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Drug: Metformin
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Total 6410 results found since Jan 2013.
Prevention and treatment of antipsychotic induced weight gain
CONCLUSION: In the revision of the Dutch multidisciplinary guideline for schizophrenia, the detection, prevention, and treatment of AIWG deserves more attention.PMID:37323046
Source: Tijdschrift voor Psychiatrie - June 16, 2023 Category: Psychiatry Authors: S R T Veerman D Cohen Source Type: research
The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Metformin should be considered as an efficacious adjunct to lifestyle interventions in adults with PCOS, especially for those with a higher BMI, to improve weight loss, insulin resistance and lipids.PMID:37536294 | DOI:10.1093/ejendo/lvad098
Source: European Journal of Endocrinology - August 3, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research
Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins
Biomed Pharmacother. 2023 Aug 1;165:115263. doi: 10.1016/j.biopha.2023.115263. Online ahead of print.ABSTRACTIn addition to the anti-diabetic effect of metformin, a growing number of studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which have potent, that can treat other disorders other than diabetes mellitus. We aimed to describe and review the protective and antidotal efficacy of metformin against biologicals, chemicals, natural, medications, pesticides, and radiation-induced toxicities. A comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2023 Category: Drugs & Pharmacology Authors: Amirhossein Malaekeh-Nikouei Sina Shokri-Naei Sobhan Karbasforoushan Hossein Bahari Vafa Baradaran Rahimi Reza Heidari Vahid Reza Askari Source Type: research
The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Metformin should be considered as an efficacious adjunct to lifestyle interventions in adults with PCOS, especially for those with a higher BMI, to improve weight loss, insulin resistance and lipids.PMID:37536294 | DOI:10.1093/ejendo/lvad098
Source: European Journal of Endocrinology - August 3, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research
Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins
Biomed Pharmacother. 2023 Aug 1;165:115263. doi: 10.1016/j.biopha.2023.115263. Online ahead of print.ABSTRACTIn addition to the anti-diabetic effect of metformin, a growing number of studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which have potent, that can treat other disorders other than diabetes mellitus. We aimed to describe and review the protective and antidotal efficacy of metformin against biologicals, chemicals, natural, medications, pesticides, and radiation-induced toxicities. A comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2023 Category: Drugs & Pharmacology Authors: Amirhossein Malaekeh-Nikouei Sina Shokri-Naei Sobhan Karbasforoushan Hossein Bahari Vafa Baradaran Rahimi Reza Heidari Vahid Reza Askari Source Type: research
Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis
CONCLUSIONS: The choice of metformin or COCP treatment should be based on symptoms, noting that there are some biochemical benefits from combination treatment, targeting both major endocrine disturbances seen in PCOS; hyperinsulinemia and hyperandrogenism.PMID:37554096 | DOI:10.1210/clinem/dgad465
Source: The Journal of Clinical Endocrinology and Metabolism - August 9, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research
Novel pharmacological approaches in abdominal aortic aneurysm
Clin Sci (Lond). 2023 Aug 14;137(15):1167-1194. doi: 10.1042/CS20220795.ABSTRACTAbdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, boosted by atherosclerosis, ageing, and smoking as major risk factors. Aneurysm growth increases the risk of aortic rupture, a life-threatening emergency with high mortality rates. Despite the increasing progress in our knowledge about the etiopathology of AAA, an effective pharmacological treatment against this disorder remains elusive and...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: L ídia Puertas-Umbert Rafael Almendra-Pegueros Francesc Jim énez-Altayó Marc Sirvent Mar ía Galán Jos é Martínez-González Cristina Rodr íguez Source Type: research
Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis
CONCLUSIONS: The choice of metformin or COCP treatment should be based on symptoms, noting that there are some biochemical benefits from combination treatment, targeting both major endocrine disturbances seen in PCOS; hyperinsulinemia and hyperandrogenism.PMID:37554096 | DOI:10.1210/clinem/dgad465
Source: The Journal of Clinical Endocrinology and Metabolism - August 9, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research
SPIOMET4HEALTH —efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, fo ur-arm, parallel-group, phase II clinical trial
DiscussionThe present study will be the first to evaluate —in a randomised, double-blind, placebo-controlled way—the efficacy, tolerability and safety of SPIOMET treatment for early PCOS, on top of a lifestyle intervention.Trial registrationEudraCT 2021 –003177-58. Registered on 22 December 2021.https://www.clinicaltrialsregister.eu/ctr-search/search?query=%092021-003177-58.
Source: Trials - September 15, 2023 Category: Research Source Type: clinical trials
