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Leptin enhances hepatic fibrosis and inflammation in a mouse model of cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions such as cholestasis is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody (Leptin-Ab) on biliary hyperplasia, hepatic fibrosis and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed...
Source: Am J Pathol - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research

Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions, such as cholestasis, is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody on biliary hyperplasia, hepatic fibrosis, and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed by quant...
Source: The American Journal of Pathology - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research

Viruses, Vol. 14, Pages 1673: Detection of HIV-1 Transmission Clusters from Dried Blood Spots within a Universal Test-and-Treat Trial in East Africa
vlir Andrew Leigh Brown The Sustainable East Africa Research in Community Health (SEARCH) trial was a universal test-and-treat (UTT) trial in rural Uganda and Kenya, aiming to lower regional HIV-1 incidence. Here, we quantify breakthrough HIV-1 transmissions occurring during the trial from population-based, dried blood spot samples. Between 2013 and 2017, we obtained 549 gag and 488 pol HIV-1 consensus sequences from 745 participants: 469 participants infected prior to trial commencement and 276 SEARCH-incident infections. Putative transmission clusters, with a 1.5% pairwise genetic distance threshold, were inferred ...
Source: Viruses - July 29, 2022 Category: Virology Authors: Emma Pujol-Hodge Jesus Salazar-Gonzalez Deogratius Ssemwanga Edwin Charlebois James Ayieko Heather Grant Teri Liegler Katherine Atkins Pontiano Kaleebu Moses Kamya Maya Petersen Diane Havlir Andrew Leigh Brown Tags: Article Source Type: research

Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment
CONCLUSIONS: The evidence from randomised controlled trials concerning the effectiveness of non-surgical interventions to accelerate orthodontic treatment is of low to very low certainty. It suggests that there is no additional benefit of light vibrational forces or photobiomodulation for reducing the duration of orthodontic treatment. Although there may be a limited benefit from photobiomodulation application for accelerating discrete treatment phases, these results have to be interpreted with caution due to their questionable clinical significance. Further well-designed, rigorous RCTs with longer follow-up periods spanni...
Source: Cochrane Database of Systematic Reviews - June 20, 2023 Category: General Medicine Authors: Ahmed El-Angbawi Grant McIntyre Padhraig S Fleming David Bearn Source Type: research

Memex
Funding Opportunity Number: DARPA-BAA-14-21 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementOtherProcurement ContractCategory of Funding Activity: Science and Technology and other Research and DevelopmentCFDA Number: 12.910Eligible Applicants Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Agency Name: DOD-DARPA-I2OClosing Date: Apr 08, 2014Award Ceiling: Expected Number of Awards: Creation Date: Feb 04, 2014Funding Opportunity Description: The Defense Advanced Research Projects...
Source: Grants.gov - February 12, 2014 Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

Systems Science
Funding Opportunity Number: PD-14-8085 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: Science and Technology and other Research and DevelopmentCFDA Number: 47.041Eligible Applicants Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Agency Name: NSFClosing Date: Feb 17, 2015Award Ceiling: Expected Number of Awards: 15Creation Date: Oct 21, 2014Funding Opportunity Description: The Systems Science (SYS) program supports fundamental research leading to a theoretical fou...
Source: Grants.gov - October 22, 2014 Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

Funding Databases
When considering applying for a funding opportunity it is often helpful to know what types of projects that have been funded in the past. Every RML in the NNLM includes listings of the Past Funded Projects on their website for this reason. But did you know that you can also find this information for NIH, HHS, and all of the US government? These databases can be particularly helpful for postdoctoral students, junior faculty, and anyone who is beginning to search for external funding. The NIH RePORTER database allows the user to search for funded grants throughout all of NIH. One interesting feature is the Matchmaker functio...
Source: Network News - March 15, 2017 Category: Databases & Libraries Authors: NN/LM South Central Region Tags: Grants and Funding Research Source Type: news

When Police Misread Tea Leaves They Violate the Fourth Amendment
Police militarization and excessive force have become increasingly pressing issues in American society. Fortunately, the Denver-based U.S. Court of Appeals for the Tenth Circuit – Justice Neil Gorsuch’s old stomping ground –held yesterday that innocent victims of improper police procedures during dynamic drug raids have some protections. Even if the court didn ’t fully address the issues Cato raised inour brief, the ruling inHarte v. Board of Commissioners of Johnson County, Kansasis a step forward.In 2011, Robert Harte and his two children visited a garden store to buy tomatoes for his 13-year old son ’s school ...
Source: Cato-at-liberty - July 26, 2017 Category: American Health Authors: Ilya Shapiro Source Type: blogs