.1016/j.arbres.2022.12.015
Source: Archivos de Bronconeumologia - January 21, 2023 Category: Respiratory Medicine Authors: Eileen M Dunne Catia Cilloniz Claire von Mollendorf Joseph Lewnard Lindsay R Grant Mary P E Slack Luis Jodar Christian Theilacker Bradford D Gessner Source Type: research

Adult Vaccination
Am Fam Physician. 2022 Nov;106(5):534-542.ABSTRACTAdult vaccination rates are low in the United States, despite clear benefits for reducing morbidity and mortality. Vaccine science is evolving rapidly, and family physicians must maintain familiarity with the most recent guidelines. The recommended adult immunization schedule is updated annually by the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention. All eligible patients should receive SARS-CoV-2 vaccines according to the current guidelines. Adults without contraindications should also receive an annual influenza vaccine. Hepa...
Source: Herpes - November 15, 2022 Category: Infectious Diseases Authors: Grant M Greenberg Princy A Koshy Mary Jane S Hanson Source Type: research

Attendance and vaccination at immunization clinics in rural Gambia before and during the COVID-19 pandemic
CONCLUSION: The reduced EPI attendance during the pandemic interruption period lasted only 3 months. Significant recovery in EPI attendance occurred during the late recovery period, while rates of monthly immunization returned to pre-pandemic levels for most antigens. EPI programmes should implement strategies to deliver missed antigens when infants do present to EPI clinics, aware that missed doses may be age dependent.PMID:36180374 | PMC:PMC9468317 | DOI:10.1016/j.vaccine.2022.09.031
Source: Vaccine - September 30, 2022 Category: Allergy & Immunology Authors: Isaac Osei Golam Sarwar Ilias Hossain Kemo Sonko Lamin Ceesay Bubacarr Baldeh Ebba Secka Grant A Mackenzie Source Type: research

Burden of pneumococcal disease due to serotypes covered by the 13-valent and new higher-valent pneumococcal conjugate vaccines in the United States
Vaccine. 2022 Jun 23:S0264-410X(22)00773-3. doi: 10.1016/j.vaccine.2022.06.024. Online ahead of print.ABSTRACTThe addition of pneumococcal conjugate vaccines (PCVs) to the United States (US) national immunization program led to significant reductions in incidence, mortality, and associated sequelae caused by pneumococcal disease (PD) in children and adults through direct and indirect protection. However, there remains clinical and economic burden due to PD caused by serotypes not included in the current 13-valent PCV (PCV13) formulation. To address this unmet need, 15-valent PCV (PCV15) and 20-valent PCV (PCV20), containin...
Source: Vaccine - June 26, 2022 Category: Allergy & Immunology Authors: Liping Huang Matt Wasserman Lindsay Grant Raymond Farkouh Vincenza Snow Adriano Arguedas Erica Chilson Reiko Sato Johnna Perdrizet Source Type: research

Proteomic Analysis and Virulence Assessment of Granulicatella adiacens Secretome
In conclusion, we unraveled the secretome of G. adiacens, an oral bacterium well-documented in infective endocarditis, but also recently shown to be involved in oral infections. Importantly, the secretome of G. adiacens comprised of a large number of putative virulence factors. Of particular importance is the finding that the G. adiacens secretome comprised of a number of “moonlighting” proteins, which in other species are shown to enhance bacterial colonization and virulence through their multifunctional roles (Pavkova et al., 2017; Graf et al., 2019). Thus, our results provide a basis for investigating th...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research

Is Bill Gates a Humanitarian, Villain or Misguided Man?
Conclusion The Bill and Melinda Gates Foundation has donated money to 100 countries and the United States with their stated objective to improve education and world health. Investor Warren Buffet is a primary contributor to the foundation. Some of the foundation’s programs target schools, farmers, and sanitation needs, all worthy causes. One of their primary programs, with significant funding, has included vaccination programs focused on developing countries. These vaccine initiatives have resulted in documented deaths and injuries for thousands of previously healthy children. Are Melinda and Bill Gates simply misguided ...
Source: vactruth.com - July 16, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Top Stories Bill and Melinda Gates Foundation truth about vaccines Vaccine Death Source Type: blogs

How Aggressive are Your Student’s College Vaccination Policies?
Conclusion College campuses vary in regards to their vaccine policies.  The meningitis vaccine is the most commonly required vaccination for all incoming freshmen, based on the recommendations of the CDC. Several other vaccinations are required and recommended, with much variation by individual colleges. Most universities provide a religious exemption for students, but some do not. It is worthwhile to investigate what your university vaccine policies are, in addition to the exemptions that exist for colleges in which your student has an interest. Learn More to Make Your Own Informed Vaccination Choices For additional re...
Source: vactruth.com - September 3, 2015 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Top Stories Top Picks Michelle Goldstein Logical Meningitis Mandatory Vaccination U.S. Centers for Disease Control and Prevention meningococcal disease Vaccine Exemption Vaccine Adverse Events Reporting System (VAERS) University of Was Source Type: blogs