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Hazard identification and risk assessment of the organic, inorganic and microbial contaminants in the surface water after the high magnitude of flood event
Environ Int. 2021 Sep 21;157:106851. doi: 10.1016/j.envint.2021.106851. Online ahead of print.ABSTRACTThe present work has been oriented to the qualitative and quantitative assessments of the aftermath effects of 2014 flood tragedy on the organic, inorganic and microbial contaminants in the floodwater, with a particular emphasis on their relative health risks and microbial infectious hazards to the flood-affected population, using average daily dose, hazard quotient, hazard index (HI), cancer risk (CR) and quantitative microbial risk assessment. Statistical comparison of the organic and inorganic contents was performed usi...
Source: Environment International - September 24, 2021 Category: Environmental Health Authors: Kah Yee Lim Keng Yuen Foo Source Type: research

Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse
In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or ...
Source: Frontiers in cellular and infection microbiology - May 1, 2019 Category: Microbiology Source Type: research

A Novel lncRNA Regulates the Toll-Like Receptor Signaling Pathway and Related Immune Function by Stabilizing FOS mRNA as a Competitive Endogenous RNA
In conclusion, our study shows that the novel lncRNA- XLOC_098131 plays a key role in the molecular mechanism underlying the immune function mediated by DA. This study provides new insight into the molecular mechanisms through which DA affects the Toll-like receptor signaling pathway-related immune response and the mechanisms through which lncRNAs regulate mRNA expression. As direct target genes, miR-548s plays important roles in mediating the regulation of FOS by the lncRNA- XLOC_098131 to affect immunity. These data constitute high-quality resources for future genome and functional research. Ethics Statement The experi...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Human Health Effects of Dichloromethane: Key Findings and Scientific Issues
Conclusion: The 2011 IRIS assessment of dichloromethane provides insights into the toxicity of a commonly used solvent. Citation: Schlosser PM, Bale AS, Gibbons CF, Wilkins A, Cooper GS. 2015. Human health effects of dichloromethane: key findings and scientific issues. Environ Health Perspect 123:114–119; http://dx.doi.org/10.1289/ehp.1308030 Address correspondence to G.S. Cooper, National Center for Environmental Assessment (8601-P), U.S. Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460 USA. Telephone: (703) 347-8636. E-mail: Cooper.Glinda@epa.gov The views expressed are thos...
Source: EHP Research - February 2, 2015 Category: Environmental Health Authors: Web Admin Tags: Commentary February 2015 Source Type: research