Filtered By:
Specialty: Neurology
Drug: Magnesium

This page shows you your search results in order of relevance. This is page number 3.

Order by Relevance | Date

Total 54 results found since Jan 2013.

Quantifying the amount of greater brain ischemia protection time with pre-hospital vs. in-hospital neuroprotective agent start
The objective of this study is to quantify the increase in brain-under-protection time that may be achieved with pre-hospital compared with the post-arrival start of neuroprotective therapy among patients undergoing endovascular thrombectomy. In order to do this, a comparative analysis was performed of two randomized trials of neuroprotective agents: (1) pre-hospital strategy: Field administration of stroke therapy-magnesium (FAST–MAG) Trial; (2) in-hospital strategy: Efficacy and safety of nerinetide for the treatment of acute ischemic stroke (ESCAPE-NA1) Trial. In the FAST-MAG trial, among 1,041 acute ischemic stroke p...
Source: Frontiers in Neurology - September 13, 2022 Category: Neurology Source Type: research

Effect of Magnesium on Deterioration and Symptomatic Hemorrhagic Transformation in Cerebral Ischemia: An Ancillary Analysis of the FAST-MAG Trial
Conclusions: Treatment with Mg did not significantly reduce rates of clinical deterioration or symptomatic HT. Future analysis should address whether treatment with Mg could have influenced the subgroup with low serum Mg at baseline.Cerebrovasc Dis
Source: Cerebrovascular Diseases - January 4, 2023 Category: Neurology Source Type: research

Modified Rankin Scale Disability Status at Day 4 Poststroke is an Informative Predictor of Final Day 90 Outcome (P6.271)
Conclusions:In acute stroke patients, the 4d modified Rankin global disability assessment is highly informative regarding final 3 month mRS disability outcome, alone, and even more strongly in combination with baseline prognostic variables. The 4d mRS is a useful measure for imputing final patient disability outcome in clinical trials and quality improvement programs.Disclosure: Dr. Asanad has nothing to disclose. Dr. Starkman has received research support from the National Institute of Health, Stryker, Biogen IDEC, Neuravi, Genentech, Covidien, and Astra-Zeneca. Dr. Hamilton has nothing to disclose. Dr. Conwit has nothing...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Asanad, S., Starkman, S., Hamilton, S., Conwit, R., Sanossian, N., Saver, J. Tags: Cerebrovascular Disease Health Services Research Source Type: research

Episodic Aphasia After Subdural Hemorrhage Due to Cortical Spreading Depression: A Case Report (P2.124)
CONCLUSION:CSD can be difficult to detect due to its brief and focal pathology. EEG should be done to exclude seizure and MRI/MRA to exclude stroke. CSD should be considered with a focal deficit with brief episodes when all other tests are negative. Better knowledge of the pathophysiolgy of CSD and its possible manifestations may facilitate a better way to diagnose as well as treatment to prevent CSD from causing permanent damage.Disclosure: Dr. Grayson has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Forteza has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Grayson, J., Shah, N., Patel, S., Forteza, A. Tags: Cerebrovascular Disease and Interventional Neurology: Behavioral, Cognitive, and Miscellaneous Source Type: research

Admission Hypomagnesemia Predicts Primary Intracerebral Hemorrhage Volume (P3.093)
CONCLUSIONS: Hypomagnesemia was associated with higher admission ICH volumes in patients with lower ICH severity. While the study was limited by small numbers, a similar relationship between magnesium and ICH volume was not detected amongst patients with more severe ICH. Future studies are needed to determine if correction improves functional outcome in any targeted group of patients with ICH.Disclosure: Dr. Shiue has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. Sands has nothing to disclose. Dr. Martin-Schild has received personal compensation for activities with Genentech as a speakers bureau participant....
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shiue, H., Boehme, A., Sands, K., Martin-Schild, S., Hays Shapshak, A., Lyerly, M., Gadpaille, A., Khawaja, A., Sisson, A., Alvi, M., George, A., Harrigan, M. Tags: Cerebrovascular Disease and Interventional Neurology: Intracerebral Hemorrhage Source Type: research

Prehospital Initiation of Magnesium Sulfate in Patients with Acute Intracerebral Hemorrhage (S39.003)
Conclusions: Prehospital initiation permitted start of Mg therapy within the first 45 minutes of symptom onset in over half of patients, but did not alter rates of clinical deterioration in the first hours or disability at 3 months. Study Supported by NIH-NINDS Award U01 NS 44364Disclosure: Dr. Sanossian has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals, Inc. as a speakers bureau participant. Dr. Starkman has received research support from the National Institutes of Health, Lundbeck Research USA, Inc., Mitsubishi Tanabe Pharma, and Neurobiological Technologies, Inc. Dr. Liebeskind ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sanossian, N., Starkman, S., Liebeskind, D., Hamilton, S., Eckstein, M., Stratton, S., Pratt, F., Conwit, R., Sung, G., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: Intracerebral Hemorrhage Source Type: research

Clinical Reasoning: A 44-year-old woman with headache followed by sudden neurologic decline
A 44-year-old woman with a history of migraines and idiopathic intracranial hypertension presented to the emergency room with 1 day of headache and nausea. She had been otherwise healthy with no sick contacts. She was afebrile without nuchal rigidity, rash, or cardiac murmur, and her neurologic examination was normal. Migraine therapy was initiated with IV prochlorperazine, ketorolac, and magnesium. Two hours later, she developed fever (101.4°F) and confusion, continually stating, "It hurts," but unable to answer questions or follow commands despite an otherwise unremarkable examination. Noncontrast head CT demonstrate...
Source: Neurology - March 25, 2013 Category: Neurology Authors: Berkowitz, A. L., Kimchi, E. Y., Hwang, D. Y., Vaitkevicius, H., Henderson, G. V., Feske, S. K., Chou, S. H.- Y. Tags: Hydrocephalus, Stroke in young adults, Meningitis, Critical care RESIDENT AND FELLOW SECTION Source Type: research

Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery Clinical Sciences
Conclusions— Magnesium administered intravenously during cardiac surgery does not reduce postoperative cognitive dysfunction. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00041392.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Mathew, J. P., White, W. D., Schinderle, D. B., Podgoreanu, M. V., Berger, M., Milano, C. A., Laskowitz, D. T., Stafford-Smith, M., Blumenthal, J. A., Newman, M. F., for the Neurologic Outcome Research Group (NORG) of The Duke Heart Center, Neurologic Out Tags: Clinical Sciences Source Type: research

Mitochondrial Dysfunction in Migraine
Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and migraine: (1) Biochemical evidence: Abnormal mt function translates into high intracellular penetration of Ca2+, excessive production of free radicals, and deficient oxidative phosphorylation, which ultimately causes energy failure in neurons and astrocytes, thus triggering ...
Source: Seminars in Pediatric Neurology - September 1, 2013 Category: Neurology Authors: William R. Yorns, H. Huntley Hardison Source Type: research

Letter by Derakhshan Regarding Article, "Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function Following Cardiac Surgery" Letters to the Editor
Source: Stroke - February 24, 2014 Category: Neurology Authors: Derakhshan, I. Tags: Other Research Letters to the Editor Source Type: research

Response to Letter Regarding Article, "Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery" Letters to the Editor
Source: Stroke - February 24, 2014 Category: Neurology Authors: Mathew, J. P., Laskowitz, D. T., Newman, M. F. Tags: Behavioral/psychosocial - CV surgery Letters to the Editor Source Type: research

Validation of the ICH Score in Hyperacute Intracerebral Hemorrhage (S25.004)
Conclusions: In the hyperacute setting, all patients with ICH score >=4 had poor outcome. Less than 10%of the patients with an ICH score >=2 had a good outcome.Disclosure: Dr. Bulic has nothing to disclose. Dr. Sanossian has received personal compensation for activities with Boehringer-Ingelheim Pharmaceutical Inc. Dr. Starkman has received research support from the National Institutes of Health, Lundbeck, Mitsubishi, and NTI. Dr. Liebeskind has received personal compensation for activities with Concentric Medical, Inc. and CoAxia, Inc. Dr. Villablanca has nothing to disclose. Dr. Hamilton has nothing to disclose. Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bulic, S., Sanossian, N., Starkman, S., Liebeskind, D., Villablanca, P., Hamilton, S., Conwit, R., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: Hemorrhage, Aneurysms, and Vascular Malformations Source Type: research

Nutrition and dietary supplements in neurological diseases.
Abstract "Healthy" diets and supplements are widely used for prevention and disease modification in vascular, inflammatory and degenerative neurological diseases. Apart from a large number of cross-sectional and prospective cohort studies, there are only few interventional studies on individual dietary measures. A recent study confirmed the stroke preventive effect of a Mediterranean diet rich in olive oil and nuts; a ketogenic diet reduces seizure frequency in epilepsy. Supplementation of riboflavin, magnesium and coenzyme Q10 are probably effective in migraine prophylaxis. Creatine can improve muscle strength in...
Source: Der Nervenarzt - November 19, 2014 Category: Neurology Authors: Erbguth F, Himmerich H Tags: Nervenarzt Source Type: research

Neuroprotection After Major Cardiovascular Surgery
Opinion statement Neurologic injury is a common complication of major cardiovascular procedures including coronary artery bypass graft (CABG) surgery, coronary valve replacement, and aortic aneurysm surgery. However, despite ongoing research in the field of neuroprotection, there are currently few pharmacologic and interventional options to effectively protect the brain and spinal cord in the postoperative period. CSF drainage after aortic surgery currently stands as the only neuroprotective intervention that has been consistently shown to protect the spinal cord from ischemic injury, leading to significantly few...
Source: Current Treatment Options in Neurology - May 15, 2015 Category: Neurology Source Type: research