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Drug: Melatonin
Nutrition: Vitamin C
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Total 92 results found since Jan 2013.
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Alleviation of cadmium-induced photoinhibition and oxidative stress by melatonin in Chlamydomonas reinhardtii
Environ Sci Pollut Res Int. 2023 Jun 3. doi: 10.1007/s11356-023-27561-6. Online ahead of print.ABSTRACTAs one of the most threatening challenges to the natural environment and human health, cadmium (Cd) pollution has seriously impacted natural organisms. Green algae, such as Chlamydomonas reinhardtii (C. reinhardtii), can provide a safer, lower cost, and more effective ecological approach to the treatment of heavy metal ions in wastewater due to their sorption properties. However, heavy metal ions affect C. reinhardtii when adsorbed. Melatonin is able to protect the plant body from damage when the plant is under biotic/abi...
Source: Cell Research - June 3, 2023 Category: Cytology Authors: Fangbing Qi Yu Gao Jiaqi Liu Xiangyu Yao Kai Han Ziyi Wu Yingjuan Wang Source Type: research
Potential application of melatonin in reducing boron toxicity in rice seedlings through improved growth, cell wall composition, proline, and defense mechanisms
Chemosphere. 2023 May 29:139068. doi: 10.1016/j.chemosphere.2023.139068. Online ahead of print.ABSTRACTMelatonin (MT) has been demonstrated to provide defense against both biotic and abiotic stressors. Boron toxicity (BT) can significantly limit the growth and production of plants. However, few studies have been conducted on whether MT is effective in attenuating B toxicity in different plants. In order to evaluate the efficacy of exogenous MT treatment in reducing the negative impact of BT on rice seedlings, this study examined the influence of MT on growth, antioxidant capacity, cell wall composition, and proline metabol...
Source: Chemosphere - May 31, 2023 Category: Chemistry Authors: Xinyu Li Muhammad Kamran Muhammad Hamzah Saleem Abdullah Ahmed Al-Ghamdi Fahad M Al-Hemaid Mohamed S Elshikh Shaopeng Zhao Muhammad Riaz Source Type: research
Protective effect of melatonin and ascorbic acid combination on sepsis-induced lung injury: An Experimental study
In conclusion, this study supports the potential synergistic protective effects of MEL and ASA in treating sepsis-induced lung injury. The combination therapy could effectively reduce oxidative stress, inflammation and improve antioxidant capacity in septic rats, suggesting a promising strategy for treating sepsis-induced lung injury.PMID:37199082 | DOI:10.1111/1440-1681.13780
Source: Clinical and Experimental Pharmacology and Physiology - May 18, 2023 Category: Drugs & Pharmacology Authors: Hilal Üstündağ Özlem Demir Bet ül Çiçek Mehmet Tahir Huyut Neslihan Y üce Taha Tavac ı Source Type: research
Role of Supplements in the Management of COVID-19 - A Comprehensive Review
Infect Disord Drug Targets. 2023 Mar 10. doi: 10.2174/1871526523666230310094646. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and patients with COVID-19 may be treated primarily with SARS CoV-2-targeting drugs and the therapeutic agents assisting in the management of COVID-19 complications. This review focuses on the supplements like vitamins, minerals, herbal constituents, and others that help prevent or manage negative outcomes among COVID-19 patients. The literature was searched in databases such as Medline/PubMed Central/...
Source: Infectious Disorders Drug Targets - March 10, 2023 Category: Infectious Diseases Authors: Rajkapoor Balasubramanian Naina Mohamed Pakkir Maideen Sudha Muthusamy Sambathkumar Ramanathan Mohamed Harsath Jahir Hussain Source Type: research
