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Drug: Metformin
Nutrition: Sugar
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Total 63 results found since Jan 2013.
GAL3 Mediates Vascular Dysfunction in Obesity by Regulating NOX1
CONCLUSIONS: Deletion of GAL3 normalizes microvascular endothelial function in obese db/db mice, likely through an NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.PMID:37586054 | DOI:10.1161/ATVBAHA.123.319476
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 16, 2023 Category: Cardiology Authors: Caleb A Padgett R óbert K Bátori Andrew C Speese Cody L Rosewater Weston B Bush Cassandra C Derella Stephen B Haigh Hunter G Sellers Zachary L Corley Madison A West James D Mintz Brittany B Ange Ryan A Harris Michael W Brands David J R Fulton David W St Source Type: research
Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins
Biomed Pharmacother. 2023 Aug 1;165:115263. doi: 10.1016/j.biopha.2023.115263. Online ahead of print.ABSTRACTIn addition to the anti-diabetic effect of metformin, a growing number of studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which have potent, that can treat other disorders other than diabetes mellitus. We aimed to describe and review the protective and antidotal efficacy of metformin against biologicals, chemicals, natural, medications, pesticides, and radiation-induced toxicities. A comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2023 Category: Drugs & Pharmacology Authors: Amirhossein Malaekeh-Nikouei Sina Shokri-Naei Sobhan Karbasforoushan Hossein Bahari Vafa Baradaran Rahimi Reza Heidari Vahid Reza Askari Source Type: research
Do DPP-4 enzyme inhibitors affect hemoglobin, leucocyte and thrombocyte levels in patients with type 2 diabetes mellitus?
CONCLUSIONS: Abnormalities in hemogram parameters in type 2 DM patients using DPP-4 enzyme inhibitors should not be immediately related to DPP-4 enzyme inhibitors, and non-drug etiologies that may cause abnormal levels in hemogram parameters should be carefully investigated.PMID:37259744 | DOI:10.26355/eurrev_202305_32470
Source: Pharmacological Reviews - June 1, 2023 Category: Drugs & Pharmacology Authors: F Avc ı Merdin A Merdin Source Type: research
Metformin adherence and the risk of cardiovascular disease: a population-based cohort study
CONCLUSIONS: This study revealed that metformin adherence in patients with T2DM who required a first-line treatment may reduce the risk of subsequent CVD. Despite the availability of numerous novel antiglycemic agents, metformin adherence by patients who require a combination of antiglycemic agents provides an additional benefit of CVD protection.PMID:37051071 | PMC:PMC10084537 | DOI:10.1177/20406223231163115
Source: Adv Data - April 13, 2023 Category: Epidemiology Authors: Shun-Fan Yu Chien-Tai Hong Wan-Ting Chen Lung Chan Li-Nien Chien Source Type: research
Entering the sugar rush era: revisiting the antihyperglycemic activities of biguanides after a century of metformin discovery
Curr Med Chem. 2022 Aug 20. doi: 10.2174/0929867329666220820151959. Online ahead of print.ABSTRACTThe development of clinically viable metformin analogs is a challenge largely to be overcome. Despite being an extremely efficient drug for the treatment of type 2 diabetes mellitus, multiple studies were conducted seeking to improve its hypoglycemic activity or to ameliorate aspects such as the low oral absorption and the incidence of gastrointestinal side effects. Furthermore, efforts have been made to attribute new activities, or even to expand the pre-existing ones, that could enhance its effects in the diabetes, such as p...
Source: Current Medicinal Chemistry - August 23, 2022 Category: Chemistry Authors: Xisto Antonio de Oliveira Neto Leticia Barssotti Ana Thereza Fiori-Duarte Helena Cristina de Lima Barbosa Daniel F ábio Kawano Source Type: research
Comparison of neonatal and maternal outcomes of anti-diabetic drugs in the treatment of gestational diabetes mellitus: Findings from Bayesian network meta-analysis
J Family Med Prim Care. 2022 May;11(5):1610-1618. doi: 10.4103/jfmpc.jfmpc_1319_21. Epub 2022 May 14.ABSTRACTThe safety and efficacy of different anti-diabetic drugs are not clear because of the lack of sufficiently powered clinical trials. This network meta-analysis was conducted to compare the efficacy and safety of three anti-diabetic drugs (insulin, glyburide, and metformin), and rank them as per their efficiency to control glucose levels, pregnancy, and neonatal outcomes. The study design is a systematic review, meta-analysis, and network meta-analysis. After a systematic search of existing databases, 34 randomized co...
Source: Primary Care - July 8, 2022 Category: Primary Care Authors: Mandar K Shah Mihika A Shah Sharan D Shah Parshwa K Shah Kaushal Patel Mamta Gupta Source Type: research
