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Drug: Nifedipine
Nutrition: Calcium

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Total 50 results found since Jan 2013.

Hypocalcemic tetany associated with simultaneous administration of cimetidine and nifedipine: a case report
ConclusionsSevere hypocalcemic tetany can occur with concomitant administration of cimetidine and nifedipine. Immediate treatment with calcium gluconate quickly reverses this adverse event. Concomitant administration of these drugs should be done with caution or be avoided if possible.
Source: Journal of Medical Case Reports - July 28, 2023 Category: General Medicine Source Type: research

Vasodilators For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion In summary, vasodilators play a pivotal role in managing cardiovascular conditions, including hypertension, which is rapidly becoming a global health concern. By expanding the body’s blood vessels, these unique medications can improve blood flow and decrease the pressure exerted by the heart, thereby providing relief to numerous patients worldwide. Their applications are diverse, extending beyond hypertension to conditions like angina, heart failure, and even erectile dysfunction. However, these medications should be taken carefully and always under the supervision of a doctor due to the potent...
Source: The EMT Spot - July 27, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Calcium-Channel Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion In a nutshell, calcium-channel blockers are a valuable tool in the medical arsenal for treating a range of cardiovascular conditions. By inhibiting calcium’s entry into the heart and blood vessel cells, these drugs induce blood vessel dilation and relaxation, reducing blood pressure. Their unique properties and effectiveness make them especially suitable for groups like older adults and people of African descent, and those with conditions like angina, certain arrhythmias, and Raynaud’s disease. Even with the possibility of side effects and drug interactions, calcium-channel blockers are g...
Source: The EMT Spot - July 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

A Pilot, Prospective, Randomized-Controlled Study to Evaluate the Efficacy and Safety of Arsha Hita ™ in the Treatment of Anal Fissures
Conclusion The pilot study provides evidence that the combination of Arsha Hita tablets and Arsha Hita ointment may be more effective and safer for treating anal fissures than the standard treatment. The test treatment group experienced greater pain relief, complete resolution of per-anal bleeding, and better global impression scores than the standard treatment group. These findings suggest the need for further research through larger, randomized controlled trials to determine the efficacy and safety of Arsha Hita in treating anal fissures.PMID:37193430 | PMC:PMC10182782 | DOI:10.7759/cureus.37531
Source: Pain Physician - May 16, 2023 Category: Anesthesiology Authors: Gopikrishna B J Sahanasheela K R Suhas K Shetty Prasanna N Rao Sangam Narvekar Megha Nalawade Mukesh B Chawda Kruttika R Chitnis Rajmohan Seetharaman Raakhi K Tripathi Source Type: research

Voltage-gated calcium currents in human dorsal root ganglion neurons
Voltage-gated calcium channels in sensory neurons underlie processes ranging from neurotransmitter release to gene expression and remain a therapeutic target for the treatment of pain. Yet virtually all we know about voltage-gated calcium channels has been obtained through the study of rodent sensory neurons and heterologously expressed channels. To address this, high voltage–activated (HVA) Ca2+ currents in dissociated human and rat dorsal root ganglion neurons were characterized with whole-cell patch clamp techniques. The HVA currents from both species shared basic biophysical and pharmacological properties. However, H...
Source: Pain - May 19, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

Nifedipine for primary dysmenorrhoea
CONCLUSIONS: The evidence is insufficient to confirm whether nifedipine is a possible medical treatment for primary dysmenorrhoea. The trials included in this review had very low numbers and were of low quality. Notably, there was a large imbalance in numbers randomised between placebo and treatment groups in one of the two trials with data available for analysis. While there was no evidence of a difference noted in adverse effects between groups, more data from larger participant numbers are needed for this outcome. Larger, more well-conducted trials are required to elucidate the potential role of nifedipine in the treatm...
Source: Cochrane Database of Systematic Reviews - December 18, 2021 Category: General Medicine Authors: Rachel A Earl Rosalie M Grivell Source Type: research

Drug-induced gingival overgrowth in cardiovascular patients
World J Cardiol. 2021 Apr 26;13(4):68-75. doi: 10.4330/wjc.v13.i4.68.ABSTRACTDrug-induced gingival overgrowth (DIGO) is a pathological growth of gingival tissue, primarily associated with calcium channel blockers and immunosuppressants. Consequently, it is mainly seen in cardiovascular and transplanted patients. Nifedipine remains the main calcium channel blocker related to the development of this unpleasant side-effect. As for immunosuppressants, cyclosporin is the leading causative agent, whereas other drugs from this drug-group, including tacrolimus, have better safety profiles. Accumulated collagen with inflammatory in...
Source: World Journal of Cardiology - May 10, 2021 Category: Cardiology Authors: Lucija Bajkovec Anna Mrzljak Robert Likic Ivan Alajbeg Source Type: research