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Drug: Estradiol
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Total 16 results found since Jan 2013.
Effects of sleep fragmentation and estradiol decline on cortisol in a human experimental model of menopause
CONCLUSIONS: Both estradiol suppression and modifiable menopause-related sleep fragmentation independently perturb HPA axis activity. Sleep fragmentation, commonly seen in menopausal women, may disrupt the HPA axis, which in turn may lead to adverse health effects as women age.PMID:37207451 | DOI:10.1210/clinem/dgad285
Source: The Journal of Clinical Endocrinology and Metabolism - May 19, 2023 Category: Endocrinology Authors: Aviva Y Cohn Leilah K Grant Margo D Nathan Aleta Wiley Mathena Abramson Jessica A Harder Sybil Crawford Elizabeth B Klerman Frank A J L Scheer Ursula B Kaiser Shadab A Rahman Hadine Joffe Source Type: research
Ovarian status modulates endocrine and neuroinflammatory responses to a murine mammary tumor
Am J Physiol Regul Integr Comp Physiol. 2022 Aug 22. doi: 10.1152/ajpregu.00124.2022. Online ahead of print.ABSTRACTBreast cancer patients have increased circulating inflammatory markers and mammary tumors increase neuroinflammation in rodent models. Menopausal status is not only important in the context of breast cancer as circulating estrogen influences tumor progression, but also because estrogen is anti-inflammatory and an essential modulator of endocrine function in the brain and body. Here, we manipulated "menopause" status (ovary-intact and ovariectomized) in an ER+ mouse mammary tumor model to determine the extent ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 22, 2022 Category: Physiology Authors: Lindsay D Strehle Kathryn L G Russart Valerie A Burch Corena V Grant Leah M Pyter Source Type: research
Sleep fragmentation and estradiol suppression decrease fat oxidation in pre-menopausal women
CONCLUSIONS: Sleep fragmentation and hypoestrogenism each independently alter fasting substrate oxidation in a manner that may contribute to body fat gain. These findings are important for understanding mechanisms underlying propensity to body fat gain in women across the menopause transition.PMID:35569055 | DOI:10.1210/clinem/dgac313
Source: The Journal of Clinical Endocrinology and Metabolism - May 15, 2022 Category: Endocrinology Authors: Leilah K Grant Jamie E Coborn Aviva Cohn Margo D Nathan Frank A J L Scheer Elizabeth B Klerman Ursula B Kaiser Jessica Harder Mathena Abramson Elkhansaa Elguenaoui Julia A Russell Aleta Wiley Shadab A Rahman Hadine Joffe Source Type: research
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
17 {beta}-Estradiol promotes vascular endothelial growth factor expression via the Wnt/{beta}-catenin pathway during the pathogenesis of endometriosis
STUDY HYPOTHESIS
Do estrogen and Wnt/β-catenin signaling promote vascular endothelial growth factor (VEGF) expression in endometriosis and how?
STUDY FINDING
17β-Estradiol (E2)-drives β-catenin triggered up-regulation of VEGF in effector human primary endometrial stromal cells (ESCs) and thus enhances their ability to establish a new blood supply to the human exfoliated endometrium.
WHAT IS KNOWN ALREADY
Implantation and survival of exfoliated endometrium is crucially dependent on neovascularization and Wnt/β-catenin signaling plays an important role in stimulating angiogenesis.
STUDY DESIGN, SAMPLES...
Source: Molecular Human Reproduction - July 11, 2016 Category: Molecular Biology Authors: Zhang, L., Xiong, W., Xiong, Y., Liu, H., Liu, Y. Tags: Original Research Source Type: research
Id: 85: cross-talk between estrogen receptors and insulin-like growth factor type-1 receptor modulates human prostate stem/progenitor cell amplification
We previously demonstrated that estrogen regulates human prostate stem/progenitor cell amplification by directly targeting estrogen receptors (ERs); ERα stimulates whereas ERβ suppresses stem cell self-renewal. In addition to ERα and ERβ, we find that human prostate stem/progenitor cells express robust level of IGF-1R. Since ER actions can be modified by IGF-1R through ligand-independent ER phosphorylation, we herein sought to characterize potential cross-talk between estrogen and IGF-1 signaling pathways in regulating human prostate stem/progenitor cell amplification. Human prostate stem/progenitor c...
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Rinaldi, J., Hu, W., Majundar, S., Hu, D., Prins, G., Justulin, L., Felisbino, S. Tags: Endocrinology/Metabolism Source Type: research
The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health
Conclusion: SRP must continue to address the legacy of hazardous waste in the United States, respond to new issues caused by rapid advances in technology, and train the next generation of leaders in environmental health science while recognizing that most of the world’s worst toxic hot spots are now located in low- and middle-income countries.
Citation: Landrigan PJ, Wright RO, Cordero JF, Eaton DL, Goldstein BD, Hennig B, Maier RM, Ozonoff DM, Smith MT, Tukey RH. 2015. The NIEHS Superfund Research Program: 25 years of translational research for public health. Environ Health Perspect 123:909–918; http:/...
Source: EHP Research - September 30, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Commentary October 2015 Source Type: research
