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Total 152 results found since Jan 2013.

2023 Vascular Research Initiatives Conference: Structural and Immune Cells in Vascular Disease
JVS Vasc Sci. 2023 Jul 10;4:100117. doi: 10.1016/j.jvssci.2023.100117. eCollection 2023.ABSTRACTThe 2023 Vascular Research Initiatives Conference (VRIC) was held in Boston, Massachusetts, and coincided with the first day of Vascular Discovery 2023, hosted by the American Heart Association. VRIC attracts vascular clinicians, surgeon-scientists, and basic science researchers to a common arena to facilitate the exchange of basic and translational science to stimulate and inspire participants to study and find solutions to vascular conditions. The theme of the conference this year was "Structural and Immune Cells in Vascular D...
Source: Atherosclerosis - August 31, 2023 Category: Cardiology Authors: Carly Thaxton Katherine Gallagher Alan Dardik Source Type: research

Higher cyclophosphamide dose grants optimal stem-cell collection after daratumumab-based induction in multiple myeloma
Haematologica. 2023 Jul 13. doi: 10.3324/haematol.2023.283452. Online ahead of print.ABSTRACTNot available.PMID:37439346 | DOI:10.3324/haematol.2023.283452
Source: Haematologica - July 13, 2023 Category: Hematology Authors: Carmine Liberatore Tommaso Perini Cecilia Passeri Valeria Ferla Francesca Fioritoni Virginia Girlando Ornella Iuliani Alessia Orsini Guido Montanaro Francesca Farina Alessandro Di Nicola Rosamaria Nitti Stefano Pulini Sara Mastaglio Stella Santarone Milen Source Type: research

H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function
Nat Struct Mol Biol. 2023 Jun 12. doi: 10.1038/s41594-023-01016-5. Online ahead of print.ABSTRACTMammalian genomes harbor abundant transposable elements (TEs) and their remnants, with numerous epigenetic repression mechanisms enacted to silence TE transcription. However, TEs are upregulated during early development, neuronal lineage, and cancers, although the epigenetic factors contributing to the transcription of TEs have yet to be fully elucidated. Here, we demonstrate that the male-specific lethal (MSL)-complex-mediated histone H4 acetylation at lysine 16 (H4K16ac) is enriched at TEs in human embryonic stem cells (hESCs...
Source: Mol Biol Cell - June 12, 2023 Category: Molecular Biology Authors: Debosree Pal Manthan Patel Fanny Boulet Jayakumar Sundarraj Olivia A Grant Miguel R Branco Srinjan Basu Silvia D M Santos Nicolae Radu Zabet Paola Scaffidi Madapura M Pradeepa Source Type: research

Scientists use AI to identify likely drug targets in search for Alzheimer ' s cure
Scientists use AI to identify likely drug targets in search for Alzheimer's cure A team led by a University of Arizona College of Medicine – Tucson scientist harnesses artificial intelligence to trace the path from a healthy brain cell to one afflicted by Alzheimer ' s disease. Anna C. Christensen Today College of Medicine – TucsonRui-Chang_khp-web.jpg Rui Chang, an associate professor of neurology, is leading a team at the College of Medicine – Tucson that uses artificial intelligence to trace the molecular path of the development of Alzheimer's disease.HealthCollege of Medicine - TucsonDeterminationE...
Source: The University of Arizona: Health - May 15, 2023 Category: Universities & Medical Training Authors: mittank Source Type: research

ISAnalytics enables longitudinal and high-throughput clonal tracking studies in hematopoietic stem cell gene therapy applications
Brief Bioinform. 2022 Dec 21:bbac551. doi: 10.1093/bib/bbac551. Online ahead of print.ABSTRACTLongitudinal clonal tracking studies based on high-throughput sequencing technologies supported safety and long-term efficacy and unraveled hematopoietic reconstitution in many gene therapy applications with unprecedented resolution. However, monitoring patients over a decade-long follow-up entails a constant increase of large data volume with the emergence of critical computational challenges, unfortunately not addressed by currently available tools. Here we present ISAnalytics, a new R package for comprehensive and high-throughp...
Source: Briefings in Bioinformatics - December 22, 2022 Category: Bioinformatics Authors: Giulia Pais Giulio Spinozzi Daniela Cesana Fabrizio Benedicenti Alessandra Albertini Maria Ester Bernardo Bernhard Gentner Eugenio Montini Andrea Calabria Source Type: research

Multinuclear MRI Reveals Early Efficacy of Stem Cell Therapy in Stroke
Transl Stroke Res. 2022 Jul 28. doi: 10.1007/s12975-022-01057-w. Online ahead of print.ABSTRACTCompromised adult human mesenchymal stem cells (hMSC) can impair cell therapy efficacy and further reverse ischemic recovery. However, in vitro assays require extended passage to characterize cells, limiting rapid assessment for therapeutic potency. Multinuclear magnetic resonance imaging and spectroscopy (MRI/S) provides near real-time feedback on disease progression and tissue recovery. Applied to ischemic stroke, 23Na MRI evaluates treatment efficacy within 24 h after middle cerebral artery occlusion, showing recovery of sodiu...
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Shannon Helsper Xuegang Yuan F Andrew Bagdasarian Jacob Athey Yan Li Cesario V Borlongan Samuel C Grant Source Type: research

Erratum to: Human umbilical cord mesenchymal stem cell-derived mitochondria (PN-101) attenuate LPS-induced inflammatory responses by inhibiting NF κB signaling pathway
BMB Rep. 2022 Jul;55(7):361.ABSTRACT[Erratum to: BMB Reports 2022; 55(3): 136-141, PMID: 34488927, PMCID: PMC8972135] The BMB Reports would like to correct in BMB Rep. 55(3):136-141, titled "Human umbilical cord mesenchymal stem cell-derived mitochondria (PN-101) attenuate LPS-induced inflammatory responses by inhibiting NFκB signaling pathway". This research was supported by NRF-2016R1A2B4007640 grant (to C-H Kim). Since grant number is incorrect, this information has now been corrected as follows: We would like to thank various Paean Biotechnology Inc. members who participated in the project. This work was supported by ...
Source: BMB Reports - July 27, 2022 Category: Biochemistry Authors: Shin-Hye Yu Soomin Kim Yujin Kim Seo-Eun Lee Jong Hyeok Park Gayoung Cho Jong-Cheon Ha Hahnsun Jung Sang-Min Lim Kyuboem Han Hong Kyu Lee Young Cheol Kang Chun-Hyung Kim Source Type: research