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Drug: Dexamethasone

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Total 6562 results found since Jan 2013.

Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9
CONCLUSIONS: Salidroside protected against stretch-induced endothelial barrier function, improving lung injury after ventilation. Thus, salidroside may be a promising therapeutic agent for patients with MV-induced lung injury.PMID:34517742 | PMC:PMC8439245 | DOI:10.1080/13880209.2021.1967409
Source: Pharmaceutical Biology - September 14, 2021 Category: Drugs & Pharmacology Authors: Hui Zhang Wenwen Dong Siyuan Li Yunqian Zhang Zhou Lv Lu Yang Lai Jiang Tao Wu Yan Wang Source Type: research

ASAP Dual-Regulated Functionalized LiposomeNanoparticle Hybrids Loaded with Dexamethasone/TGF1-siRNA for Targeted Therapy of Glomerulonephritis
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c20053
Source: ACS Applied Materials and Interfaces - December 30, 2021 Category: Materials Science Authors: Pengchao Fang, Lu Han, Chunping Liu, Shichen Deng, E. Zhang, Puyang Gong, Yan Ren, Jian Gu, Lili He, and Zhi-xiang Yuan Source Type: research

FOXO3/TGF- β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells
AbstractThe transcription factor FOXO3 is necessary to preserve cochlear hair cells. Growth factors, including TGF- β, closely contribute to cochlear hair cell regeneration. In the present study, to investigate the roles of FOXO3 in the ciliogenesis and cell functions of cochlear hair cells, UB/OC-2 temperature-sensitive mouse cochlear precursor hair cells were treated with TGF-β receptor type 1 inhibitor EW-71 97 or EGF receptor inhibitor AG-1478 after transfection with or without siRNA-FOXO3a. GeneChip analysis revealed that treatment with EW-7197 increasedFoxo3 genes and decreased genes of Smads. During cell different...
Source: Histochemistry and Cell Biology - January 13, 2022 Category: Biomedical Science Source Type: research

SGK1 ‐targeted TRPV1 regulates bladder smooth muscle cell proliferation due to BOO in mice via NFAT2
ConclusionIn this study, SGK1 targeted TRPV1 to regulate the proliferation of MBSMCs mediated by BOO in mice through NFAT2 and then affected the process of bladder remodeling after BOO. This finding may provide a strategy for BOO drug target screening.This article is protected by copyright. All rights reserved.
Source: IUBMB Life - February 12, 2022 Category: Research Authors: Jiangshu He, Jin Yang, Lin Chen, Pinglin He, Xun Liu, Kai Wang, Taotao Dong, Jia Li, Xudong Ma, Amend Bastian, Stenzl Arnulf Tags: RESEARCH COMMUNICATION Source Type: research

Serum/glucocorticoid ‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activated T cell nuclear factor transcription factor 2
In this study, SGK1 targeted TRPV1 to regulate the proliferation of MBSMCs mediated by BOO in mice through NFAT2 and then affected the process of b ladder remodeling after BOO. This finding may provide a strategy for BOO drug target screening.
Source: IUBMB Life - February 21, 2022 Category: Research Authors: Jiangshu He, Jin Yang, Lin Chen, Pinglin He, Xun Liu, Kai Wang, Taotao Dong, Jia Li, Xudong Ma, Amend Bastian, Stenzl Arnulf Tags: RESEARCH COMMUNICATION Source Type: research

Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure
CONCLUSIONS: The currently available evidence on the effectiveness of adjunctive steroid therapy versus antibiotics alone in the management of acute endophthalmitis after intraocular surgery is inadequate. We found no studies that had enrolled cases of acute endophthalmitis following intravitreous injection. A combined analysis of two studies suggests that use of adjunctive steroids may provide a higher chance of having a good visual outcome at three months than not using adjunctive steroids. However, considering that most of the confidence intervals crossed the null, and that this review was limited in scope and applicabi...
Source: Cochrane Database of Systematic Reviews - June 6, 2022 Category: General Medicine Authors: Sara Emami Ken Kitayama Anne L Coleman Source Type: research

Dexamethasone Induces Apoptosis of Embryonic Palatal Mesenchymal Cells Through the GATA-6/Bone Morphogenetic Protein-2/p38 MAPK Pathway
Abstract: Exposure to dexamethasone (DEX) causes cleft palate at high rates. Our previous studies proved that GATA binding protein 6 (GATA-6)/bone morphogenetic protein-2 (BMP-2) mediated apoptosis is related to DEX-induced cleft palate, but the specific mechanism is still unclear. The goal of this research was to understand the mechanism of apoptosis in cleft palate formation induced by DEX. Palatal mesenchymal cells from mouse embryos on embryonic day 13 were isolated as the experimental group, GATA-6 was silenced by GATA-6 small interfering Ribonucleic Acid (RNA). Cell Counting Kit-8, flow cytometry and Western Blot...
Source: Journal of Craniofacial Surgery - July 1, 2022 Category: Surgery Tags: Original Articles Source Type: research

Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth
CONCLUSIONS: Overall, it remains unclear whether there are important differences between dexamethasone and betamethasone, or between one regimen and another. Most trials compared dexamethasone versus betamethasone. While for most infant and early childhood outcomes there may be no difference between these drugs, for several important outcomes for the mother, infant and child the evidence was inconclusive and did not rule out significant benefits or harms. The evidence on different antenatal corticosteroid regimens was sparse, and does not support the use of one particular corticosteroid regimen over another.PMID:35943347 |...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Myfanwy J Williams Jenny A Ramson Fiona C Brownfoot Source Type: research

Corticosteroid implants for chronic non-infectious uveitis
CONCLUSIONS: Our confidence is limited that local corticosteroid implants are superior to sham therapy or standard-of-care therapy in reducing the risk of uveitis recurrence. We demonstrated different effectiveness on BCVA relative to comparators in people with non-infectious uveitis. Nevertheless, the evidence suggests that these implants may increase the risk of cataract progression and IOP elevation, which will require interventions over time. To better understand the efficacy and safety profiles of corticosteroid implants, we need future trials that examine implants of different doses, used for different durations. The...
Source: Cochrane Database of Systematic Reviews - January 16, 2023 Category: General Medicine Authors: Amit Reddy Su-Hsun Liu Christopher J Brady Pamela C Sieving Alan G Palestine Source Type: research

BET 2: Dexamethasone for reduction of migraine recurrence
Report by: Andrew Neill, Registrar Emergency Medicine Search checked by: Domhnall Brannigan, Consultant Emergency Medicine Institution: St Vincent's University Hospital, Dublin, Ireland Abstract A short-cut review was carried out to establish whether the administration of dexamethasone reduced the risk of recurrence of migraine headaches at 24 h. Three hundred and fifteen articles were found using the reported search including two systematic reviews and meta-analyses. A total of nine trials was included between the two meta-analyses. One trial was included in both analyses from the abstract data but had subsequently b...
Source: Emergency Medicine Journal - January 24, 2013 Category: Emergency Medicine Tags: EMJ Best evidence topic reports, Headache (including migraine), Pain (neurology), Pregnancy Source Type: research

High-dose chemotherapy followed by autologous stem cell transplantation for patients with relapsed/refractory Hodgkin lymphoma.
CONCLUSIONS: The currently available evidence suggests a PFS benefit for patients with relapsed or refractory HL after first-line therapy, who are treated with HDCT followed by ASCT compared to patients treated with conventional chemotherapy. In addition, data showes a positive trend regarding OS, but more trials are needed to detect a significant effect.Intensifying the HDCT regime before HDCT followed by ASCT did not show a difference as compared to HDCT followed by ASCT, but was associated with increased adverse events. PMID: 23784872 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 20, 2013 Category: Journals (General) Authors: Rancea M, Monsef I, von Tresckow B, Engert A, Skoetz N Tags: Cochrane Database Syst Rev Source Type: research

WITHDRAWN: Serotonin receptor antagonists for highly emetogenic chemotherapy in adults.
CONCLUSIONS: Ondansetron and granisetron appear to be equivalent drugs for the prevention of acute and delayed emesis following the use of highly emetogenic chemotherapy.According to one single trial the combination of palonosetron and dexamethasone was superior to granisetron and dexamethasone in controlling delayed emesis. However, more evidence is needed before palonosetron could become the candidate 5-HT3 RA for the control of delayed emesis induced by highly emetogenic chemotherapy. PMID: 24323437 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 9, 2013 Category: Journals (General) Authors: Billio A, Morello E, Clarke MJ Tags: Cochrane Database Syst Rev Source Type: research