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Drug: Medroxyprogesterone
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Total 487 results found since Jan 2013.
Estrogen Inhibits Epithelial Progesterone Receptor-dependent Progestin Therapy Efficacy in a Mouse Model of Cervical Cancer
Am J Pathol. 2021 Nov 10:S0002-9440(21)00469-7. doi: 10.1016/j.ajpath.2021.10.008. Online ahead of print.ABSTRACTWhile the uterine cervix responds to the female sex hormone change, the role of progesterone in cervical cancer is poorly understood. It has been shown that medroxyprogesterone acetate (MPA) regresses cervical cancer in the transgenic mouse model expressing human papillomavirus type 16 (HPV16) E6 and E7 oncogenes. As MPA interacts most strongly with progesterone receptor (PR), we reasoned that PR would contribute to MPA-induced regression of cervical cancer. We also hypothesized that estrogen influences the ther...
Source: Am J Pathol - November 14, 2021 Category: Pathology Authors: Seunghan Baik Fabiola F Mehta Esra Unsal Yuri Park Sang-Hyuk Chung Source Type: research
Melatonin attenuates glucocorticoid effect induced by medroxyprogesterone acetate in rats
Gen Comp Endocrinol. 2021 Nov 30:113959. doi: 10.1016/j.ygcen.2021.113959. Online ahead of print.ABSTRACTMedroxyprogesterone acetate (MPA) acts on glucocorticoid receptors and, when it is in excess, can cause clinical disorders comparable to hyperadrenocorticism. Melatonin (MEL) is a hormone with potent antioxidant and anti-glucocorticoid activity and it can be beneficial in the excessive activation of glucocorticoid receptors. To evaluate the protective effects of MEL on the glucocorticoid effect of MPA, 34 male Wistar rats were randomized into four groups: CON (control), MEL, MPA, and MPA + MEL. The animals were treated ...
Source: General and Comparative Endocrinology - December 3, 2021 Category: Endocrinology Authors: Mariana Moreira Andraschko Mara Ta ís de Carvalho Hugo Cardoso Martins Pires Hellen Dorneles de Deus Carla Mart í Castelló Liliana Borges de Menezes Danieli Brolo Martins Marina Pacheco Miguel Source Type: research
Human chorionic gonadotropin affects original (ovulatory) and induced (accessory) corpora lutea, progesterone concentrations, and pregnancy rates in anestrous dairy goats
Reprod Biol. 2021 Dec 2;22(1):100591. doi: 10.1016/j.repbio.2021.100591. Online ahead of print.ABSTRACTTwo experiments were conducted in acyclic Alpine (A) and Saanen (S) goats that received intravaginal sponges containing 60 mg of medroxyprogesterone acetate for 6 days, as well as 200 IU of eCG and 30 μg d-cloprostenol i.m. 24 h before sponge removal. On day 7 (day 0 = onset of synchronized estrus), all goats were randomly divided into two groups: animals treated with 300 IU of hCG i.m. (hCG; Exp.1: n = 8A; Exp.2: n = 75A + S) and untreated controls (Control; Exp.1: n = 8A; Exp. 2: n = 70A + S). In Exp.2, all goats were ...
Source: Reproductive Biology - December 5, 2021 Category: Reproduction Medicine Authors: Juliana Nascimento Duarte Rodrigues Jos é Domingos Guimarães Maria Emilia Franco Oliveira Jenniffer Hauschildt Dias Aline Matos Arrais Marco Antonio Paula de Sousa Rosemary Bastos Bahareh Ahmadi Pawel Mieczyslaw Bartlewski Jeferson Ferreira Fonseca Source Type: research
Melatonin attenuates glucocorticoid effect induced by medroxyprogesterone acetate in rats
Gen Comp Endocrinol. 2021 Dec 1;316:113959. doi: 10.1016/j.ygcen.2021.113959. Online ahead of print.ABSTRACTMedroxyprogesterone acetate (MPA) acts on glucocorticoid receptors and, when it is in excess, can cause clinical disorders comparable to hyperadrenocorticism. Melatonin (MEL) is a hormone with potent antioxidant and anti-glucocorticoid activity and it can be beneficial in the excessive activation of glucocorticoid receptors. To evaluate the protective effects of MEL on the glucocorticoid effect of MPA, 34 male Wistar rats were randomized into four groups: CON (control), MEL, MPA, and MPA + MEL. The animals were treat...
Source: General and Comparative Endocrinology - December 3, 2021 Category: Endocrinology Authors: Mariana Moreira Andraschko Mara Ta ís de Carvalho Hugo Cardoso Martins Pires Hellen Dorneles de Deus Carla Mart í Castelló Liliana Borges de Menezes Danieli Brolo Martins Marina Pacheco Miguel Source Type: research
Incidence of herpes simplex virus type 2 infection among African women using depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a nested randomized trial
Clin Infect Dis. 2021 Dec 15:ciab1027. doi: 10.1093/cid/ciab1027. Online ahead of print.ABSTRACTBACKGROUND: Globally, women have higher herpes simplex type 2 (HSV-2) prevalence than men; data from observational studies suggest a possible association of HSV-2 acquisition with use of intramuscular depot medroxyprogesterone acetate (DMPA-IM).METHODS: Within a randomized trial of the effect of three contraceptive methods - DMPA-IM, a copper intrauterine device (IUD), and a levonorgestrel (LNG) implant - on HIV acquisition, we assessed HSV-2 acquisition. HSV-2 and HIV seronegative women, aged 16-35 years, and seeking effective ...
Source: Herpes - December 15, 2021 Category: Infectious Diseases Authors: Nelly R Mugo Randy M Stalter Renee Heffron Helen Rees Caitlin W Scoville Charles Morrison Athena P Kourtis Elizabeth Bukusi Mags Beksinka Neena M Philip Ivana Beesham Jen Deese Vinodh Edward Deborah Donnell Jared M Baeten Evidence for Contraceptive Option Source Type: research
Unique transcriptomic changes underlie hormonal interactions during mammary histomorphogenesis in female pigs
Endocrinology. 2021 Dec 16:bqab256. doi: 10.1210/endocr/bqab256. Online ahead of print.ABSTRACTSuccessful lactation and the risk for developing breast cancer depend on growth and differentiation of the mammary gland (MG) epithelium that is regulated by ovarian steroids (17beta-estradiol [E] and progesterone [P]) and pituitary-derived prolactin (PRL). Given that the MG of pigs share histomorphogenic features present in the normal human breast, we sought to define the transcriptional responses within the MG of pigs following exposure to all combinations of these hormones. Hormone-ablated female pigs were administered combina...
Source: Endocrinology - December 17, 2021 Category: Endocrinology Authors: Josephine F Trott Anke Schennink Katherine C Horigan Danielle G Lemay Julia R Cohen Thomas R Famula Julie A Dragon Russell C Hovey Source Type: research
