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Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Understanding common population markers for SARS-CoV-2 RNA normalization in wastewater - A review
Chemosphere. 2023 May 16;333:138682. doi: 10.1016/j.chemosphere.2023.138682. Online ahead of print.ABSTRACTWastewater monitoring and epidemiology have seen renewed interest during the recent COVID-19 pandemic. As a result, there is an increasing need to normalize wastewater-derived viral loads in local populations. Chemical tracers, both exogenous and endogenous compounds, have proven to be more stable and reliable for normalization than biological indicators. However, differing instrumentation and extraction methods can make it difficult to compare results. This review examines current extraction and quantification method...
Source: Chemosphere - May 18, 2023 Category: Chemistry Authors: Femi F Oloye Yuwei Xie Jonathan K Challis Oluwabunmi P Femi-Oloye Markus Brinkmann Kerry N McPhedran Paul D Jones Mark R Servos John P Giesy Source Type: research

E-Cigarette Vapour Increases ACE2 and TMPRSS2 Expression in a Flavour- and Nicotine-Dependent Manner
In this study, healthy donor bronchial epithelial cells (NHBE) and monocyte-derived macrophages (MDM) were exposed to cigarette smoke extract (CSE) or nicotine or flavoured E-cigarette vapour extract (EVE) before the assessment of SARS-CoV-2 recognition receptors ACE2 and TMPRSS2 genes. MDMs exposed to CSE and Tobacco EVE showed increased ACE2 expression; however, no treatment altered the TMPRSS2 expression. ACE2 was found to be upregulated by >2-fold in NHBE cells exposed to CSE, as well as nicotine, banana, or chocolate EVE, while TMPRSS2 was only upregulated by CSE or nicotine EVE exposure. These findings suggest...
Source: Cell Research - November 26, 2022 Category: Cytology Authors: Rhys Hamon Miranda P Ween Source Type: research

Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine
CONCLUSION: Salivary nicotine concentration seems to be limitedly associated with the concentration of sACE2.PMID:36195157 | PMC:PMC9527194 | DOI:10.1016/j.envres.2022.114443
Source: Environmental Research - October 4, 2022 Category: Environmental Health Authors: Samuel Bru Adri án González-Marrón Cristina Lid ón-Moyano Reyes Carballar Joan Marc Mart ínez-Láinez Hip ólito Pérez-Martín Marcela Fu Ra úl Pérez-Ortuño Montse Ballb è Jose A Pascual Esteve Fern ández Josep Clotet Jose M Mart ínez-Sánchez Source Type: research

Acute vaping of a golden Syrian hamster causes inflammatory response transcriptomic changes
CONCLUSION: To our knowledge, this is the first demonstration that the Syrian hamster is a viable model of e-cig vaping. In addition, this is the first report that e-cig vaping with nicotine can increase tissue factor gene expression in the lung. Our results show that even an acute exposure to e-cigarette vaping causes significant upregulation of mRNAs in the respiratory tract from pathways involving the renin-angiotensin system, coagulation, extracellular matrix remodeling, type 1 inflammation, fibrosis, oxidative stress response, NETosis, vasculogenesis, and angiogenesis.PMID:36041220 | DOI:10.1152/ajplung.00162.2022
Source: Am J Physiol Lung Ce... - August 30, 2022 Category: Respiratory Medicine Authors: Daniel M Hinds Heidi J Nick Tessa M Vallin Leslie A Bloomquist Sarah Christeson Preston E Bratcher Emily H Cooper John T Brinton Angela Bosco-Lauth Carl W White Source Type: research

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