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Specialty: Biochemistry
Drug: Insulin
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Total 2083 results found since Jan 2013.
Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis in diabetic kidney disease progression
CONCLUSION: Deficient insulin regulation of ENT2 activity contributes to chronically high adenosine levels and glomerular alterations that underline diabetic kidney disease progression.PMID:37734469 | DOI:10.1016/j.bbadis.2023.166890
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Raibel Suarez Carolina Villarreal Yessica Nahuelp án Claudia Jara Carlos Oyarz ún Sebasti án Alarcón Montserrat M D íaz-Encarnación Elena Guill én-Gómez Claudia Quezada Rody San Mart ín Source Type: research
D-pinitol ameliorated H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans
In this study, we intended to explore the anti-aging mechanism of DP, utilizing computer modeling techniques. The results demonstrated that DP significantly delayed H2O2-induced cellular senescence. Model PC12 cells treated with DP exhibited increased cell viability, increased antioxidant enzyme activity (SOD, CAT), and reduced ROS and MDA levels. Furthermore, DP was discovered to have a positive effect on healthy longevity. In C. elegans, DP treatment enhanced lifespan, stress capacity, antioxidant capacity (T-SOD/CAT/GSH-Px/MDA/ROS), and altered aging-related indicators of lipofuscin accumulation, pharyngeal pump rate, m...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 21, 2023 Category: Biochemistry Authors: Miaosi Zhang Zhe Xu Liangyong Shao Jilite Wang Zouyan He Yumei Jiang Ye Zhang Hao Wang Source Type: research
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats
CONCLUSIONS: These findings indicate that MOSA can exert prolonged adverse effects manifested as metabolic dysfunction in male offspring. Therefore, surveillance and management of OSA during pregnancy may be necessary to prevent and alleviate MAFLD in offspring.PMID:37730152 | DOI:10.1016/j.bbadis.2023.166889
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Ruhua Wang Wei Feng Yan Wang Yonghong Jiang Yiguang Lin Xueqing Chen Source Type: research
Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte
This study aims to uncover novel substrates of PTP1B in podocytes and validate a leading candidate. To this end, using substrate-trapping and mass spectroscopy, we identified putative substrates of this phosphatase and investigated the actin cross-linking cytoskeletal protein alpha-actinin4. PTP1B and alpha-actinin4 co-localized in murine and human glomeruli and transiently transfected E11 podocyte cells. Additionally, podocyte PTP1B deficiency in vivo and culture was associated with elevated tyrosine phosphorylation of alpha-actinin4. Conversely, reconstitution of the knockdown cells with PTP1B attenuated alpha-actinin4 t...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Ming-Fo Hsu Yoshihiro Ito Jai Prakash Singh Shu-Fang Hsu Alan Wells Kuang-Yu Jen Tzu-Ching Meng Fawaz G Haj Source Type: research
Construction and functional evaluation of oral long-acting insulin hydrogel microparticles based on physical and chemical double crosslinking
The objective of this study was to enhance the convenience and effectiveness of diabetes treatment by developing hydrogel microparticles as an oral insulin delivery system, aiming to reduce the necessity for frequent treatments. The hydrogel microparticles were prepared with polysaccharides through a combination of physical and chemical crosslinking method, they achieved good results in insulin loading efficiency (70 %), insulin release efficiency (98 %) and sustained release time (>20 h). The effective transmembrane transport was validated using an intestinal epithelial cell model, which demonstrated a continuous hypog...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: ShengQin Chen QingYa Miao Yang Liu Qiao Xiao YuKai Lin Yu Yang FengBiao Guo Source Type: research
Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites
In this study, a heterogeneous acidic heteropolysaccharide with high molecular weight mainly composed of fructose was isolated from Atractylodes macrocephala Koidz (AMP). Supplementation with AMP was shown to improve diet-induced GMD in a rat model, including decreasing the levels of serum triglycerides, total cholesterol, and glucose, and improving hepatic lipidosis and islet cells morphologies. AMP-treated rats also exhibited modified intestinal flora with enrichments of intestinal Lactobacillus and Rothia species, which was accompanied by increased tryptophan metabolites such as indole-3-propionic acid, indole, tryptami...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Ziwen He Jingyan Guo Huiwen Zhang Jingjing Yu Yiqing Zhou Yajun Wang Ting Li Meiqiu Yan Bo Li Yigong Chen Suhong Chen Guiyuan Lv Jie Su Source Type: research
Amino acid metabolism dysregulation associated with inflammation and insulin resistance in HIV-infected individuals with metabolic disorders
In this study, we performed targeted metabolomic analyses on 64 patients with HIV/AIDS and 21 healthy controls. Twenty-four amino acids and selected intermediate metabolites in the serum were quantitatively detected using high-performance liquid chromatography-tandem mass spectrometry, and characteristic changes and metabolic pathways were analyzed in HIV-infected patients with different degrees of abnormal glucose and lipid metabolism. Spearman's partial correlation was used to analyze the association between amino acids, biochemical parameters, and inflammatory cytokines. The results showed that the main metabolic pathwa...
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Jing Zhang Yanfang Chen Mingli Wang Liuting Zhong Linghua Li Zhongwen Yuan Shangrong Zou Source Type: research
Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance
This study aimed to identify significantly different metabolites and related metabolic pathways in the serum of acne vulgaris patients with or without insulin resistance. LC-MS/MS was used to analyze serum samples from patients about acne with insulin resistance (n = 51) and acne without insulin resistance (n = 69) to identify significant metabolites and metabolic pathways. In this study, 18 significant differential metabolites were screened for the first time. In the positive-ion mode, the upregulated substances were creatine, sarcosine, D-proline, uracil, Phe-Phe, L-pipecolic acid, and DL-phenylalanine; the downregulated...
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Qingqing He Huiling Shu Yu Peng Yang Xu Li Liu Jie Zhou Juan Zhao Xia Xiong Changqiang Li Source Type: research
Injectable and Self-Adaptive Gel Scaffold Based on Heparin Microspheres for Adipogenesis of Human Adipose-Derived Stem Cells
Biomacromolecules. 2023 Sep 18. doi: 10.1021/acs.biomac.3c00348. Online ahead of print.ABSTRACTAn injectable and self-adaptive heparin microsphere-based cell scaffold was developed to achieve adipose regeneration. Simultaneously, the cell scaffold exhibited a dynamic architecture, self-regulated glucose levels, sustained insulin delivery, and steady viscoelastic properties for adipogenesis. The dynamic cell scaffold is cross-linked by the boronate-diol interaction among heparin-based microspheres, which have boronate and maltose groups. Because of the boronate-maltose ester bonds, the gelatinous complex would be partially ...
Source: Biomacromolecules - September 18, 2023 Category: Biochemistry Authors: Xinyue Zhai Xinwei Tao Yuqian Wu Kesun Jin Huaping Tan Tianle Zhou Yong Chen Source Type: research
The dual role of citrate in cancer
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188987. doi: 10.1016/j.bbcan.2023.188987. Online ahead of print.ABSTRACTCitrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where it performs several functions. In normal cells, citrate sustains protein acetylation, lipid synthesis, gluconeogenesis, insulin secretion, bone tissues formation, spermatozoid mobility, and immune response. Dysregulation of citrate metabolism is implicated in several pathologies, including cancer. Here we discuss how cancer cells use citrate to sustain their proliferation, survival, and metastatic progression. Also...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Philippe Icard Luca Simula Grit Zahn Marco Alifano Maria E Mycielska Source Type: research
Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice
Amino Acids. 2023 Sep 16. doi: 10.1007/s00726-023-03332-y. Online ahead of print.ABSTRACTAbnormal fat accumulation, enhanced free fatty acids (FFA) release, and their metabolites cause insulin resistance (IR) in major glucose-lipid metabolic organs such as skeletal muscle and adipose tissue. However, excessive lipolysis and FFA release from adipose tissue elevate plasma FFA levels leading to oxidative stress and skeletal muscle IR. Indeed, in obese individuals, there is enhanced pro-inflammatory secretion from adipose tissue influencing insulin signaling in skeletal muscles. Here, we investigated the effect of PSTi8 on FFA...
Source: Amino Acids - September 16, 2023 Category: Biochemistry Authors: Richa Garg Arun Agarwal Roshan Katekar Umesh Kumar Goand Naveen Singh Shubhi Yadav Shivam Rathaur Saurabh Verma Debalina Maity Sachin Vishwakarma Jiaur R Gayen Source Type: research
Effects of in vitro fermentation of Atractylodes chinensis (DC.) Koidz. polysaccharide on fecal microbiota and metabolites in patients with type 2 diabetes mellitus
This study has laid a theoretical foundation for AKP application in functional foods.PMID:37716665 | DOI:10.1016/j.ijbiomac.2023.126860
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: Xin Zhang Qian Ma Lina Jia Hongpeng He Tongcun Zhang Weiguo Jia Liying Zhu Wei Qi Nan Wang Source Type: research
Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice
Amino Acids. 2023 Sep 16. doi: 10.1007/s00726-023-03332-y. Online ahead of print.ABSTRACTAbnormal fat accumulation, enhanced free fatty acids (FFA) release, and their metabolites cause insulin resistance (IR) in major glucose-lipid metabolic organs such as skeletal muscle and adipose tissue. However, excessive lipolysis and FFA release from adipose tissue elevate plasma FFA levels leading to oxidative stress and skeletal muscle IR. Indeed, in obese individuals, there is enhanced pro-inflammatory secretion from adipose tissue influencing insulin signaling in skeletal muscles. Here, we investigated the effect of PSTi8 on FFA...
Source: Amino Acids - September 16, 2023 Category: Biochemistry Authors: Richa Garg Arun Agarwal Roshan Katekar Umesh Kumar Goand Naveen Singh Shubhi Yadav Shivam Rathaur Saurabh Verma Debalina Maity Sachin Vishwakarma Jiaur R Gayen Source Type: research
