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Specialty: Molecular Biology
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Total 391 results found since Jan 2013.
New insights on the potential anti-epileptic effect of metformin: Mechanistic pathway
In conclusion, metformin might be an adjuvant with AEAs in the management of refractory epilepsy. Preclinical and clinical studies are warranted in this regard.PMID:37737447 | DOI:10.1111/jcmm.17965
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Saud A Alnaaim Hayder M Al-Kuraishy Ali I Al-Gareeb Naif H Ali Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
In conclusion, metformin combined with rapamycin decreased proteinuria, improved renal fibrosis and podocyte autophagy via AMPK/mTOR pathway in IMN rats. The metformin and rapamycin decreased proteinuria and inproved renal fibrosis in IMN model rats.PMID:37702819 | DOI:10.1007/s12079-023-00781-8
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Meichen Ma Yue Pan Yue Zhang Mei Yang Ying Xi Baoxu Lin Wudi Hao Jianhua Liu Lina Wu Yong Liu Xiaosong Qin Source Type: research
Non-coding RNA genes modulate PI3K/AKT signaling pathway in polycystic ovary syndrome
CONCLUSIONS: miRNA486 and miRNA483 downregulation may contribute to the etiology of PCOS, influence glucose metabolism, and result in IR in PCOS. Metformin's upregulation of those miRNAs affects glucose metabolism by controlling the expression of GLUT4, ameliorates PCOS-related insulin resistance, and improves PCOS-related hormonal imbalance by controlling the PI3K/AKT signaling pathway.PMID:37620736 | DOI:10.1007/s11033-023-08604-0
Source: Molecular Biology Reports - August 24, 2023 Category: Molecular Biology Authors: Heba S Omar Osama Ahmed Ibrahim Maha Gomaa Sayed Eman Mohammed Faruk Hanan Fouad Miriam Safwat Source Type: research
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia
EMBO Mol Med. 2023 Aug 23:e16908. doi: 10.15252/emmm.202216908. Online ahead of print.ABSTRACTPeriventricular neuronal heterotopia (PH) is one of the most common forms of cortical malformation in the human cortex. We show that human neuronal progenitor cells (hNPCs) derived from PH patients with a DCHS1 or FAT4 mutation as well as isogenic lines had altered migratory dynamics when grafted in the mouse brain. The affected migration was linked to altered autophagy as observed in vivo with an electron microscopic analysis of grafted hNPCs, a Western blot analysis of cortical organoids, and time-lapse imaging of hNPCs in the p...
Source: Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Cedric Bressan Marta Snapyan Marina Snapyan Johannes Klaus Francesco di Matteo Stephen P Robertson Barbara Treutlein Martin Parent Silvia Cappello Armen Saghatelyan Source Type: research
The role of immunosuppressive myofibroblasts in the aging process and age-related diseases
J Mol Med (Berl). 2023 Aug 22. doi: 10.1007/s00109-023-02360-1. Online ahead of print.ABSTRACTTissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to adapt to the changes in the microenvironment and thus maintain tissue homeostasis. Several stresses, also those associated with the aging process, convert quiescent fibroblasts into myofibroblasts which not only display fibrogenic properties but also act as immune regulators cooperating both with tissue-resident immune cells and those immune cells r...
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Antero Salminen Source Type: research
Adding empagliflozin to sitagliptin plus metformin vs. adding sitagliptin to empagliflozin plus metformin as triple therapy in Egyptian patients with type 2 diabetes: a 12-week open trial
CONCLUSIONS: Empagliflozin was superior to sitagliptin in relation to glycemic control, weight, and systolic/diastolic blood pressure reduction.PMID:37606137 | DOI:10.26355/eurrev_202308_33300
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: H G Zakaraia H F Salem M A A Mostafa A M Ali H Rabea Source Type: research
Updates on RPE cell damage in diabetic retinopathy (Review)
Mol Med Rep. 2023 Oct;28(4):185. doi: 10.3892/mmr.2023.13072. Epub 2023 Aug 18.ABSTRACTDiabetic retinopathy (DR) is a microvascular complication of diabetes. The retinal pigment epithelium (RPE) forms the outer layer of the blood‑retinal barrier and serves a role in maintaining retinal function. RPE cell injury has been revealed in diabetic animal models, and high glucose (HG) levels may cause damage to RPE cells by increasing the levels of oxidative stress, promoting pro‑inflammatory gene expression, disrupting cell proliferation, inducing the endothelial‑mesenchymal transition, weakening tight conjunctions and elev...
Source: Molecular Medicine - August 18, 2023 Category: Molecular Biology Authors: Min Li Meimei Tian Yuling Wang Huijie Ma Yaru Zhou Xinli Jiang Yan Liu Source Type: research
Pharmacological and Pathological Effects of Mulberry Leaf Extract on the Treatment of Type 1 Diabetes Mellitus Mice
This study investigated the pharmacological and pathological effects of aqueous mulberry leaf extract on type 1 diabetes mellitus mice induced with an intraperitoneal injection of streptozotocin (STZ). Diabetic mice were randomized into six groups: control (normal group), model, metformin-treated mice, and high-dose, medium-dose, and low-dose mulberry. The mulberry-treated mice were divided into high-, medium-, and low-dose groups based on the various doses of aqueous mulberry leaf extract during gavage. The efficacy of the six-week intervention was evaluated by measuring levels of fasting plasma glucose, alkaline phosphat...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Liru Luo Wei Fan Jingping Qin Shiyin Guo Hang Xiao Zhonghai Tang Source Type: research
