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Drug: Metformin
Nutrition: Calcium
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Total 76 results found since Jan 2013.
Injectable periodontal ligament stem cell-metformin-calcium phosphate scaffold for bone regeneration and vascularization in rats
CONCLUSIONS: The novel injectable construct with hPDLSC and Met encapsulation demonstrated excellent efficacy for bone regeneration and vascularization in vivo in an animal model. CPC+hPDLSCs+ 0.1%Met is highly promising for dental and craniofacial applications.PMID:37574338 | DOI:10.1016/j.dental.2023.07.008
Source: Cancer Control - August 13, 2023 Category: Cancer & Oncology Authors: Yaxi Sun Zeqing Zhao Qingchen Qiao Shengnan Li Wenting Yu Xiuchen Guan Abraham Schneider Michael D Weir Hockin H K Xu Ke Zhang Yuxing Bai Source Type: research
Primary Hyperparathyroidism overlapping with Multiple Sclerosis: a catastrophic marriage
Acta Biomed. 2023 Jul 24;94(S1):e2023128. doi: 10.23750/abm.v94iS1.14446.ABSTRACTPrimary hyperparathyroidism (PHPT) often leads to neurological or psychiatric disorders, thus mimicking different diseases. Here we present a 77-years old man visited in the Emergency Department complaining for fatigue, multiple falls, nausea, anorexia, and constipation. Symptoms were rapidly worsening, and on admission he appeared sleepy, responsive to verbal stimulus, disoriented, dehydrated, unable to maintain upright position. He suffered from mild, relapsing and remitting Multiple Sclerosis (MS) since the age of 45, at that moment not req...
Source: Acta Bio-Medica : Atenei Parmensis - July 24, 2023 Category: General Medicine Authors: Gianfranco Cervellin Vincenzo Brianti Lorenzo Viani Lucia Feldmann Gianni Rastelli Source Type: research
Administration of metformin rescues age-related vulnerability to ischemic insults through mitochondrial energy metabolism
Biochem Biophys Res Commun. 2023 Apr 5;659:46-53. doi: 10.1016/j.bbrc.2023.04.004. Online ahead of print.ABSTRACTIschemic heart disease (IHD) is the leading cause of death on a global scale. Despite significant advances in the reperfusion treatment of acute myocardial infarction, there is still a significant early mortality rate among the elderly, as angioplasty-achieved reperfusion can exacerbate myocardial damage, leading to severe ischemia/reperfusion (I/R) injury and induce fatal arrhythmias. Mitochondria are a key mediator of ischemic insults; a transient blockade of the electron transport chain (ETC) at complex I dur...
Source: Biochemical and Biophysical Research communications - April 9, 2023 Category: Biochemistry Authors: Zehui Li Hao Wang Linda Ines Zoungrana Adewale James Lily Slotabec Steven Didik Mohammad Kasim Fatmi Meredith Krause-Hauch Edward J Lesnefsky Ji Li Source Type: research
Metformin reverses oxidative stress ‑induced mitochondrial dysfunction in pre‑osteoblasts via the EGFR/GSK‑3β/calcium pathway
Int J Mol Med. 2023 Apr;51(4):36. doi: 10.3892/ijmm.2023.5239. Epub 2023 Mar 31.ABSTRACTOxidative stress is one of the main causes of osteoblast apoptosis induced by post‑menopausal osteoporosis. The authors previously found that metformin can reverse the loss of bone mass in post‑menopausal osteoporosis. The present study aimed to further clarify the effects and mechanisms of action of metformin in post‑menopausal osteoporosis under conditions of oxidative stress. Combined with an in‑depth investigation using the transcriptome database, the association between oxidative stress and mitochondrial dysfunction in post...
Source: International Journal of Molecular Medicine - March 31, 2023 Category: Molecular Biology Authors: Fangming Cao Keda Yang Shui Qiu Jie Li Wen Jiang Lin Tao Yue Zhu Source Type: research
Metformin ameliorates calcium oxalate crystallization and stone formation by activating the Nrf2/HO-1 signaling pathway: Two birds with one stone
In this study we investigated the beneficial effects of metformin hydrochloride (MH) against nephrolithiasis and explored the underlying molecular mechanism. Our results demonstrated that MH inhibited the formation of CaOx crystals and promoted the transformation of thermodynamically stable CaOx monohydrate (COM) to more unstable CaOx dihydrate (COD). MH treatment effectively ameliorated oxalate-induced oxidative injury and mitochondrial damage in renal tubular cells and reduced CaOx crystal deposition in rat kidneys. MH also attenuated oxidative stress by lowering MDA level and enhancing SOD activity in HK-2 and NRK-52E c...
Source: Archives of Biochemistry and Biophysics - March 13, 2023 Category: Biochemistry Authors: Xiaofang Zhang Futu Liang Tianyang Li Yaodong Jiang Fei Ren Source Type: research
Contribution of calcium dysregulation to impaired coronary artery contraction in Zucker diabetic fatty rats
This study explored the role and mechanism of Ca2+ handling in coronary artery dysfunction in type 2 diabetic rats. Zucker diabetic fatty (ZDF) rats were used as the type 2 diabetes mellitus model. The contractility of coronary artery rings induced by KCl, CaCl2 , 5-HT and U46619 was significantly lower in ZDF rats than in Zucker lean rats. Vasoconstriction induced by 5-HT and U46619 was greatly inhibited by nifedipine. However, in the presence of 1 μM nifedipine or in the Ca2+ -free KH solution containing 1 μM nifedipine, there was no difference in the vasoconstriction between ZL and ZDF rats. Store-operated calcium cha...
Source: Clinical and Experimental Pharmacology and Physiology - October 30, 2022 Category: Drugs & Pharmacology Authors: Lin Liu Hui Yang Su-Juan Kuang Li Zhang Meng-Yuan Zhou Peng Zeng Meng-Zhen Zhang Fang Rao Zhi-Ling Zhou Chun-Yu Deng Source Type: research
