• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Metformin and Aspirin: Anticancer effects on A549 and PC3 cancer cells and the mechanisms of action
This study aims to investigate the effect of metformin and aspirin and their combination of them on A549 and PC3 cell lines. Metformin and aspirin were investigated separately and in combination on two cancer cell lines, A549 and PC3. The examined groups include the negative control of untreated cells and the positive control of cisplatin and drugs at concentrations of 15, 10, and 20 μg/ mL to investigate the mechanism of oxidative stress factors (reactive oxygen species, lipid peroxidation, Glutathione (GSH)) and apoptosis (lactate dehydrogenase). The results showed that aspirin, metformin, and their combination could af...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Farzaneh Motafeghi Romina Shahsavari Parham Mortazavi Aysan Babaei Pouria SamadiMojaveri Omid Abed Khojasteh Mohammad Shokrzadeh Source Type: research

Data Democracy! ‘Dr. Google’ (2023) Vs. ‘Every Man His Own Physician’ (1767)
BY MICHAEL MILLENSON In the 18th-century, a pre-Google guide offered democratization of medical information In 1767, as American colonists’ protestations against “taxation without representation” intensified, a Boston publisher reprinted a book by a British doctor seemingly tailor-made for the growing spirit of independence. Talk about “democratization of health care information,” “participatory medicine” and “health citizens”! Every Man His Own Physician, by Dr. John Theobald, bore an impressive subtitle: Being a complete collection of efficacious and approved remedies for every disease...
Source: The Health Care Blog - July 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Democritization of Care Healthcare Michael Millenson Participatory medicine Source Type: blogs

Predictors of residual disease after debulking surgery in advanced stage ovarian cancer
CONCLUSIONS: Addition of ovarian tumor tissue markers to our multivariable prediction models based on epidemiologic/clinical data slightly improved the model performance, suggesting debulking status may be in part driven by tumor characteristics. Larger studies are warranted to identify those at high risk of poor surgical outcomes informing personalized treatment.PMID:36761962 | PMC:PMC9902593 | DOI:10.3389/fonc.2023.1090092
Source: Cancer Control - February 10, 2023 Category: Cancer & Oncology Authors: Farnoosh Abbas-Aghababazadeh Naoko Sasamoto Mary K Townsend Tianyi Huang Kathryn L Terry Allison F Vitonis Kevin M Elias Elizabeth M Poole Jonathan L Hecht Shelley S Tworoger Brooke L Fridley Source Type: research

"Vitreous Hemorrhage and Long-Lasting Priapism After COVID-19 m-RNA Based Vaccine: A Case Report"
CONCLUSIONS: Due to the several predisposing factors such as diabetes, aspirin assumption, history of blood dyscrasia and infectious retinitis, the relationship between the acute intraocular bleeding and the BNT162b2 inoculation remains difficult to ascertain in this patient. However, the occurrence of lasting priapism and vitreous hemorrhage within 24 h from the vaccination is a critical event which deserves to be mentioned.PMID:35505605 | DOI:10.1177/11206721221098880
Source: European Journal of Ophthalmology - May 4, 2022 Category: Opthalmology Authors: Barbara Casarini Francesco Bruni Pierangela Rubino Paolo Mora Source Type: research

Role of Combination Treatment of Aspirin and Zinc in DMH-DSS-induced Colon Inflammation, Oxidative Stress and Tumour Progression in Male BALB/c Mice
Biol Trace Elem Res. 2022 Apr 19. doi: 10.1007/s12011-022-03241-3. Online ahead of print.ABSTRACTColitis-associated colorectal cancer serves as a prototype of inflammation-associated cancers which is linked with repeated cycles of inflammation and DNA repair deficits. Several preclinical and clinical data reported that aspirin has a chemo-preventive effect in colorectal cancer and is associated with dose-dependent side effects. Furthermore, it has been reported that zinc supplementation improves the quality of life in patients undergoing chemotherapy by alteration of colonic cancer cell gene expression. However, explicatio...
Source: Cell Research - April 19, 2022 Category: Cytology Authors: Singothu Siva Nagendra Babu Shivani Singla Gopabandhu Jena Source Type: research

Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Safety, activity, and long-term outcomes of pomalidomide in the treatment of Kaposi sarcoma among individuals with or without HIV infection
CONCLUSIONS: Pomalidomide is a safe and active chemotherapy-sparing agent for the treatment of KS among individuals with or without HIV.PMID:34862247 | DOI:10.1158/1078-0432.CCR-21-3364
Source: Clinical Cancer Research - December 4, 2021 Category: Cancer & Oncology Authors: Ramya Ramaswami Mark N Polizzotto Kathryn Lurain Kathleen M Wyvill Anaida Widell Jomy George Priscila Goncalves Seth M Steinberg Denise Whitby Thomas S Uldrick Robert Yarchoan Source Type: research

Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities
Nutr Cancer. 2021 Jun 4:1-24. doi: 10.1080/01635581.2021.1934043. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a devastating disease. The standard first-line treatment for PDAC is gemcitabine chemotherapy which, unfortunately, offers only limited chance of a lasting cure. This review further evaluates the hypothesis that the effectiveness of gemcitabine can be improved by combining it with evidence-based complementary measures. Previously, supported by clinical trial data, we suggested that a number of dietary factors and nutraceuticals can be integrated with gemcitabine therapy. Here, we evalua...
Source: Nutrition and Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Mustafa B A Djamgoz Valerie Jentzsch Source Type: research

Pages: 1  2