E-060 Endovascular treatment for intracranial giant cell arteritis with angioplasty, stenting, and intra-arterial calcium channel blockers

ConclusionsEndovascular treatment, including PTA (with or without stenting) and CCB infusion, may be effective in medically-refractory GCA with intracranial arterial stenosis but complication rates are considerable. The efficacy of CCB monotherapy implicates vascular smooth muscle dysfunction in the pathogenesis of intracranial GCA.Calcium-channel blocker infusion as monotherapy for intracranial giant cell arteritis. Pre-treatment angiography (lateral right internal carotid artery projection) shows severe focal supraclinoid ICA stenosis (curved white arrow, 1A). Post-verapamil infusion (20mg, 15 min delay) angiogram (1B) shows significant improvement in lumen diameter. Four-dimensional digital subtraction angiography (not shown) confirmed normalization of time-to-peak in the petrous ICA from 4.5s to 1.0s after verapamil infusion.Disclosures M. Caton: None. I. Mark: None. A. Baker: None. K. Narsinh: None. V. Halbach: None. S. Hetts: None. D. Cooke: None. R. Higashida: None. C. Dowd: None. W. Smith: None. M. Amans: None.

Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Caton, M., Mark, I., Baker, A., Narsinh, K., Halbach, V., Hetts, S., Cooke, D., Higashida, R., Dowd, C., Smith, W., Amans, M. Tags: Electronic poster abstracts Source Type: research