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Effects of a Pharmacist-Led Educational Interventional Program on Electronic Monitoring-Assessed Adherence to Direct Oral Anticoagulants: A Randomized, Controlled Trial in Patients with Nonvalvular Atrial Fibrillation
In this study, the selection of DOACs was not randomized, and the lack of assessment of the association between adherence to DOACs and clinical outcomes was a limitation. Japan Registry of Clinical Trials (jRCT) indentifier: jRCTs031180142. (Clin Ther. 2022;44:XXX-XXX) © 2022 Elsevier Inc.PMID:36244853 | DOI:10.1016/j.clinthera.2022.09.011
Source: Clinical Therapeutics - October 16, 2022 Category: Drugs & Pharmacology Authors: Tsuyoshi Shiga Toshimi Kimura Noritoshi Fukushima Yuji Yoshiyama Kazunori Iwade Fumiaki Mori Yoichi Ajiro Shoji Haruta Yuichiro Yamada Emi Sawada Nobuhisa Hagiwara SMAAP-AF Investigators Source Type: research

Eating your 5 A DAY 'could make you more optimistic'
Conclusion This is well-conducted research which has used a validated measure to assess the optimism of a sample of middle-aged American citizens and measure their blood antioxidant levels. The researchers found a link between higher carotenoid levels and higher optimism, but as the researchers rightly conclude, their findings do not prove cause and effect and it isn’t possible to say in which direction the relationship is going. It is possible that having higher levels of antioxidants in the body leads to better physical health and this in turn enhances optimism, but then it is equally possible that people who are in be...
Source: NHS News Feed - January 18, 2013 Category: Consumer Health News Tags: Food/diet Mental health Source Type: news

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin.
CONCLUSIONSMetformin use was associated with impaired cognitive performance. Vitamin B12 and calcium supplements may alleviate metformin-induced vitamin B12 deficiency and were associated with better cognitive outcomes. Prospective trials are warranted to assess the beneficial effects of vitamin B12 and calcium use on cognition in older people with diabetes who are taking metformin. PMID: 24009301 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 5, 2013 Category: Endocrinology Authors: Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H, Woodward M, Boundy K, Ellis KA, Bush AI, Faux NG, Martins R, Szoeke C, Rowe C, Watters DA, the AIBL Investigators Tags: Diabetes Care Source Type: research

In women, increased dietary antioxidants are associated with reduced risk of developing heart failure
Commentary on Rautiainen S, Levitan EB, Mittleman MA, et al.. Total antioxidant capacity of diet and risk of heart failure: a population-based prospective cohort of women. Am J Med 2013;126:494–500. Implications for practice and research A diet rich in natural antioxidants may reduce the risk of developing heart failure. Well-designed intervention studies are needed to investigate the effect of a diet rich in antioxidants on heart failure incidence. Context Heart failure is a syndrome comprising symptoms such as breathlessness alongside objective evidence of cardiac dysfunction. This is a common condition with a cons...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Authors: McKeown, P., McKeag, N. Tags: Drugs: cardiovascular system, Heart failure, Stroke, Diet, Vitamins and supplements, Ischaemic heart disease, Diabetes, Medical humanities, Alcohol, Health education, Smoking, Health effects of tobacco use, Tobacco use Women ' s health Source Type: research

Appropriateness of Prescribing Dabigatran Etexilate and Rivaroxaban in Patients With Nonvalvular Atrial Fibrillation: A Prospective Study.
CONCLUSIONS:: Inappropriate use of DE and rivaroxaban in patients with NVAF is frequent and possibly leads to AEs. Reinforcing education of health care professionals and patients is needed. Collaboration with clinical pharmacists can contribute to better use. PMID: 24982310 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - June 30, 2014 Category: Drugs & Pharmacology Authors: Larock AS, Mullier F, Sennesael AL, Douxfils J, Devalet B, Chatelain C, Dogné JM, Spinewine A Tags: Ann Pharmacother Source Type: research

Nutrient biomarkers and vascular risk factors in subtypes of mild cognitive impairment: A cross-sectional study
Conclusions Several nutrient biomarkers in MCI patients, especially in md-MCI patients, were lower compared with healthy controls, suggesting that lower 25OHD and DHA levels are risk factors for MCI. However, we found no evidence that FSRP is an early biomarker of MCI.
Source: The Journal of Nutrition, Health and Aging - September 23, 2014 Category: Nutrition Source Type: research

Pros and cons of new oral anticoagulants.
Authors: Bauer KA Abstract The availability of new oral anticoagulants (NOACs) targeting either thrombin (dabigatran etexilate) or factor Xa (rivaroxaban and apixaban) for the prevention and treatment of thrombosis has been highly anticipated. NOACs have major pharmacologic advantages over vitamin K antagonists (eg, warfarin), including rapid onset/offset of action, few drug interactions, and predictable pharmacokinetics, eliminating the requirement for regular coagulation monitoring. Regulatory agencies have approved several NOACs for specific indications based on the results of clinical trials demonstrating effic...
Source: Hematology ASH Education Program - November 11, 2014 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

The Double Burden of Malnutrition
These Haitian schoolchildren are being supported by a WFP school feeding programme designed to end malnutrition which, for many countries, can be a double burden where overweight and obesity exist side by side with under-nutrition. Credit: UN Photo/Albert González FarranBy Gloria SchiaviROME, Nov 23 2014 (IPS)Not only do 805 million people go to bed hungry every day, with one-third of global food production (1.3 billion tons each year) being wasted, there is another scenario that reflects the nutrition paradox even more starkly: two billion people are affected by micronutrients deficiencies while 500 million individuals s...
Source: IPS Inter Press Service - Health - November 23, 2014 Category: Global & Universal Authors: Gloria Schiavi Tags: Development & Aid Featured Food & Agriculture Global Headlines Health Human Rights IPS UN: Inside the Glasshouse Population Poverty & MDGs Women & Economy breastfeeding Children Civil Society disease family farming FAO Fr Source Type: news

OPINION: Now Is the Time to Tackle Malnutrition and Its Massive Human Costs
Sadhana Ghimire, 23, makes sure to give her 18-month-old daughter nutritious food, such as porridge containing grains and pulses, in order to prevent stunting. Credit: Mallika Aryal/IPSBy José Graziano da Silva and Margaret ChanROME/GENEVA, Nov 13 2014 (IPS)The scourge of malnutrition affects the most vulnerable in society, and it hurts most in the earliest stages of life. Today, more than 800 million people are chronically hungry, about 11 percent of the global population.Undernutrition is the underlying cause of almost half of all child deaths, and a quarter of living children are stunted due to inadequate nutrition. Mi...
Source: IPS Inter Press Service - Health - November 13, 2014 Category: Global & Universal Authors: Jose Graziano da Silva and Margaret Chan Tags: Advancing Deserts Biodiversity Climate Change Development & Aid Economy & Trade Environment Food & Agriculture Global Global Governance Headlines Health IPS UN: Inside the Glasshouse Population Poverty & MDGs TerraViva United N Source Type: news

Implementation of non-vitamin K antagonist oral anticoagulants in daily practice: the need for comprehensive education for professionals and patients
Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly used for the prevention and treatment of venous thromboembolism and for stroke prevention in patients with atrial fibrillation. NOACs do not require routine coagulation monitoring, creating a challenge to established systems for patient follow-up based on regular blood tests. Healthcare professionals (HCPs) are required to cope with a mixture of patients receiving either a vitamin K antagonist or a NOAC for the same indications, and both professionals and patients require education about the newer drugs. A European working group convened to consider the ...
Source: Thrombosis Journal - May 26, 2015 Category: Hematology Authors: Hein HeidbuchelDana BertiManuel CamposLien DestegheAna FreixoAntónio NunesVanessa RoldánVincenzo ToschiRiitta Lassila Source Type: research

Half a handful of nuts a day 'reduces early death risk'
Conclusion This Dutch cohort of middle-aged to elderly adults generally found people were less likely to die in the following 10 years if they ate a small number of nuts a day compared with none. The study has strengths in its large sample size and that cause of death was followed up for the full cohort using valid medical codes. However, there are various points to bear in mind before we jump to the conclusion that nuts are the magic ingredient that will slash our risk of death. No clear trends It is difficult to draw any clear interpretations about how nut consumption may be associated with risk of death overall or fr...
Source: NHS News Feed - June 12, 2015 Category: Consumer Health News Tags: Food/diet Cancer Heart/lungs Diabetes Source Type: news

Health News: Believe it or Not
Vitamin D Deficiency May Cause MS Employees Working Long Hours Face Increased Risk of Stroke Coffee Could Literally be a Lifesaver When you see these health headlines do you immediately think of how it pertains to you or someone you know?  You probably don’t think, “I should make sure this information is from a reputable source,” or “I should read that research article that this information is based on and ask my clinician about it.” Health care reporting is complicated and has its challenges.  Many journalists do not have the background or education in health and science and are just as uni...
Source: Dragonfly - December 11, 2015 Category: Databases & Libraries Authors: Carolyn Martin Tags: Health Literacy/Consumer Health Source Type: news

Our Global Food Challenges: The Decade to Act
This article was originally published with the Medical Journal of Australia. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - April 11, 2016 Category: Consumer Health News Source Type: news

Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation
Conclusion</div>The results of AXAFA-AFNET 5 will provide evidence informing about the safety of apixaban in ablation patients and on its efficacy including effects on silent brain lesions. AXAFA – AFNET 5 is an investigator-initiated trial sponsored by AFNET. The trial is supported by the DZHK (German Centre for Cardiovascular Research) and by the BMBF (German Ministry of Education and Research) and by Bristol-Myers Squibb/Pfizer Alliance.</span>
Source: Europace - October 13, 2016 Category: Cardiology Source Type: research

Real-life experience with the specific reversal agent idarucizumab for the management of emergency situations in dabigatran-treated patients: a series of 11 cases
We report 11 real-life clinical cases in which idarucizumab was used after multidisciplinary consultation in a variety of emergency situations including severe postoperative bleeding, emergency high-bleeding-risk surgery (hip/spine surgery and neurosurgery), invasive diagnostic testing (lumbar puncture), intracranial bleeding (pre-pontine subarachnoid hemorrhage and lobar intracerebral hemorrhage) and thrombolysis with recombinant tissue plasminogen activator for acute ischemic stroke. This case series illustrates the role of idarucizumab in improving patient safety in rare emergency situations requiring rapid reversal of ...
Source: Journal of Thrombosis and Thrombolysis - February 15, 2017 Category: Hematology Source Type: research

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