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Adherence to oral endocrine therapy in racial/ethnic minority patients with low socioeconomic status before and during the COVID-19 pandemic
CONCLUSION: OET adherence was significantly reduced during the COVID-19 pandemic in racial/ethnic minority patients with low SES. Patient-centered interventions are necessary to improve OET adherence in these patients.PMID:37380914 | DOI:10.1007/s11096-023-01609-6
Source: Clinical Genitourinary Cancer - June 28, 2023 Category: Cancer & Oncology Authors: Sama Rahimi Onyebuchi Ononogbu Anjana Mohan Daniel Moussa Susan Abughosh Meghana V Trivedi Source Type: research

Presidential reflections: how we got here, where we might go
Climacteric. 2023 Apr 3:1-9. doi: 10.1080/13697137.2023.2166823. Online ahead of print.ABSTRACTPieter van Keep was a founder and the third president of the International Menopause Society (IMS). He died, sadly, in 1991. Since then, every retiring president of the IMS has delivered the Pieter van Keep Memorial Lecture. This is an edited version of that lecture delivered at the 18th World Congress of the IMS in Lisbon, Portugal in 2022. In the article, President Steven R. Goldstein describes the path he followed that led him to the presidency of the IMS, including his original entry into transvaginal ultrasound, then gynecol...
Source: Climacteric - April 3, 2023 Category: Geriatrics Authors: S R Goldstein Source Type: research

Inhibition of Estrogen Receptor Signaling as a Strategy for Radiosensitization of ER+ Breast Cancers
CONCLUSION: Our data suggest that endocrine therapies may be effectively used to radiosensitize ER+ breast tumors. This work also supports further clinical investigation of the timing of RT for patients receiving ET as concurrent use may be more effective than sequential, especially as ET prior to RT is increasingly used as a bridging therapy during the COVID pandemic.PMID:34701020 | DOI:10.1016/j.ijrobp.2021.07.842
Source: Ann Oncol - October 27, 2021 Category: Cancer & Oncology Authors: A R Michmerhuizen A Pesch R Schwartz K Wilder-Romans M Liu A Harold R Azaria D Hayes J Rae L J Pierce C Speers Source Type: research

Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesis
Transgenic Res. 2021 Apr 14:1-13. doi: 10.1007/s11248-021-00249-8. Online ahead of print.ABSTRACTThe current coronavirus disease (COVID-19) pandemic remains one of the most serious public health problems. Increasing evidence shows that infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a very complex and multifaceted disease that requires detailed study. Nevertheless, experimental research on COVID-19 remains challenging due to the lack of appropriate animal models. Herein, we report novel humanized mice with Cre-dependent expression of hACE2, the main entry receptor of SARS-CoV-2. These mice ...
Source: Transgenic Research - April 15, 2021 Category: Genetics & Stem Cells Authors: Alexandra V Bruter Diana S Korshunova Marina V Kubekina Petr V Sergiev Anastasiia A Kalinina Leonid A Ilchuk Yuliya Yu Silaeva Eugenii N Korshunov Vladislav O Soldatov Alexey V Deykin Source Type: research

Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19
Cell Transplant. 2021 Jan-Dec;30:963689721991477. doi: 10.1177/0963689721991477.ABSTRACTTRANSLATIONAL RELEVANCE: No prophylactic treatments for COVID-19 have been clearly proven and found. In this pandemic context, cancer patients constitute a particularly fragile population that would benefit the best from such treatments, a present unmet need. TMPRSS2 is essential for COVID-19 replication cycle and it is under androgen control. Estrogen and androgen receptor dependent cues converge on TMPRSS2 regulation through different mechanisms of action that can be blocked by the use of hormonal therapies. We believe that there is e...
Source: Cell Transplantation - February 1, 2021 Category: Cytology Authors: Sara Bravaccini Eugenio Fonzi Michela Tebaldi Davide Angeli Giovanni Martinelli Fabio Nicolini Paola Parrella Massimiliano Mazza Source Type: research