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Drug: Aspirin
Nutrition: Vitamins
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Total 169 results found since Jan 2013.
Geriatric patient with neurological symptoms and prolonged aPTT
Inn Med (Heidelb). 2023 Sep 20. doi: 10.1007/s00108-023-01581-3. Online ahead of print.ABSTRACTA 73-year-old man with dementia was referred to our clinic with hypernatremia and volume depletion. New-onset neurogenic dysphagia was likely the reason for both. The patient had chronic embolic strokes on the computed tomography (CT) images. Documentation from previous hospitalizations in different hospitals revealed a repeatedly prolonged activated partial thromboplastin time (aPTT); 5 years prior, antiphospholipid antibody syndrome had already been suspected, but the necessary workup was never completed. We diagnosed the patie...
Source: Hamostaseologie - September 20, 2023 Category: Hematology Authors: Aisuluu Atakanova Anne Heiligers Martin Kirschner Cornelius Bollheimer Susanne Fleig Source Type: research
Targeting beta-catenin signaling for prevention of colorectal cancer - Nutraceutical, drug, and dietary options
Eur J Pharmacol. 2023 Jul 20:175898. doi: 10.1016/j.ejphar.2023.175898. Online ahead of print.ABSTRACTProgressive up-regulation of β-catenin signaling is very common in the transformation of colorectal epithelium to colorectal cancer (CRC). Practical measures for opposing such signaling hence have potential for preventing or slowing such transformation. cAMP/PKA activity in colon epithelium, as stimulated by COX-2-generated prostaglandins and β2-adrenergic signaling, boosts β-catenin activity, whereas cGMP/PKG signaling has the opposite effect. Bacterial generation of short-chain fatty acids (as supported by unrefined h...
Source: European Journal of Pharmacology - July 22, 2023 Category: Drugs & Pharmacology Authors: Simon Bernard Iloki Assanga Lidianys Mar ía Lewis Luján Mark F McCarty Source Type: research
Warfarin faring better: Vitamin K antagonists beat rivaroxaban and apixaban in the INVICTUS and PROACT Xa trials
J Thromb Haemost. 2023 Jul 8:S1538-7836(23)00523-8. doi: 10.1016/j.jtha.2023.06.036. Online ahead of print.ABSTRACTAlthough guidelines give preference to the direct oral anticoagulants (DOACs) over vitamin K antagonists (VKAs) for stroke prevention in most patients with atrial fibrillation (AF), DOACs are not recommended in those with rheumatic heart disease or mechanical heart valves. The results of the INVICTUS trial (Investigation of Rheumatic AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies), which compared rivaroxaban with a VKA in patients with rheumatic heart disease associated AF, and the PR...
Source: Thrombosis and Haemostasis - July 10, 2023 Category: Hematology Authors: John W Eikelboom Jeffrey I Weitz Source Type: research
Acute reperfusion treatment and secondary prevention of cancer-related stroke: comprehensive overview and proposal of clinical algorithm
In conclusion, acute CRS remains a clinical challenge, with many patients suffering recurrent stroke, despite preventive measures. More randomized-controlled clinical trials are urgently needed to pinpoint the most effective management options for this subset of stroke patients.PMID:37342814 | PMC:PMC10278431 | DOI:10.1177/17562864231180717
Source: Adv Data - June 21, 2023 Category: Epidemiology Authors: Athina-Maria Aloizou Lina Palaiodimou Dimitra Aloizou Efthimios Dardiotis Ralf Gold Georgios Tsivgoulis Christos Krogias Source Type: research
Safety outcomes of direct oral anticoagulants in older adults with atrial fibrillation: a systematic review and meta-analysis of (subgroup analyses from) randomized controlled trials
AbstractBalancing stroke prevention and risk of bleeding in patients with atrial fibrillation (AF) is challenging. Direct oral anticoagulants (DOACs) are by now considered standard of care for treating patients with AF in international guidelines. Our objective was to assess the safety of long-term intake of DOACs in older adults with AF. We included RCTs in elderly ( ≥ 65 years) patients with AF. A systematic search in MEDLINE and EMBASE was performed on 19 April 2022. For determination of risk of bias, the RoB 2 tool was applied. We pooled outcomes using random-effects meta-analyses. The quality of evidence was as...
Source: AGE - June 1, 2023 Category: Geriatrics Source Type: research
Chemoprevention of colorectal cancer in general population and high-risk population: a systematic review and network meta-analysis
CONCLUSIONS: Considering the balance between benefits and harms, regular use of coxibs for prevention of colorectal adenoma was not supported by the current evidence. Benefit of low-dose Asp for chemoprevention of colorectal adenoma still requires further evidence.REGISTRATION: PROSPERO, No. CRD42022296376.PMID:37027286 | DOI:10.1097/CM9.0000000000002514
Source: Chinese Medical Journal - April 7, 2023 Category: General Medicine Authors: Ye Ma Wen You Yang Cao Xuxia He Jing Wang Yuelun Zhang Ji Li Jingnan Li Source Type: research
Over-the-Counter Product-Apixaban Interactions: Patient Perspectives on Information-Seeking
CONCLUSIONS: Patients taking apixaban raised reasons for information-seeking about OTC products related to their perceptions of OTC products, provider-patient interactions, and their prior experiences with and frequency of OTC product use. Greater patient education about the need for information-seeking about potential DOAC-OTC product interactions may be needed at the time of prescribing.PMID:36972532 | DOI:10.1370/afm.21.s1.4239
Source: Annals of Family Medicine - March 27, 2023 Category: Primary Care Authors: Marley Magee Janice Schwartz Amanda McArthur Derjung Tarn Source Type: research
Labetalol, Low-dose Aspirin, and Vitamin E and Calcium for Gestational Hypertension and Influence on MicroRNA-126 and PLGF Levels
CONCLUSIONS: The combined therapy of labetalol + low-dose aspirin + vitamin E and calcium had a high efficacy rate and could significantly reduce blood pressure and 24h urine protein and significantly increase microRNA-126 and PLGF levels, with a high safety profile.PMID:36933245
Source: Alternative Therapies in Health and Medicine - March 18, 2023 Category: Complementary Medicine Authors: Xuejun Kou Jing Yang Source Type: research
