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Total 86 results found since Jan 2013.
Ectopic adrenocorticotrophic hormone syndrome secondary to treatment-related neuroendocrine differentiation of metastatic castrate-resistant prostate cancer
Endocrinol Diabetes Metab Case Rep. 2023 Jan 1;2023:22-0347. doi: 10.1530/EDM-22-0347. Online ahead of print.ABSTRACTSUMMARY: A 64-year-old man with progressive metastatic castrate-resistant prostate adenocarcinoma presented with recurrent fluid overload, severe hypokalaemia with metabolic alkalosis and loss of glycaemic control. Clinical features were facial plethora, skin bruising and proximal myopathy. Plasma adrenocorticotrophic hormone (ACTH), serum cortisol and 24-h urinary cortisol levels were elevated. Low-dose dexamethasone failed to suppress cortisol. Pituitary MRI was normal and 68Gallium-DOTATATE PET-CT scan sh...
Source: Cancer Control - January 10, 2023 Category: Cancer & Oncology Authors: Chelsea Tan Jessica Triay Source Type: research
Recurrent Cushing Syndrome From Metastatic Adrenocortical Carcinoma With Fumarate Hydratase Allelic Variant
CONCLUSION: Metastatic ACC presenting with severe CS presents a diagnostic and management challenge where combination therapy guided by a multidisciplinary team is essential. FH allelic variant may contribute to ACC progression.PMID:36447829 | PMC:PMC9701913 | DOI:10.1016/j.aace.2022.09.003
Source: Cancer Control - November 30, 2022 Category: Cancer & Oncology Authors: Emily Silverman Noor Addasi Muaataz Azzawi Ernesto Martinez Duarte Dali Huang Benjamin Swanson Apar Kishor Ganti Gwen Reiser Abbey L Fingeret Anupam Kotwal Source Type: research
No Adverse Effects on Periarticular Tissue by Intra-articular Vitamin D analogue Calcipotriol in a Reduced-Dose Zymosan-Induced Arthritis Model in Rats
Basic Clin Pharmacol Toxicol. 2022 Nov 18. doi: 10.1111/bcpt.13815. Online ahead of print.ABSTRACTCalcipotriol, a vitamin D analogue, is an antiproliferative and anti-inflammatory drug currently used in psoriasis. Here, our aim was to analyse the safety of calcipotriol for cartilage and bone in alleviated-dose (0.1mg instead of usual ≥1mg dose) zymosan-induced arthritis in rats. Theoretically, high doses of vitamin D or analogues could have detrimental effects on bone or cartilage. The rats were divided into four groups: vehicle (n=9), dexamethasone 0.1 mg/kg (n=9), calcipotriol 0.1 mg/kg (n=8) and negative control (n=10...
Source: Cancer Control - November 18, 2022 Category: Cancer & Oncology Authors: Jere Huovinen Jesse Lohela Sami Kauppinen Mikko Finnil ä Sakari Laaksonen Hanna-Marja Voipio Johanna A Huhtakangas Petri Lehenkari Source Type: research
A case report on non-metastatic Ewing sarcoma of the lumbar spine in a young patient
CONCLUSIONS: The presentation of lumbar ES can vary from local pain and swelling to acute paraparesis. Timely diagnosis and treatment with multimodal therapy, namely, steroids for acute spinal cord compression and surgery with chemoradiotherapy for ES can improve spinal biomechanics and oncological control.PMID:36193025 | DOI:10.1002/cnr2.1725
Source: Cancer Control - October 4, 2022 Category: Cancer & Oncology Authors: Shobha Mandal Srijana Baniya Dipesh Kumar Rohita Gopal Kumar Yadav Philip Lowry Source Type: research
MPN-092 Paraneoplastic Eosinophilia: An Unusual Initial Presentation of Metastatic Pancreatic Adenocarcinoma
We report the case of a 58-year-old female patient, a previously healthy heavy smoker who presented with worsening abdominal pain and dyspnea. Laboratory tests revealed hypereosinophilia with an absolute eosinophilic count (AEC) of 65,000/mm3, thrombocytosis (platelets=890,000/mm3), and disturbed liver function tests. Chest-abdomen-pelvis CT scan showed a huge necrotic tumor in the tail of the pancreas associated with multiple regional and retroperitoneal lymph nodes, liver metastases, and multiple bilateral lung nodules with lymphangitic carcinomatosis. We performed the following laboratory tests to exclude different etio...
Source: Clinical Lung Cancer - September 27, 2022 Category: Cancer & Oncology Authors: Tarek Badra Samer Nehme Omaya Baydoun Georges El Hachem Source Type: research
Mycoplasma Hominis: A Rare Case of Acute Otitis Media and Facial Nerve Paralysis
We report a case of AOM secondary to M. hominis, complicated by facial paralysis in an immunosuppressed patient. A 24-year-old male with multiple sclerosis, on rituximab, presented to the emergency department with otalgia and facial paralysis. He was diagnosed with Bell's palsy and subsequently referred to the otolaryngology service. Examination revealed right facial paralysis and purulent otorrhea. Computed tomography (CT) of the temporal bone showed right tympanic and mastoid opacification. The patient was admitted and started on IV ampicillin/sulbactam, IV dexamethasone, and ciprofloxacin/dexamethasone otic drops. Debri...
Source: Ear, Nose and Throat Journal - August 30, 2022 Category: ENT & OMF Authors: Birkaran Sadhar Ellen Ko-Keeney Rick Fornelli Sidney Lipman Source Type: research
Lansoprazole and zoledronate delays hard tissue healing of tooth extraction sockets in dexamethasone-treated mice
Biomed Pharmacother. 2022 Apr 21;150:112991. doi: 10.1016/j.biopha.2022.112991. Online ahead of print.ABSTRACTProton pump inhibitors (PPIs) are among the most commonly prescribed medicines for the management of acid-related gastrointestinal diseases. Osteonecrosis of the jaw (ONJ) is a serious adverse event that is associated with the use of antiresorptive and antiangiogenic agents. According to previous clinical reports, the use of PPIs contributes to the pathogenesis of severe ONJ that requires surgery. Here, we investigated the effects of lansoprazole (LP) or LP in combination with zoledronate (ZOL) on ONJ development i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 24, 2022 Category: Drugs & Pharmacology Authors: Reina Yoshioka Yuichi Mine Masato Kaku Hiroki Nikawa Takeshi Murayama Source Type: research
Bone Marrow Mesenchymal Stem Cells Overexpressing HIF-1 α Prevented the Progression of Glucocorticoid-Induced Avascular Osteonecrosis of Femoral Heads in Mice
Cell Transplant. 2022 Jan-Dec;31:9636897221082687. doi: 10.1177/09636897221082687.ABSTRACTGlucocorticoid (GC)-induced avascular osteonecrosis of femoral head (AOFH) is a devastating complication, and no cures are currently available for it. Previous studies have demonstrated that implantation of bone marrow mesenchymal stem cells (BMMSCs) may prevent the progression of pre-collapse AOFH. Based on previous observations, we hypothesized that GCs induce AOFH via the COX-2 (cyclooxygenase-2)-PGE-2 (prostaglandin E2)-HIF-1α (hypoxia-inducible factor-1α) axis, and that modification of BMMSCs may improve the efficacy of their i...
Source: Cell Transplantation - March 15, 2022 Category: Cytology Authors: Xin-Xin Zhang Xu Liang Sen-Rui Li Kuang-Jin Guo Dai-Feng Li Tian-Fang Li Source Type: research
Captopril alleviates glucocorticoid-induced osteonecrosis of the femoral head by mediating the ACE2/ Ang-(1-7)/Mas receptor cascade
This study investigated the therapeutic effects and potential mechanisms of the angiotensin-converting enzyme inhibitor (ACEI) captopril (CAP) in a rat model of glucocorticoid-induced femoral head necrosis (GIONFH). Bone marrow mesenchymal stem cells (mBMSC) from mice treated with dexamethasone (DEX) in vitro and methylprednisolone (MPS)-induced rats in vivo were used to explore the effects and mechanisms of CAP, respectively. Cell proliferation was detected in vitro by the CCK-8 assay, apoptosis by Annexin V-FITC-PI and Western blotting, and reactive oxygen species (ROS) by the DCFH-DA probe. Osteogenic ability was assess...
Source: European Journal of Pharmacology - March 14, 2022 Category: Drugs & Pharmacology Authors: Xiaohui Liu Yating Sun Qilu Wei Wuqiang Jiang Ming Jiao Junteng Yan Run Tian Pei Yang Kunzheng Wang Chunsheng Wang Source Type: research
A case of multiple sclerosis with protracted course of COVID-19
CONCLUSION: Although, most immunocompromised patients effectively clear SARS-CoV-2 infection, but this case report highlights the risk of persistent infection associated with recurrence of disease.PMID:35088680 | DOI:10.2174/1871526522666220128121855
Source: Infectious Disorders Drug Targets - January 28, 2022 Category: Infectious Diseases Authors: Mehrdad Hasibi Marjan Asadollahi Ali Asadollahi-Amin Source Type: research
