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Drug: Tamoxifen
Nutrition: Diets
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Total 46 results found since Jan 2013.
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research
Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice
CONCLUSION: Whole-body AT1R inhibition reduced atherosclerosis equivalently in both male and female mice; however, PTC-specific manipulation of the RAS components had no effects on hypercholesterolemia-induced atherosclerosis.PMID:37655218 | PMC:PMC10466789 | DOI:10.3389/fcvm.2023.1250234
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Masayoshi Kukida Naofumi Amioka Dien Ye Hui Chen Jessica J Moorleghen Ching-Ling Liang Deborah A Howatt Yuriko Katsumata Motoko Yanagita Hisashi Sawada Alan Daugherty Hong S Lu Source Type: research
Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis
Biochem Biophys Res Commun. 2023 Jul 22;676:78-83. doi: 10.1016/j.bbrc.2023.07.042. Online ahead of print.ABSTRACTOur previous studies demonstrated that mice with global CD47 deficiency are lean and resistant to diet or aging-associated obesity and metabolic complications. This protective effect is partially through modulating brown fat function. To definitively determine the role of brown fat CD47 in age-related metabolic homeostasis, inducible brown adipocyte-specific cd47 deficient mice were generated by crossbreeding cd47 floxed mice with UCP1-CreERT2 mice and characterized in this study. Efficient knockdown of CD47 in...
Source: Biochemical and Biophysical Research communications - July 27, 2023 Category: Biochemistry Authors: Dong Li Taesik Gwag Shuxia Wang Source Type: research
Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy
CONCLUSIONS: DRP1 is an essential factor in mitochondrial quality control during obesity cardiomyopathy that controls multiple forms of mitophagy. Although DRP1 regulates conventional mitophagy through a mitochondria-associated membrane-independent mechanism during the acute phase, it acts as a component of the mitophagy machinery at the mitochondria-associated membranes in alternative mitophagy during the chronic phase of HFD consumption.PMID:37232152 | DOI:10.1161/CIRCRESAHA.123.322512
Source: Circulation Research - May 26, 2023 Category: Cardiology Authors: Mingming Tong Risa Mukai Satvik Mareedu Peiyong Zhai Shin-Ichi Oka Chun-Yang Huang Chiao-Po Hsu Fawad A K Yousufzai Luke Fritzky Wataru Mizushima Gopal J Babu Junichi Sadoshima Source Type: research
