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What Causes Irritability?
Discussion Child abuse or non-accidental trauma is a clinical diagnosis. It is the constellation of history, physical examination, radiographic evaluation, laboratory testing and investigation that determines if child abuse has occurred. Irritability caused by fractures or other trauma can be a presenting symptom of abuse. Fractures can be a presentation but they are also common problems not associated with abuse. Femoral shaft fractures are estimated to account for only 1.6% of all fractures in children, therefore they are potentially more suspicious for child abuse. A review of femur fractures can be found here. A review...
Source: PediatricEducation.org - October 18, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Conference on Drug Pricing Inject New Statistics Into Debate, Few New Insights (Part 2 of 2)
The first part of this article described the upward pressures on costs and some of the philosophical debates over remedies. This section continues the discussion with several different angles on costs. Universal access and innovation It’s easy to call health care a human right. But consider an analogy: housing could also be considered a human right, yet no one has the right to a twenty-room mansion. Modern drug and genetic research are creating the equivalents of many twenty-room mansions, and taking up residence means the difference between life and death for someone, or perhaps between a long productive life and on...
Source: EMR and HIPAA - November 9, 2018 Category: Information Technology Authors: Andy Oram Tags: Healthcare Reform Medical Economics Personalized Medicine Precision Medicine Drug Pricing Healthcare Costs Medication Pricing Source Type: blogs

Tropical Travel Trouble 010 Fever, Arthralgia and Rash
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 010 Peer Reviewer: Dr Jennifer Ho, ID physician QLD, Australia You are an ED doc working in Perth over schoolies week. An 18 yo man comes into ED complaining of fever, rash a “cracking headache” and body aches. He has just hopped off the plane from Bali where he spent the last 2 weeks partying, boozing and running amok. He got bitten by “loads” of mosquitoes because he forgot to take insect repellent. On examination he looks miserable,...
Source: Life in the Fast Lane - July 16, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine arthralgia dengue fever rash Source Type: blogs

Tropical Travel Trouble 009 Humongous HIV Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low ...
Source: Life in the Fast Lane - July 7, 2018 Category: Emergency Medicine Authors: Amanda McConnell Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs

Old meningitis B vaccine 'may also protect against gonorrhoea'
Conclusion This large study found an association between having the MeNZB vaccine and a reduced likelihood of being diagnosed with gonorrhoea. But it's difficult to form any firm conclusions because of the nature of the case and control groups. For example, given that both groups were sexually active, we don't know why the majority of people with gonorrhoea didn't also have a chlamydia infection, and how this may have affected the results. It could just be down to pure chance and have nothing to do with the vaccine. So before we celebrate the alleged "cure of gonorrhoea", there are many things to consider: T...
Source: NHS News Feed - July 11, 2017 Category: Consumer Health News Tags: Medication Source Type: news

A 7-Pound Premature Baby Died After Receiving 8 Vaccine Doses, Her Death Was Blamed On Co-Sleeping Instead Of The Toxic Vaccines
Conclusion Medical examiners are putting the blame on parents for co-sleeping, while completely ignoring the vaccines given to the child hours or days before, when investigating these infant deaths. They will also relate an infant’s death to poisoning of the body due to something the child ingested or inhaled, but not from the poisons injected through the vaccines. [29] In the state of Louisiana, health officials have been applauded for having fairly high vaccination rates, but at the same time, Louisiana has consistently been ranked one of the worst states in the nation for having high infant mortality rates, but nowher...
Source: vactruth.com - January 19, 2017 Category: Allergy & Immunology Authors: Augustina Ursino Tags: Augustina Ursino Case Reports on Vaccine Injury Human Recent Articles Top Picks Top Stories Aysia Hope Clark Lafayette General Medical Center National Vaccine Injury Compensation Program Recombivax Source Type: blogs

How to Protect Yourself if You are Force-Vaccinated
Conclusions Avoiding vaccines is the best line of defense against exposure to dangerous toxins. If one is faced with the necessity to vaccinate, there are several important health measures which may reduce damage. Not vaccinating when ill, and spreading out vaccinations as much as possible can reduce likelihood of vaccine damage. Use of a cold pack immediately following vaccination can help block an immune reaction. Use of vitamin C before and after vaccination is considered critical. Deciding on a protocol inclusive of several antioxidants including vitamins D3 and E is important. Smoothies made with celery and parsley an...
Source: vactruth.com - August 27, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Recent Articles Top Stories Dr. Blaylock force vaccinated Mandatory Vaccination Neil Miller truth about vaccines Source Type: blogs



Infant Paralyzed and Brain-Damaged After 6-Month Vaccinations, Doctors Threatened Parents to Further Vaccinate Their Daughter
Conclusion There are many legitimate reasons why parents don’t want their child subjected to what is in any vaccine. We are outraged at the disregard for Cerenity’s life and what her family is going through. In a situation such as what happened to Cerenity, it is absurd doctors would blatantly ignore Cerenity’s vaccine reactions and tell her parents to continue vaccinating her. We hope Cerenity will get the necessary treatment to heal from these vaccine-related injuries. If you have experienced a similar situation and have helpful advice to offer, please reach out to VacTruth, to get in touch with Cerenity’s mother...
Source: vactruth.com - April 2, 2016 Category: Allergy & Immunology Authors: Augustina Ursino Tags: Augustina Ursino Human Top Stories adverse reactions Cerenity Escamilla chiari malformation hypertonic dystonia infant paralysis transverse myelitis truth about vaccines vaccine injury Source Type: blogs

Volume: 26 Issue: 6
Michel G Bergeron ?MGB? ? a true success Digging for new solutions Invasive disease due to Haemophilus influenzae type A in children in Canada?s north: A priority for prevention. Letter to the Editor: Treatment outcomes with telaprevir-based therapy for HIV/hepatitis C coinfected patients are comparable with hepatitis C monoinfected patients An unusual case of abdominal pain Characterization of invasive Neisseria meningitidis from Atlantic Canada, 2009 to 2013: With special reference to the nonpolysaccharide vaccine targets (PorA, factor H binding protein, Neisseria heparin-binding antigen and Neisseria adhesin A)<span ...
Source: Canadian Journal of Infectious Diseases and Medical Microbiology - December 23, 2015 Category: Infectious Diseases Source Type: research

Why Target Vaccines?
Anti-vaccination campaigners have reached the forefront of the news. When a public health issue has reached the Jimmy Kimmel show, you know that it has reached the "big time." Seth Mnookin wrote the book The Panic Virus: The True Story of the Vaccine-Autism Controversy. Both Kimmel and Mnookin mentioned Jenny McCarthy, who has been quite vocal about her concerns about vaccines. More measles outbreaks have occurred in the past year than in the past decade, with the majority occurring among unvaccinated children. Buzzfeed asked vaccine expert Kate O'Brien of the International Vaccine Access Center (IVAC) at the Johns Hopkins...
Source: Healthy Living - The Huffington Post - April 8, 2015 Category: Consumer Health News Source Type: news

Improving the care of children and young people in the UK: 20 years on
Introduction In 2000, practitioners in child health asked a simple question—who speaks for children and their health at the policy level?1 It documented the invisibility of children in the National Health Service (NHS) and made recommendations for the future. As we experience unprecedented political turbulence, austerity, increasing poverty and ideological reforms of health and education, is all well in the UK for children, childhood and child health now? The context Children are our nation's most precious resource because of the change in the old age dependency ratio—the number of active working age adults per...
Source: Archives of Disease in Childhood - December 15, 2014 Category: Pediatrics Authors: Aynsley-Green, A. Tags: Immunology (including allergy), Meningitis, TB and other respiratory infections, Tropical medicine (infectious diseases), Vaccination / immunisation, Infection (neurology), Neuromuscular disease, Pain (neurology), Adolescent health, Child health, Pain (pa Source Type: research

Acceptability of immunization in adult contacts of infants: Possibility of expanding platforms to increase adult vaccine uptake.
CONCLUSIONS: Most adults were willing to be vaccinated if offered during hospital visits or clinic appointments for mother or infant. Development and expansion of recommended immunization platforms, such as the cocooning platform, offers the opportunity to increase adult vaccination coverage. PMID: 24681227 [PubMed - as supplied by publisher]
Source: Vaccine - March 26, 2014 Category: Allergy & Immunology Authors: Beel ER, Rench MA, Montesinos DP, Healy CM Tags: Vaccine Source Type: research