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Drug: Verapamil

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Total 38 results found since Jan 2013.

E-228 Single center experience using 3mm trevo stent retrievers in medium vessel occlusion thrombectomy
ConclusionUse of 3mm Trevo NXT stent retriever in medium vessel occlusion for first line and rescue thrombectomy in our single center experience demonstrated an adequate safety and efficacy profile, thus endorsing its use in mechanical thrombectomy applications beyond large vessel occlusion cases. Future multicenter studies will build upon this initial experience to further characterize the utility of novel stent retrievers in medium vessel occlusions.Disclosures C. Zhao: None. M. Koneru: None. J. Siegler: None. N. Vigilante: None. J. Khalife: None. D. Tonetti: None. H. Shaikh: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Zhao, C., Koneru, M., Siegler, J., Vigilante, N., Khalife, J., Tonetti, D., Shaikh, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Intra-arterial verapamil improves functional outcomes of thrombectomy in a preclinical model of extended hyperglycemic stroke
The abrupt hyperglycemic reperfusion following thrombectomy has been shown to harm the efficacy of the intervention in stroke patients with large vessel occlusion. Studies of ours and others have shown thioredoxin-interacting protein (TXNIP) is critically involved in hyperglycemic stroke injury. We recently found verapamil ameliorates cerebrovascular toxicity of tissue plasminogen activators in hyperglycemic stroke. The present study aims to answer if verapamil exerts direct neuroprotective effects and alleviates glucose toxicity following thrombectomy in a preclinical model of hyperglycemic stroke. Primary cortical neural...
Source: Frontiers in Pharmacology - April 13, 2023 Category: Drugs & Pharmacology Source Type: research

E-184 Transradial approach for pediatric diagnostic and neurointerventional surgery: single center case series and systematic review
ConclusionsOur results and the literature review demonstrate that the TRA is a safe and feasible option for pediatric patients. Routine use of ultrasound guidance, selection of appropriately sized catheters, and prophylactic use of vasodilators and antispasmodics can help ensure the success of the procedure and limit common access-site complications.Disclosures A. Baig: None. J. Neumaier: None. Y. Hashmi: None. A. Monteiro: None. M. Waqas: None. J. Cappuzzo: None. W. Khawar: None. K. Snyder: 2; C; Canon Medical Systems Corporation, Penumbra Inc., Medtronic, and Jacobs Institute. 4; C; : Boston Scientific, Access Closure In...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Baig, A., Neumaier, J., Hashmi, Y., Monteiro, A., Waqas, M., Cappuzzo, J., Khawar, W., Snyder, K., Levy, E., Siddiqui, A., Reynolds, R., Davies, J. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

O-042 Incidence of periprocedural stroke with radial access for diagnostic cerebral angiograms
ConclusionIn our experience, transradial access for diagnostic cerebral angiograms was associated with a low but not neglectable incidence of periprocedural strokes when compared to the traditional femoral approach. Patient vascular anatomy should be evaluated prior to selection of vascular access and patients should be made aware of the possibility of a slightly higher possibility of periprocedural stroke with transradial access.Abstract O-042 Table 1 Patient Age Access Vessels catheterized Catheter used Radial Medication Contrast Fluoro Time Platelet Count INR GFR COVID Status Stroke Symptoms NIHSS Imaging performed 1 5...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kuhn, A., Singh, J., de Macedo Rodrigues, K., Massari, F., Puri, A. Tags: SNIS 19th annual meeting oral abstracts Source Type: research

Endovascular Therapy for Intracranial Giant Cell Arteritis
ConclusionEndovascular treatment, including PTA with or without stenting or calcium channel blocker infusion, may be effective therapies in medically refractory GCA with intracranial stenosis.
Source: Clinical Neuroradiology - May 3, 2022 Category: Neurology Source Type: research

E-060 Endovascular treatment for intracranial giant cell arteritis with angioplasty, stenting, and intra-arterial calcium channel blockers
ConclusionsEndovascular treatment, including PTA (with or without stenting) and CCB infusion, may be effective in medically-refractory GCA with intracranial arterial stenosis but complication rates are considerable. The efficacy of CCB monotherapy implicates vascular smooth muscle dysfunction in the pathogenesis of intracranial GCA.Calcium-channel blocker infusion as monotherapy for intracranial giant cell arteritis. Pre-treatment angiography (lateral right internal carotid artery projection) shows severe focal supraclinoid ICA stenosis (curved white arrow, 1A). Post-verapamil infusion (20mg, 15 min delay) angiogram (1B) s...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Caton, M., Mark, I., Baker, A., Narsinh, K., Halbach, V., Hetts, S., Cooke, D., Higashida, R., Dowd, C., Smith, W., Amans, M. Tags: Electronic poster abstracts Source Type: research

Association between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study
Clin Pharmacol Ther. 2021 Jul 19. doi: 10.1002/cpt.2369. Online ahead of print.ABSTRACTConcomitant use of direct oral anticoagulants (DOACs) and medications with inhibition/induction effect on P-gp/CYP3A might increase risk of bleeding/treatment failure, respectively. We designed a nested case-control study within a Clalit cohort of atrial fibrillation (AF) patients and a cohort of venous thromboembolic patients, new users of a DOAC (1.1.2010-24.8.2020). Propensity scores were constructed from demographic, clinical and medications at cohort entry. Each case of: 1) serious bleeding event; 2) stroke/systemic emboli (SE) in A...
Source: Clinical Pharmacology and Therapeutics - July 21, 2021 Category: Drugs & Pharmacology Authors: Naomi Gronich Nilli Stein Mordehcai Muszkat Source Type: research

SMART Syndrome Identification and Successful Treatment
We report a 41-year-old male patient admitted to our emergency room with a reduced level of consciousness and global aphasia. One month prior to admission, he started with frequent headache attacks of moderate intensity and paroxysmal behavioral alterations, advancing to confusion, gait instability, language impairment, and somnolence. He had a history of medulloblastoma treated with surgical resection followed by craniospinal irradiation 21 years before symptom onset. After excluding more frequent causes for the patient ’s symptoms along with a suggestive image pattern, we started treatment for SMART syndrome with high-...
Source: Case Reports in Neurology - January 25, 2021 Category: Neurology Source Type: research

Intra-arterial neuroprotective therapy as an adjunct to endovascular intervention in acute ischemic stroke: A review of the literature and future directions.
Authors: Link TW, Santillan A, Patsalides A Abstract Mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion has been shown to significantly improve outcomes. However, despite efficient rates of recanalization (60-90%), the rates of functional independence remain suboptimal (14-58%), most likely due to pathways of cell death in the brain that have already committed despite successful reperfusion. Pharmacologic neuroprotection provides a potential means of preventing this inevitable damage through targeting excitotoxicity, reactive oxygen species, cellular apoptosis, and inflammation. Numerou...
Source: Interventional Neuroradiology - May 21, 2020 Category: Radiology Tags: Interv Neuroradiol Source Type: research

The real world use of combined P-glycoprotein and moderate CYP3A4 inhibitors with rivaroxaban or apixaban increases bleeding
AbstractThe use of direct oral anticoagulants for stroke prevention in atrial fibrillation continues to rise. Certain populations may be at higher risk for increased drug exposure and adverse events. Pharmacokinetic studies suggest increased exposure of rivaroxaban and apixaban with combined P-gp and moderate CYP3A4 inhibitors but the clinical relevance of this is unknown. This retrospective cohort study included patients receiving rivaroxaban or apixaban from January 1, 2012 to December 31, 2016 with a moderate inhibitor (amiodarone, dronedarone, diltiazem, verapamil) for at least 3 months in the drug –drug interaction ...
Source: Journal of Thrombosis and Thrombolysis - January 9, 2020 Category: Hematology Source Type: research

Systolic blood pressure, heart rate, and outcomes in patients with coronary disease and heart failure
ConclusionsIn patients with CAD, a physician diagnosis of HF at baseline portended a higher risk for death, MI, or stroke than in those without an HF history. Achieving SBP of 120 –140 mmHg and heart rate< 85 b.p.m. was associated with a better outcome in patients with known HF and CAD.
Source: ESC Heart Failure - December 14, 2019 Category: Cardiology Authors: Islam Y. Elgendy, James A. Hill, Anita D. Szady, Yan Gong, Rhonda M. Cooper ‐DeHoff, Carl J. Pepine Tags: Original Research Article Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research