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Drug: Dexamethasone

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Total 6562 results found since Jan 2013.

Positive programming of the GC-IGF1 axis mediates adult osteoporosis susceptibility in male offspring rats induced by prenatal dexamethasone exposure
In conclusion, PDE-induced intrauterine hypoglucocorticoid exposure could positively program IGF1 expression in bone tissue through the GRα/miR-130a-5p/HDAC4 pathways, thus mediating osteogenic dysdifferentiation and adult osteoporosis susceptibility in male offspring rats.PMID:36174767 | DOI:10.1016/j.bcp.2022.115264
Source: Biochemical Pharmacology - September 29, 2022 Category: Drugs & Pharmacology Authors: Yangfan Shangguan Xufeng Li Jun Qin Yinxian Wen Hui Wang Liaobin Chen Source Type: research

MiR-133a-3p/Sirt1 epigenetic programming mediates hypercholesterolemia susceptibility in female offspring induced by prenatal dexamethasone exposure
In conclusion, PDE can cause persistent enhancement of hepatic cholesterol synthesis function before and after birth through GR/miR-133a-3p/Sirt1 pathway, eventually leading to increased hypercholesterolemia susceptibility in female offspring rats.PMID:36326533 | DOI:10.1016/j.bcp.2022.115306
Source: Biochemical Pharmacology - November 3, 2022 Category: Drugs & Pharmacology Authors: Xufeng Li Wen Hu Li Li Ze Chen Tao Jiang Dingmei Zhang Kexin Liu Hui Wang Source Type: research

C-C motif chemokine ligand 2 promotes myogenesis of myoblasts via the AKT-mTOR pathway
In conclusion, CCL2 positively affects myogenesis by CCR2 via AKT-mTOR signaling pathways. CCL2 might have potential as a therapeutic target for low muscle mass and muscle recovery.PMID:36575043 | DOI:10.18632/aging.204451
Source: Aging - December 27, 2022 Category: Biomedical Science Authors: Mi Kyung Kwak Eun Suk Ha Jiwoo Lee Yun Mi Choi Beom-Jun Kim Eun-Gyoung Hong Source Type: research

Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer
CONCLUSIONS: There is insufficient evidence to support or refute the use of systemic corticosteroids in adults with cancer and CRF. We included four small studies that provided very low-certainty of evidence for the efficacy of corticosteroids in the management of CRF. Further high-quality randomised controlled trials with larger sample sizes are required to determine the effectiveness of corticosteroids in this setting.PMID:36688471 | PMC:PMC9869433 | DOI:10.1002/14651858.CD013782.pub2
Source: Cochrane Database of Systematic Reviews - January 23, 2023 Category: General Medicine Authors: Amy Sandford Alison Haywood Kirsty Rickett Phillip Good Sohil Khan Karyn Foster Janet R Hardy Source Type: research

Intratympanic corticosteroids for M énière's disease
CONCLUSIONS: The evidence for intratympanic corticosteroids in the treatment of Ménière's disease is uncertain. There are relatively few published RCTs, which all consider the same type of corticosteroid (dexamethasone). We also have concerns about publication bias in this area, with the identification of two large RCTs that remain unpublished. The evidence comparing intratympanic corticosteroids to placebo or no treatment is therefore all low- or very low-certainty. This means that we have very low confidence that the effects reported are accurate estimates of the true effect of these interventions. Consensus on the app...
Source: Cochrane Database of Systematic Reviews - February 27, 2023 Category: General Medicine Authors: Katie E Webster Ambrose Lee Kevin Galbraith Natasha A Harrington-Benton Owen Judd Diego Kaski Otto R Maarsingh Samuel MacKeith Jaydip Ray Vincent A Van Vugt Brian Westerberg Martin J Burton Source Type: research

National Utilization and Forecasting of Ototopical Antibiotics: Medicaid Data Versus “Dr. Google”
Objectives: To forecast national Medicaid prescription volumes for common ototopical antibiotics, and correlate prescription volumes with internet user search interest using Google Trends (GT). Study Design: National United States Medicaid prescription and GT user search database analysis. Methods: Quarterly national Medicaid summary drug utilization data and weekly GT search engine data for ciprofloxacin-dexamethasone (CD), ofloxacin (OF), and Cortisporin (CS) ototopicals were obtained from January 2008 to July 2014. Time series analysis was used to assess prescription seasonality, Holt–Winter's method for forecasting...
Source: Otology and Neurotology - August 13, 2016 Category: ENT & OMF Tags: Middle Ear and Mastoid Disease Source Type: research

Potential Dexamethasone-Direct Oral Anticoagulant Drug Interaction: Is This a Concern in COVID?
CONCLUSIONS: Concurrent use of dexamethasone and apixaban or rivaroxaban in hospitalized COVID-19 patients with laboratory evidence of COVID coagulopathy should be avoided until higher-quality data are available.PMID:34137279 | DOI:10.1177/10600280211025042
Source: The Annals of Pharmacotherapy - June 17, 2021 Category: Drugs & Pharmacology Authors: Maureen A Smythe Carly Burns Qianyue Liu Candice L Garwood Source Type: research

Systemic corticosteroids for the treatment of COVID-19
CONCLUSIONS: Moderate-certainty evidence shows that systemic corticosteroids probably slightly reduce all-cause mortality in people hospitalised because of symptomatic COVID-19. Low-certainty evidence suggests that there may also be a reduction in ventilator-free days. Since we are unable to adjust for the impact of early death on subsequent endpoints, the findings for ventilation outcomes and harms have limited applicability to inform treatment decisions. Currently, there is no evidence for asymptomatic or mild disease (non-hospitalised participants). There is an urgent need for good-quality evidence for specific subgroup...
Source: Cochrane Database of Systematic Reviews - August 16, 2021 Category: General Medicine Authors: Carina Wagner Mirko Griesel Agata Mikolajewska Anika Mueller Monika Nothacker Karoline Kley Maria-Inti Metzendorf Anna-Lena Fischer Marco Kopp Miriam Stegemann Nicole Skoetz Falk Fichtner Source Type: research

Pharmacotherapy for SARS-CoV-2 and Seizures for drug repurposing presumed on Mechanistic Targets
CONCLUSION: These findings would hopefully provide the basis for initiating further studies on the pathogenesis and drug targeting strategies for this emerging infection accompanied with seizures or in people with epilepsy.PMID:34645381 | DOI:10.2174/1874467214666211013122528
Source: Epilepsy Curr - October 14, 2021 Category: Neurology Authors: Divya Goel Ankit Srivastava Ángel Aledo-Serrano Anuja Krishnan Divya Vohora Source Type: research