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Drug: Polyethylene Glycol

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Total 2716 results found since Jan 2013.

Reactive sulfur species inactivate Ca(2+)/calmodulin-dependent protein kinase IV via S -polysulfidation of its active-site cysteine residue.
Abstract Reactive sulfur species (RSS) modulate protein functions via S- polysulfidation of reactive Cys residues. Here, we report that Ca(2+)/calmodulin (CaM)-dependent protein kinase IV (CaMKIV) was reversibly inactivated by RSS via polysulfidation of the active site Cys residue. CaMKIV is phosphorylated at Thr(196) by its upstream CaMK kinase (CaMKK), resulting in the induction of its full activity. In vitro incubation of CaMKIV with the exogenous RSS donors Na2Sn ( n = 2-4) resulted in dose-dependent inhibition of the CaMKK-induced phospho-Thr(196) and consequent inactivation of the enzyme activity. Conversely...
Source: The Biochemical Journal - June 21, 2017 Category: Biochemistry Authors: Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y Tags: Biochem J Source Type: research

The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation
Publication date: Available online 4 March 2019Source: Nitric OxideAuthor(s): Tsuyoshi Takata, Ayaka Tsukuda, Yukihiro Tsuchiya, Takaaki Akaike, Yasuo WatanabeAbstractCa2+/calmodulin (CaM)-dependent protein kinase (CaMK) I is activated by the phosphorylation of a crucial activation loop Thr177 by upstream kinases, CaMK kinase (CaMKK), and regulates axonal or dendritic extension and branching. Reactive sulfur species (RSS) modulate protein functions via polysulfidation of the reactive Cys residues. Here, we report that the activity of CaMKI was reversibly inhibited via its polysulfidation at Cys179 by RSS. In vitro incubati...
Source: Nitric Oxide - March 5, 2019 Category: Chemistry Source Type: research

How the chain length of PEG functionalized at the outer surface of mesoporous silica nanoparticles alters the uptake of molecules?
New J. Chem. , 2016, Accepted Manuscript DOI : 10.1039/C6NJ01316C, Paper Leandro Carneiro Fonseca, Amauri Jardim de Paula, Diego Stefani Teodoro Martinez, Oswaldo Luiz Alves The current work describes the development of new mesoporous silica nanoparticles (MSNs) containing a high content of phenyl groups (hydrophobic species) inside the mesopores and externally functionalized with polyethylene glycol... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - July 29, 2016 Category: Chemistry Authors: Leandro Carneiro Fonseca Source Type: research

Noninferiority clinical trial comparing the bowel cleansing efficacy of sodium phosphate tablets (Quiklean < sup > ® < /sup > ) with a polyethylene glycol/bisacodyl kit
CONCLUSION: Quiklean® is sodium phosphate tablets available on Taiwan's market for bowel preparation; it potentially offers patients an alternative to standard large-volume bowel preparation regimens and may, therefore, increase positive attitudes toward colonoscopies and participation rates.PMID:33584074 | PMC:PMC7856840 | DOI:10.3748/wjg.v27.i5.428
Source: World Journal of Gastroenterology : WJG - February 15, 2021 Category: Gastroenterology Authors: Shih-Ya Hung Hung-Chang Chen Tao-Wei Ke Jiann-Hwa Chen Koung-Hung Hsiao Hwei-Ming Wang Hua-Che Chiang Sheng-Chi Chang Yi-Chang Chen Ming-Hao Hsieh Yuan-Yao Tsai Yo-Wen Hsieh William Tzu-Liang Chen Source Type: research

Polyethylene Glycol and Polysorbate Skin Testing in the Evaluation of COVID-19 Vaccine Reactions: Early Report
Ann Allergy Asthma Immunol. 2021 Mar 25:S1081-1206(21)00188-5. doi: 10.1016/j.anai.2021.03.012. Online ahead of print.NO ABSTRACTPMID:33775902 | PMC:PMC7997158 | DOI:10.1016/j.anai.2021.03.012
Source: Annals of Allergy, Asthma and Immunology - March 29, 2021 Category: Allergy & Immunology Authors: Mitchell M Pitlick Andrea N Sitek Susan A Kinate Avni Y Joshi Miguel A Park Source Type: research

Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions
This study aimed to formulate and optimize ALA using a self-nanoemulsifying drug delivery system (SNEDDS) with a size of nano-range, enhancing its absorption and augmenting its gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the pumpkin oil (X1, 10-30%), the surfactant tween 80 (X2, 20-50%), and the co-surfactant polyethylene glycol 200 (X3, 30-60%). The experimental design for the proposed mixture produced 16 formulations with varying ALA-SNEDDS formulation component percentages. The optimized ALA-SNEDDS formula was investigated for gastric ulcer protec...
Source: Dose Response - April 19, 2021 Category: Drugs & Pharmacology Authors: Shaimaa M Badr-Eldin Usama A Fahmy Hibah M Aldawsari Osama A A Ahmed Nabil A Alhakamy Solomon Z Okbazghi Mohamed A El-Moselhy Adel F Alghaith Aliaa Anter Asmaa I Matouk Wael Ali Mahdi Sultan Alshehri Rana Bakhaidar Source Type: research