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Drug: Melatonin
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Total 42 results found since Jan 2013.

Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1/clock interruption
CONCLUSIONS: Our data indicate that melatonin treatment attenuates CRSD-induced cognitive impairment via regulating HDAC3-Bmal1/Clock interaction. These findings explore a broader understanding of the relationship between sleep and cognition and provide a potential new therapeutic target for cognitive impairment.PMID:37721401 | DOI:10.1111/cns.14474
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Yujie Hu Yefan Lv Xiaoyan Long Guoshuai Yang Jinxia Zhou Source Type: research

Effects of endogenous and exogenous N-acety-5-methoxy kynuramine on object recognition memory in male C3H mice
Horm Behav. 2023 Feb 23;150:105329. doi: 10.1016/j.yhbeh.2023.105329. Online ahead of print.ABSTRACTPrevention of dementia is important, because it is a leading cause of disability in elderly people. We previously reported that acute intraperitoneal treatment with N-acety-5-methoxy kynuramine (AMK), a melatonin (MEL) metabolite, enhanced long-term object recognition memory in ICR mice, a MEL deficient strain. Despite the presumable availability of AMK for dementia, its effects on cognitive performance have not been elucidated. It is unclear whether endogenous AMK is responsible for modulating long-term memory performance. ...
Source: Hormones and Behavior - February 25, 2023 Category: Endocrinology Authors: Hikaru Iwashita Masahiro Sano Atsuhiko Chiba Source Type: research

Nano-melatonin and-histidine modulate adipokines and neurotransmitters to improve cognition in HFD-fed rats: A formula to study
In this study, obese rat model was established by feeding high fat diet (HFD) composed of 25% fats (soybean oil) for 8 weeks, accompanied by melatonin (10 mg/kg), histidine (780 mg/kg), and combination of both in conventional form and nanoform. At the end of the study, adiposity hormones, neuronal monoamines and amino acids, brain derived neurotrophic factor (BDNF) and zonula occluden-1 (ZO-1) were assessed. HFD feeding resulted in significant weight gain and poor performance on cognitive test. Coadministration of histidine in the nanoform increased the level of ZO-1; an indicator of improving the brain barrier integrity, ...
Source: Biochimie - November 9, 2022 Category: Biochemistry Authors: Heba Ahmed Hegazy Dina M Abo-ElMatty Omar Farid Sami Saleh Maivel H Ghattas Nesreen Nabil Omar Source Type: research

Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Effects of Maternal Nutrient Restriction and Melatonin Supplementation on Cardiomyocyte Cell Development Parameters Using Machine Learning Techniques
This study provides evidence that restricted maternal nutrition leads to a reduction in the number of cardiomyocytes while melatonin treatment can mitigate some of these disturbances.PMID:35883365 | DOI:10.3390/ani12141818
Source: Cell Research - July 27, 2022 Category: Cytology Authors: Mitra Mazinani Zully E Contreras-Correa Vahid Behzadan Shreya Gopal Caleb O Lemley Source Type: research

Adipose tissue ‐derived stem cells as a potential candidate in treatment of Alzheimer's disease: A systematic review on preclinical studies
Adipose tissue-derived stem cells as a potential candidate in treatment of Alzheimer's disease: a systematic review on preclinical studies AbstractIn recent years, numerous investigations have evaluated the efficacy of adipose tissue-derived stem cells (ADSCs) and their exosome transplantation in managing Alzheimer's disease (AD) in different animal models. However, there are still many contradictions among the studies that hinder reaching a reliable conclusion. Therefore, we aimed to systematically review the existing evidence regarding the efficacy of ADSCs administration in treatment of AD. The systematic search was con...
Source: Pharmacology Research and Perspectives - June 19, 2022 Category: Drugs & Pharmacology Authors: Arian Madani Neishaboori, Azadeh Eshraghi, Arezou Tasouji Asl, Marjan Shariatpanahi, Mahmoud Yousefifard, Ali Gorji Tags: REVIEW ARTICLE Source Type: research

Night melatonin levels affect cognition in diurnal animals: Molecular insights from a corvid exposed to an illuminated night environment
This study investigated the role of nocturnal melatonin secretion in the cognitive performance of diurnal animals. An initial experiment measured the cognitive performance in Indian house crows treated for 11 days with 12 h light at 1.426 W/m2 (∼150 lux) coupled with 12 h of 0.058 W/m2 (∼6-lux) dim light at night (dLAN) or with absolute darkness (0 lux dark night, LD). dLAN treatment significantly decreased midnight melatonin levels and negatively impacted cognitive performance. Subsequently, the role of exogenous melatonin (50 μg; administered intraperitoneally half an hour before the night began) was assessed on the...
Source: Environmental Pollution - June 17, 2022 Category: Environmental Health Authors: Amaan Buniyaadi Abhilash Prabhat Sanjay Kumar Bhardwaj Vinod Kumar Source Type: research

Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology. Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs