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Infectious Disease: Pandemics
Drug: Magnesium
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Total 79 results found since Jan 2013.
Mechanistic Insight into the role of Vitamin D and Zinc in Modulating Immunity Against COVID-19: A View from an Immunological Standpoint
Biol Trace Elem Res. 2023 Mar 9:1-15. doi: 10.1007/s12011-023-03620-4. Online ahead of print.ABSTRACTThe pathophysiology of coronavirus disease-19 (COVID-19) is characterized by worsened inflammation because of weakened immunity, causing the infiltration of immune cells, followed by necrosis. Consequently, these pathophysiological changes may lead to a life-threatening decline in perfusion due to hyperplasia of the lungs, instigating severe pneumonia, and causing fatalities. Additionally, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause mortality due to viral septic shock, resulting from unr...
Source: Biological Trace Element Research - March 8, 2023 Category: Biology Authors: Nuzhat Ahsan Mohammad Imran Yousuf Mohammed Fatme Al Anouti Mohammad Idreesh Khan Tanushree Banerjee Mohd Adnan Fauzia Ashfaq Marek Kieliszek Syed Amir Ashraf Afrozul Haq Source Type: research
Hidden hydrogen: Earth may hold vast stores of a renewable, carbon-free fuel
IN THE SHADE
of a mango tree, Mamadou Ngulo Konaré recounted the legendary event of his childhood. In 1987, well diggers had come to his village of Bourakébougou, Mali, to drill for water, but had given up on one dry borehole at a depth of 108 meters. “Meanwhile, wind was coming out of the hole,” Konaré told Denis Brière, a petrophysicist and vice president at Chapman Petroleum Engineering, in 2012. When one driller peered into the hole while smoking a cigarette, the wind exploded in his face.
“He didn’t die, but he was burned,” Konaré continued. “And now we had a huge fire. The color of the fire...
Source: ScienceNOW - February 16, 2023 Category: Science Source Type: news
Piezoelectric biosensors and nanomaterials-based therapeutics for coronavirus and other viruses: A Mini-review
Curr Top Med Chem. 2022 Dec 26. doi: 10.2174/1568026623666221226091907. Online ahead of print.ABSTRACTSince late 2019, the novel coronavirus (COVID-19) pandemic has caused considerable mortality worldwide. This pandemic raised concerns and provoked research on the diagnosis and treatment of viruses-based diseases. The accurate diagnosis of a virus requires high specificity and sensitivity. Piezoelectric sensors are analytical devices that work on mass-sensitivity-based micromechanical transducers. The change in the mass by the interaction between biological elements and the frequency is recorded by measuring the alternate ...
Source: Current Topics in Medicinal Chemistry - December 27, 2022 Category: Chemistry Authors: Madeshwaran Sekkarapatti Ramasamy Rakesh Bhaskar Sung Soon Han Source Type: research
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2
Biochem J. 2022 Oct 7:BCJ20220380. doi: 10.1042/BCJ20220380. Online ahead of print.ABSTRACTCoronaviruses have been responsible for multiple challenging global pandemics, including coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Papain-like protease (PLpro), one of two cysteine proteases responsible for the maturation and infectivity of SARS-CoV-2, processes and liberates functional proteins from the viral polyproteins and cleaves ubiquitin and ISG15 modifications to inhibit innate immune sensing. Consequently, PLpro is an attractive target for developing...
Source: The Biochemical Journal - October 7, 2022 Category: Biochemistry Authors: Cameron Lee Shetler Juliana C Ferreira Thyago H S Cardoso Edson M A Silva Nitin K Saksena Wael M Rabeh Source Type: research
The National COVID-19 Clinical Evidence Taskforce: pregnancy and perinatal guidelines
Med J Aust. 2022 Oct 2. doi: 10.5694/mja2.51729. Online ahead of print.ABSTRACTINTRODUCTION: Pregnant women are at higher risk of severe illness from coronavirus disease 2019 (COVID-19) than non-pregnant women of a similar age. Early in the COVID-19 pandemic, it was clear that evidenced-based guidance was needed, and that it would need to be updated rapidly. The National COVID-19 Clinical Evidence Taskforce provided a resource to guide care for people with COVID-19, including during pregnancy. Care for pregnant and breastfeeding women and their babies was included as a priority when the Taskforce was set up, with a Pregnan...
Source: Med J Aust - October 2, 2022 Category: General Medicine Authors: Caroline Se Homer Vijay Roach Leila Cusack Michelle L Giles Clare Whitehead Wendy Burton Teena Downton Glenda Gleeson Adrienne Gordon Karen Hose Jenny Hunt Jackie Kitschke Nolan McDonnell Philippa Middleton Jeremy Jn Oats Antonia W Shand Kellie Wilton Jos Source Type: research
Top 20 Research Studies of 2021 for Primary Care Physicians
This article summarizes the top 20 research studies of 2021 identified as POEMs (patient-oriented evidence that matters) that did not address the COVID-19 pandemic. Sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists prevent adverse cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and also reduce all-cause and cardiovascular mortality. Most older adults (mean age, 75 years) with prediabetes do not progress to diabetes. Among patients in this age group with type 2 diabetes treated with medication, an A1C level of less than 7% is associated with increased risk of...
Source: American Family Physician - July 15, 2022 Category: Primary Care Authors: Mark H Ebell Roland Grad Source Type: research
