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Melatonin: A look at protozoal and helminths
Biochimie. 2023 Aug 2:S0300-9084(23)00182-7. doi: 10.1016/j.biochi.2023.07.021. Online ahead of print.ABSTRACTMelatonin is a pleiotropic neurohormone found in different animal, plant, and microorganism species. It is a product resulting from tryptophan metabolism in the pineal gland and is widely known for its ability to synchronize the circadian rhythm to antitumor functions in different types of cancers. The molecular mechanisms responsible for its immunomodulatory, antioxidant and cytoprotective effects involve binding to high-affinity G protein-coupled receptors and interactions with intracellular targets that modulate...
Source: Biochimie - August 4, 2023 Category: Biochemistry Authors: Pablo Igor Ribeiro Franco Jos é Rodrigues do Carmo Neto Rhanoica Oliveira Guerra Priscilla Elias Ferreira da Silva Yarlla Loyane Lira Braga Mara R úbia Nunes Celes Liliana Borges de Menezes Marina Pacheco Miguel Juliana Reis Machado Source Type: research

Human follicular mites: Ectoparasites becoming symbionts
Mol Biol Evol. 2022 Jun 21:msac125. doi: 10.1093/molbev/msac125. Online ahead of print.ABSTRACTMost humans carry mites in the hair follicles of their skin for their entire lives. Follicular mites are the only metazoans tha continuously live on humans. We propose that Demodex folliculorum (Acari) represents a transitional stage from a host-injuring obligate parasite to an obligate symbiont. Here, we describe the profound impact of this transition on the genome and physiology of the mite. Genome sequencing revealed that the permanent host association of D. folliculorum led to an extensive genome reduction through relaxed sel...
Source: Mol Biol Cell - June 20, 2022 Category: Molecular Biology Authors: Gilbert Smith Alejandro Manzano Mar ín Mariana Reyes-Prieto C átia Sofia Ribeiro Antunes Victoria Ashworth Obed Nanjul Goselle Abdulhalem Abdulsamad A Jan Andr és Moya Amparo Latorre M Alejandra Perotti Henk R Braig Source Type: research

Malaria parasites and circadian rhythm: New insights into an old puzzle
Curr Res Microb Sci. 2020 Dec 14;2:100017. doi: 10.1016/j.crmicr.2020.100017. eCollection 2021 Dec.ABSTRACT•Discuss molecular components for the coordination of circadian rhythm of malaria parasites inside the vertebrate host.•Synthetic indole compounds show antimalarial activity in vitro against P.falciparum 3D7.•Plasmodium falciparum synchronizes in cell culture upon melatonin treatment.PMID:34841309 | PMC:PMC8610328 | DOI:10.1016/j.crmicr.2020.100017
Source: Cell Research - November 29, 2021 Category: Cytology Authors: Lucas Borges-Pereira B árbara K M Dias Maneesh Kumar Singh Celia R S Garcia Source Type: research

Molecular basis of synchronous replication of malaria parasites in the blood stage
Curr Opin Microbiol. 2021 Aug 21;63:210-215. doi: 10.1016/j.mib.2021.08.002. Online ahead of print.ABSTRACTThe search for host factors that leads to malaria parasite synchronization has been the focus of several laboratories. The host hormone melatonin synchronizes Plasmodium falciparum in culture by increasing the number of mature parasite stages through a PLC-IP3 activation. Melatonin signaling is linked to crosstalk between Ca2+-cAMP that results in PKA activation. Two other kinases, PfPK7 and PfeIK1, and the nuclear protein PfMORC that lacks melatonin sensitivity in the inducible knock-down parasites are also identifie...
Source: Current Opinion in Microbiology - August 24, 2021 Category: Microbiology Authors: Benedito M Dos Santos Pedro Hs Pereira C élia Rs Garcia Source Type: research

Seasons, circadian rhythms, sleep and suicidal behaviors vulnerability.
CONCLUSION: The suicide seasonality is very well documented showing a main peak in spring and another one in autumn. A suicide circadian distribution also exists depending of the suicidal behavior intensity and of the age. Numerous sleep disorders are also suicide risk factors and can be treated with chronotherapeutics. A better identification of seasonality, circadian rhythms and sleep abnormalities in suicidal behaviors could allow a better prevention in suicidal attempts and a reduction in death by suicide. PMID: 26746320 [PubMed - in process]
Source: L Encephale - January 12, 2016 Category: Psychiatry Tags: Encephale Source Type: research