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Data Democracy! ‘Dr. Google’ (2023) Vs. ‘Every Man His Own Physician’ (1767)
BY MICHAEL MILLENSON
In the 18th-century, a pre-Google guide offered democratization of medical information
In 1767, as American colonists’ protestations against “taxation without representation” intensified, a Boston publisher reprinted a book by a British doctor seemingly tailor-made for the growing spirit of independence.
Talk about “democratization of health care information,” “participatory medicine” and “health citizens”! Every Man His Own Physician, by Dr. John Theobald, bore an impressive subtitle: Being a complete collection of efficacious and approved remedies for every disease...
Source: The Health Care Blog - July 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Democritization of Care Healthcare Michael Millenson Participatory medicine Source Type: blogs
Reversible 'Unstable' Abdominal Angina Caused by Ruptured Plaque of the Superior Mesenteric Artery: Clinical and Radiological Correlations
Eur J Case Rep Intern Med. 2023 Mar 30;10(4):003766. doi: 10.12890/2023_003766. eCollection 2023.ABSTRACTUnstable angina, characteristic of coronary artery disease, is caused by in-situ clot formation complicating ruptured atheromatous plaque. Abdominal angina, however, usually reflects chronic mesenteric ischaemia, caused by multi-vessel stable plaques involving mesenteric arteries. Herein, we describe a patient with new-onset abdominal pain caused by a ruptured atheromatous plaque at the superior mesenteric root. The diagnosis was based on an evident reversible epigastric bruit and high-degree eccentric stenosis caused b...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Shaul Yaari Nurith Hiller Yacov Samet Samuel N Heyman Source Type: research
Machine-learning-based prediction of pre-eclampsia using first-trimester maternal characteristics and biomarkers
CONCLUSIONS: Screening for PE using a non-linear machine-learning-based approach does not require a population-based normalization, and its performance is similar to that of logistic regression. Removing race information from the model reduces its prediction accuracy, especially for the non-white populations when only maternal factors are considered. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.PMID:36454636 | DOI:10.1002/uog.26105
Source: The Ultrasound Review of Obstetrics and Gynecology - December 1, 2022 Category: Radiology Authors: Z Ansbacher-Feldman A Syngelaki H Meiri R Cirkin K H Nicolaides Y Louzoun Source Type: research
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 11th 2022
In conclusion, plasma levels of IGHA2, APOA and HPT are associated with subclinical atherosclerosis independently of traditional risk factors and offers potential to predict this disease. The panel could improve primary prevention strategies in areas where imaging is not available.
A Lesser Diversity of Circulating Antibodies in the Aging Killifish Immune System
https://www.fightaging.org/archives/2022/04/a-lesser-diversity-of-circulating-antibodies-in-the-aging-killifish-immune-system/
Short-lived killifish are one of the more recently adopted animal models of aging. All such models are a trade-off betw...
Source: Fight Aging! - April 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Predicting Olfactory Loss In Chronic Rhinosinusitis Using Machine Learning
CONCLUSION: Olfactory dysfunction is a variable phenomenon in CRS patients. ML methods perform well compared to traditional logistic regression in classification of normosmia versus smell loss in CRS, and are able to include numerous risk factors into prediction models. Several actionable features were identified as risk factors for CRS-OD. These results suggest that ML methods may be useful for current understanding and future study of hyposmia secondary to sinonasal disease, the most common cause of persistent olfactory loss in the general population.PMID:34473227 | DOI:10.1093/chemse/bjab042
Source: Chemical Senses - September 2, 2021 Category: Biochemistry Authors: Vijay R Ramakrishnan Jaron Arbet Jess C Mace Krithika Suresh Stephanie Shintani Smith Zachary M Soler Timothy L Smith Source Type: research
Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models
Aging (Albany NY). 2021 Mar 5;13. doi: 10.18632/aging.202662. Online ahead of print.ABSTRACTExtracellular aggregation of the β-amyloid (Aβ) peptide into toxic multimers in the brain is a prominent event occurring in the pathogenesis of Alzheimer's disease (AD), and a large amount of Aβ in the blood is derived from platelets. Thus, we speculated that platelets may play an important role in the process of AD. We first investigated the changes in platelet Aβ secretion with age. Then, we injected platelets from aged amyloid precursor protein APP/PS1 mice into young C57 mice and assessed their memory capacity along with the...
Source: Aging - March 5, 2021 Category: Biomedical Science Authors: Tong Wu Lizhi Chen Lingqi Zhou Jie Xu Kaihua Guo Source Type: research
Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Repost: 63 minutes of ventricular fibrillation, followed by shock. What is going on?
In this study, 5% of VF arrest was due to PE: V fib is initial rhythm in PE in 3 of 60 cases. On the other hand, if the presenting rhythm is PEA, then pulmonary embolism is likely. When there is VF in PE, it is not the initial rhythm, but occurs after prolonged PEA renders the myocardium ischemic.--Another study by Courtney and Kline found that, of cases of arrest that had autopsy and found that a presenting rhythm of VF/VT had an odds ratio of 0.02 for massive pulmonary embolism as the etiology, vs 41.9 for PEA. ===================================MY Comment by KEN ...
Source: Dr. Smith's ECG Blog - June 27, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Exploring Nature ’s Treasure Trove of Helpful Compounds
A cone snail shell. Credit: Kerry Matz, University of Utah.
Over the years, scientists have discovered many compounds in nature that have led to the development of medications. For instance, the molecular structure for aspirin came from willow tree bark, and penicillin was found in a type of mold. And uses of natural products aren’t limited to medicine cabinet staples and antibiotics. A cancer drug was originally found in the bark of the Pacific yew tree, and a medication for chronic pain relief was first isolated from cone snail venom. Today, NIGMS supports scientists in the earliest stages of investigating natural pro...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 24, 2020 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Bacteria Cool Tools/Techniques Medicines Microbes Source Type: blogs
Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation.
Lin28 as a Target for Nerve Regeneration
https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/
Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pandemic Fears: What the AIDS Battle Should Teach Us About COVID-19
By ANISH KOKA, MD
As the globe faces a novel, highly transmissible,
lethal virus, I am most struck by a medicine cabinet that is embarrassingly
empty for doctors in this battle. This
means much of the debate centers on mitigation of spread of the virus. Tempers flare over discussions on travel
bans, social distancing, and self quarantines, yet the inescapable fact remains
that the medical community can do little more than support the varying
fractions of patients who progress from mild to severe and life threatening
disease. This isn’t meant to minimize the
massive efforts brought to bear to keep pat...
Source: The Health Care Blog - March 12, 2020 Category: Consumer Health News Authors: Christina Liu Tags: CORVID-19 Health Policy Patients Physicians AIDS Anish Koka AZT coronavirus COVID-19 FDA novel coronavirus Pandemic Source Type: blogs
MKSAP: 67-year-old man with a carotid bruit
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 67-year-old man is evaluated for a carotid bruit detected on routine medical examination. He reports no history of previous focal neurologic symptoms or visual loss. He has type 2 diabetes mellitus and hyperlipidemia treat ed with metformin, moderate-intensity pravastatin, and aspirin. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - November 23, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Cardiology Source Type: blogs
The new aspirin guidelines: The media does a disservice to patients
Much media attention has been paid to the new guidelines from American College of Cardiology/American Heart Association (ACC/AHA) on the primary prevention of cardiovascular disease. Based on new clinical trial data, ACC/AHA no longer recommends that healthy adults without cardiovascular disease— emphasis on without cardiovascular disease— take daily aspirin for the primary prevention […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - May 13, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/olubadewa-a-fatunde" rel="tag" > Olubadewa A. Fatunde, MD, MPH < /a > < /span > Tags: Meds Cardiology Mainstream media Source Type: blogs
