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Drug: Insulin
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Total 1426 results found since Jan 2013.
Physical fitness training in Subacute Stroke (PHYS-STROKE) - study protocol for a randomised controlled trial
DiscussionThe goal of this endpoint-blinded, phase III randomised controlled trial is to provide evidence to guide post-stroke physical fitness-based rehabilitation programmes, and to elucidate the mechanisms underlying this intervention.Trial registration: Registered in ClinicalTrials.gov with the Identifier NCT01953549.
Source: Trials - February 3, 2014 Category: Journals (General) Authors: Agnes FlöelCordula WernerUlrike GrittnerStefan HesseMichael JöbgesJanet KnaussMichael SeifertElisabeth Steinhagen-ThiessenMehmet GövercinChristian DohleWolfgang FischerRegina SchliederAlexander NaveAndreas MeiselMartin EbingerIan Wellwood Source Type: research
Estimated Prestroke Peak VO2 Is Related to Circulating IGF-1 Levels During Acute Stroke
Conclusions. Improving aerobic fitness prior to stroke may be beneficial by increasing baseline IGF-1 levels. These results set the groundwork for future clinical trials to determine whether high IGF-1 and aerobic fitness are beneficial to stroke recovery by providing neuroprotection and improving function.
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Mattlage, A. E., Rippee, M. A., Abraham, M. G., Sandt, J., Billinger, S. A. Tags: Original Research Articles Source Type: research
Insulin resistance in ischemic stroke
AbstractInsulin resistance often refers to a pathological condition in which cells fail to respond to the normal actions of insulin. Increasing literature has noted a critical role of insulin resistance in the pathogenesis of ischemic stroke. Insulin resistance plays an important role in the pathogenesis of ischemic stroke via enhancing advanced changes of atherosclerosis. A variety of literature indicates that insulin resistance enhances platelet adhesion, activation and aggregation which are conducive to the occurrence of ischemic stroke. Insulin resistance also induces hemodynamic disturbances and contributes to the ons...
Source: Metabolic Brain Disease - June 21, 2017 Category: Neurology Source Type: research
European Academy of Neurology – European Stroke Organisation consensus statement and practical guidance for pre‐hospital management of stroke
This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 7, 2017 Category: Neurology Authors: A. Kobayashi, A. Czlonkowska, G.A. Ford, A.C. Fonseca, G.J. Luijckx, J. Korv, N. P érez de la Ossa, C. Price, D. Russell, A. Tsiskaridze, M. Messmer‐Wullen, J. De Keyser Tags: Guidelines Source Type: research
European Academy of Neurology and European Stroke Organization consensus statement and practical guidance for pre ‐hospital management of stroke
ConclusionsThese guidelines inform on the contemporary approach to patients with suspected stroke in the pre‐hospital setting. Further studies, preferably randomized controlled trials, are required to examine the impact of particular interventions on quality parameters and outcome.
Source: European Journal of Neurology - January 12, 2018 Category: Neurology Authors: A. Kobayashi, A. Czlonkowska, G. A. Ford, A. C. Fonseca, G. J. Luijckx, J. Korv, N. P érez Ossa, C. Price, D. Russell, A. Tsiskaridze, M. Messmer‐Wullen, J. De Keyser Tags: Guideline Source Type: research
Neuroprotection by insulin-like growth factor-1 in rats with ischemic stroke is associated with microglial changes and a reduction in neuroinflammation
Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Ahmad Serhan, Joeri L. Aerts, EWGM Boddeke, Ron KooijmanAbstractWe and others have shown that insulin-like growth factor-1 (IGF-1) is neuroprotective when administered systemically shortly following stroke. In the current study, we addressed the hypothesis that microglia mediate neuroprotection by IGF-1 following ischemic stroke. Furthermore, we investigated whether IGF-1 modulates pro- and anti-inflammatory mediators in ischemic brain with a special reference to microglia. Ischemic stroke was induced in normal conscious Wistar rats by infusi...
Source: Neuroscience - December 16, 2019 Category: Neuroscience Source Type: research
Association between Serum Insulin-Like Growth Factor-1 and Neurological Severity in Acute Ischemic Stroke
CONCLUSIONS: This study showed that a higher serum IGF-1 level is associated with a lower NIHSS score at admission but not at 3 months. Further studies are required to clarify the usefulness of the serum IGF-1 level as a prognostic marker for ischemic stroke.PMID:33835740 | DOI:10.3988/jcn.2021.17.2.206
Source: Journal of Clinical Neurology - April 9, 2021 Category: Neurology Authors: Jeeun Lee Jeongjae Lee Minwoo Lee Jae Sung Lim Jin Hyouk Kim Kyung Ho Yu Mi Sun Oh Byung Chul Lee Source Type: research
