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Cancers, Vol. 15, Pages 4651: Is Insulin Receptor Substrate4 (IRS4) a Platform Involved in the Activation of Several Oncogenes?
Miguel A. Ortega
The IRS (insulin receptor substrate) family of scaffold proteins includes insulin receptor substrate-4 (IRS4), which is expressed only in a few cell lines, including human kidney, brain, liver, and thymus and some cell lines. Its N-terminus carries a phosphotyrosine-binding (PTB) domain and a pleckstrin homology domain (PH), which distinguishes it as a member of this family. In this paper, we collected data about the molecular mechanisms that explain the relevance of IRS4 in the development of cancer and identify IRS4 differences that distinguish it from IRS1 and IRS2. Search engines and different dat...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Luis G. Guijarro Francisco Javier Justo Bermejo Diego Liviu Boaru Patricia De Castro-Martinez Diego De Leon-Oliva Oscar Fraile-Mart ínez Cielo Garcia-Montero Melchor Alvarez-Mon Mar ía del Val Toledo-Lobo Miguel A. Ortega Tags: Review Source Type: research
Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis
CONCLUSIONS: Apparently healthy individuals without cardiac 18F-FDG uptake have higher HOMA-IR and higher prevalence of MetS traits, cardiovascular risk factors, and early atherosclerosis. An improvement in cardiometabolic profile is associated with the recovery of myocardial 18F-FDG uptake at follow-up.PMID:37713581 | DOI:10.2337/dc23-0871
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Ana Devesa Valentin Fuster Ravi Vazirani In és García-Lunar Bel én Oliva Samuel Espa ña Andrea Moreno-Arciniegas Javier Sanz Cristina Perez-Herreras H éctor Bueno Enrique Lara-Pezzi Ana Garc ía-Alvarez Vicente Mart ínez de Vega Leticia Fern ández- Source Type: research
The tissue-specific metabolic effects of the PPAR α agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study
CONCLUSIONS: Ciprofibrate treatment increased hepatic lipid accumulation and lowered MRgluc, without affecting whole-body insulin sensitivity. Furthermore, parameters of cardiac function or cardiac energy status were not altered upon ciprofibrate treatment.PMID:37670579 | DOI:10.1002/oby.23874
Source: Obesity - September 6, 2023 Category: Eating Disorders & Weight Management Authors: Vera H W de Wit-Verheggen Froukje Vanweert Juho Raiko Viktor Li énard Gert Schaart Anne Gemmink Emmani B M Nascimento Matthijs K C Hesselink Joachim E Wildberger Roel Wierts Peter J Joris Joel Haas David Montaigne Bart Staels Esther Phielix Patrick Schra Source Type: research
The Effect of Testosterone Replacement Therapy on Nonalcoholic Fatty Liver Disease in Older Hypogonadal Men
CONCLUSIONS: Our study did not show improvement of NAFLD in older hypogonadal men after 12 months of T versus placebo treatment, as assessed by three clinical scores and liver CT for hepatic steatosis. Future studies with longer treatment duration and additional NAFLD diagnostic modalities as primary outcome are warranted.PMID:37656011 | DOI:10.1210/clinem/dgad511
Source: The Journal of Clinical Endocrinology and Metabolism - September 1, 2023 Category: Endocrinology Authors: Hae Seung Lee Sang Hun Han Ronald Swerdloff Youngju Pak Matthew Budoff Christina Wang Source Type: research
Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging
Am J Physiol Heart Circ Physiol. 2023 Aug 25. doi: 10.1152/ajpheart.00202.2023. Online ahead of print.ABSTRACTWith sparse treatment options, cardiac disease remains a significant cause of death among humans. As a person ages, mitochondria break down and the heart becomes less efficient. Heart failure is linked to many mitochondria-associated processes, including endoplasmic reticulum stress, mitochondrial bioenergetics, insulin signaling, autophagy, and oxidative stress. The roles of key mitochondrial complexes that dictate the ultrastructure, such as the mitochondrial contact site and cristae organizing system (MICOS), in...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 25, 2023 Category: Physiology Authors: Zer Vue Kit Neikirk Larry Vang Edgar Garza-Lopez Trace A Christensen Jianqiang Shao Jacob Lam Heather K Beasley Andrea G Marshall Amber Crabtree Josephs Anudokem Benjamin Rodriguez Benjamin Kirk Serif Bacevac Taylor Barongan Bryanna Shao Dominique C Steph Source Type: research
